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Helicobacter pylori : Is it Transmitted Through Faecal-oral or Oral-oral Route?

Mulchandani, Rupa ; Nilsson, Hans-Olof LU ; Wadström, Torkel LU and Joshi, B. R. (2013) In Journal of Pure and Applied Microbiology 7(3). p.2429-2438
Abstract
The association of Helicobacter pylori with gastroduodenal diseases is well established. The mode of transmission of the organism is still unclear, although the faecal-oral route has been proposed. H. pylori has been detected in gastric antrum, dental plaques, faeces and water. In the light of these studies we attempted to detect H. pylori in antral biopsies, dental plaques, and stool specimens of patients who were suffering from upper GI complaints. These patients resided in Mumbai city, India. Clinical specimens from different sources were subjected to RUT, Culture, Histopathology and Polymerase chain reaction (PCR). We found H. pylori in antral biopsies and faeces by culture and PCR but absent in dental plaques. Therefore, faecal-oral... (More)
The association of Helicobacter pylori with gastroduodenal diseases is well established. The mode of transmission of the organism is still unclear, although the faecal-oral route has been proposed. H. pylori has been detected in gastric antrum, dental plaques, faeces and water. In the light of these studies we attempted to detect H. pylori in antral biopsies, dental plaques, and stool specimens of patients who were suffering from upper GI complaints. These patients resided in Mumbai city, India. Clinical specimens from different sources were subjected to RUT, Culture, Histopathology and Polymerase chain reaction (PCR). We found H. pylori in antral biopsies and faeces by culture and PCR but absent in dental plaques. Therefore, faecal-oral is the possible route of transmission of this bacterium. Dental plaque may not be a permanent reservoir of this bacterium because this organism needs strict microaerophilic conditions to survive. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Helicobacter pylori, PCR, faeces, HPU, VacA, CagA
in
Journal of Pure and Applied Microbiology
volume
7
issue
3
pages
2429 - 2438
publisher
DR M N KHAN
external identifiers
  • wos:000326482600117
  • scopus:84888778648
ISSN
0973-7510
language
English
LU publication?
yes
id
c3ee3c47-2270-49b2-938e-5fc0df0a634c (old id 4204088)
date added to LUP
2016-04-01 13:55:18
date last changed
2020-01-12 14:04:54
@article{c3ee3c47-2270-49b2-938e-5fc0df0a634c,
  abstract     = {The association of Helicobacter pylori with gastroduodenal diseases is well established. The mode of transmission of the organism is still unclear, although the faecal-oral route has been proposed. H. pylori has been detected in gastric antrum, dental plaques, faeces and water. In the light of these studies we attempted to detect H. pylori in antral biopsies, dental plaques, and stool specimens of patients who were suffering from upper GI complaints. These patients resided in Mumbai city, India. Clinical specimens from different sources were subjected to RUT, Culture, Histopathology and Polymerase chain reaction (PCR). We found H. pylori in antral biopsies and faeces by culture and PCR but absent in dental plaques. Therefore, faecal-oral is the possible route of transmission of this bacterium. Dental plaque may not be a permanent reservoir of this bacterium because this organism needs strict microaerophilic conditions to survive.},
  author       = {Mulchandani, Rupa and Nilsson, Hans-Olof and Wadström, Torkel and Joshi, B. R.},
  issn         = {0973-7510},
  language     = {eng},
  number       = {3},
  pages        = {2429--2438},
  publisher    = {DR M N KHAN},
  series       = {Journal of Pure and Applied Microbiology},
  title        = {Helicobacter pylori : Is it Transmitted Through Faecal-oral or Oral-oral Route?},
  volume       = {7},
  year         = {2013},
}