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Changes in alpha, theta, and gamma oscillations in distinct cortical areas are associated with altered acute pain responses in chronic low back pain patients.

Kenefati, George ; Rockholt, Mika LU orcid ; Ok, Deborah ; McCartin, Michael ; Zhang, Qiaosheng ; Sun, Guanghao ; Maslinski, Julia ; Wang, Aaron ; Chen, Baldwin and Voigt, Erich P. , et al. (2023) In Frontiers in Neuroscience 17. p.01-13
Abstract
Introduction: Chronic pain negatively impacts a range of sensory and affective behaviors. Previous studies have shown that the presence of chronic pain not only causes hypersensitivity at the site of injury but may also be associated with pain-aversive experiences at anatomically unrelated sites. While animal studies have indicated that the cingulate and prefrontal cortices are involved in this generalized hyperalgesia, the mechanisms distinguishing increased sensitivity at the site of injury from a generalized site-nonspecific enhancement in the aversive response to nociceptive inputs are not well known.

Methods: We compared measured pain responses to peripheral mechanical stimuli applied to a site of chronic pain and at a... (More)
Introduction: Chronic pain negatively impacts a range of sensory and affective behaviors. Previous studies have shown that the presence of chronic pain not only causes hypersensitivity at the site of injury but may also be associated with pain-aversive experiences at anatomically unrelated sites. While animal studies have indicated that the cingulate and prefrontal cortices are involved in this generalized hyperalgesia, the mechanisms distinguishing increased sensitivity at the site of injury from a generalized site-nonspecific enhancement in the aversive response to nociceptive inputs are not well known.

Methods: We compared measured pain responses to peripheral mechanical stimuli applied to a site of chronic pain and at a pain-free site in participants suffering from chronic lower back pain (n = 15) versus pain-free control participants (n = 15) by analyzing behavioral and electroencephalographic (EEG) data.

Results: As expected, participants with chronic pain endorsed enhanced pain with mechanical stimuli in both back and hand. We further analyzed electroencephalographic (EEG) recordings during these evoked pain episodes. Brain oscillations in theta and alpha bands in the medial orbitofrontal cortex (mOFC) were associated with localized hypersensitivity, while increased gamma oscillations in the anterior cingulate cortex (ACC) and increased theta oscillations in the dorsolateral prefrontal cortex (dlPFC) were associated with generalized hyperalgesia. (Less)
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publishing date
type
Contribution to journal
publication status
published
in
Frontiers in Neuroscience
volume
17
article number
1278183
pages
01 - 13
publisher
Frontiers Media S. A.
external identifiers
  • pmid:37901433
  • scopus:85175256161
ISSN
1662-4548
DOI
10.3389/fnins.2023.1278183
language
English
LU publication?
no
id
c3f04e8d-6906-426f-af2a-5538654a6707
date added to LUP
2024-01-08 22:15:42
date last changed
2024-01-09 08:25:23
@article{c3f04e8d-6906-426f-af2a-5538654a6707,
  abstract     = {{Introduction: Chronic pain negatively impacts a range of sensory and affective behaviors. Previous studies have shown that the presence of chronic pain not only causes hypersensitivity at the site of injury but may also be associated with pain-aversive experiences at anatomically unrelated sites. While animal studies have indicated that the cingulate and prefrontal cortices are involved in this generalized hyperalgesia, the mechanisms distinguishing increased sensitivity at the site of injury from a generalized site-nonspecific enhancement in the aversive response to nociceptive inputs are not well known.<br/><br/>Methods: We compared measured pain responses to peripheral mechanical stimuli applied to a site of chronic pain and at a pain-free site in participants suffering from chronic lower back pain (n = 15) versus pain-free control participants (n = 15) by analyzing behavioral and electroencephalographic (EEG) data.<br/><br/>Results: As expected, participants with chronic pain endorsed enhanced pain with mechanical stimuli in both back and hand. We further analyzed electroencephalographic (EEG) recordings during these evoked pain episodes. Brain oscillations in theta and alpha bands in the medial orbitofrontal cortex (mOFC) were associated with localized hypersensitivity, while increased gamma oscillations in the anterior cingulate cortex (ACC) and increased theta oscillations in the dorsolateral prefrontal cortex (dlPFC) were associated with generalized hyperalgesia.}},
  author       = {{Kenefati, George and Rockholt, Mika and Ok, Deborah and McCartin, Michael and Zhang, Qiaosheng and Sun, Guanghao and Maslinski, Julia and Wang, Aaron and Chen, Baldwin and Voigt, Erich P. and Sage Chen, Zhe and Wang, Jing and Doan, Lisa V.}},
  issn         = {{1662-4548}},
  language     = {{eng}},
  month        = {{10}},
  pages        = {{01--13}},
  publisher    = {{Frontiers Media S. A.}},
  series       = {{Frontiers in Neuroscience}},
  title        = {{Changes in alpha, theta, and gamma oscillations in distinct cortical areas are associated with altered acute pain responses in chronic low back pain patients.}},
  url          = {{http://dx.doi.org/10.3389/fnins.2023.1278183}},
  doi          = {{10.3389/fnins.2023.1278183}},
  volume       = {{17}},
  year         = {{2023}},
}