The Role of Phytonutrient Kaempferol in the Prevention of Gastrointestinal Cancers : Recent Trends and Future Perspectives
(2024) In Cancers 16(9).- Abstract
In recent years, kaempferol, a natural flavonoid present in various fruits and vegetables, has received significant attention in gastrointestinal cancer research due to its varied therapeutic effects. Kaempferol has been proven to alter several molecular mechanisms and pathways, such as the PI3/Akt, mTOR, and Erk/MAPK pathway involved in cancer progression, showing its inhibitory effects on cell proliferation, survival, angiogenesis, metastasis, and migration. Kaempferol is processed in the liver and small intestine, but limited bioavailability has been a major concern in the clinical implications of kaempferol. Nano formulations have been proven to enhance kaempferol’s efficacy in cancer prevention. The synergy of nanotechnology and... (More)
In recent years, kaempferol, a natural flavonoid present in various fruits and vegetables, has received significant attention in gastrointestinal cancer research due to its varied therapeutic effects. Kaempferol has been proven to alter several molecular mechanisms and pathways, such as the PI3/Akt, mTOR, and Erk/MAPK pathway involved in cancer progression, showing its inhibitory effects on cell proliferation, survival, angiogenesis, metastasis, and migration. Kaempferol is processed in the liver and small intestine, but limited bioavailability has been a major concern in the clinical implications of kaempferol. Nano formulations have been proven to enhance kaempferol’s efficacy in cancer prevention. The synergy of nanotechnology and kaempferol has shown promising results in in vitro studies, highlighting the importance for more in vivo research and clinical trials to determine safety and efficacy. This review aims to focus on the role of kaempferol in various types of gastrointestinal cancer and how the combination of kaempferol with nanotechnology helps in improving therapeutic efficacy in cancer treatment.
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- author
- Singh, Tejveer ; Sharma, Deepika ; Sharma, Rishabh ; Tuli, Hardeep Singh ; Haque, Shafiul ; Ramniwas, Seema ; Mathkor, Darin Mansor and Yadav, Vikas LU
- organization
- publishing date
- 2024-05
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- apoptosis, cell cycle arrest, colorectal cancer, esophageal cancer, gastric cancer, gastrointestinal cancer, kaempferol, liver cancer, nanotechnology, pancreatic cancer
- in
- Cancers
- volume
- 16
- issue
- 9
- article number
- 1711
- publisher
- MDPI AG
- external identifiers
-
- scopus:85192753053
- pmid:38730663
- ISSN
- 2072-6694
- DOI
- 10.3390/cancers16091711
- language
- English
- LU publication?
- yes
- id
- c4117fc3-2efe-4aae-9b99-51b97418f135
- date added to LUP
- 2024-05-30 14:48:08
- date last changed
- 2024-06-13 15:42:56
@article{c4117fc3-2efe-4aae-9b99-51b97418f135,
abstract = {{<p>In recent years, kaempferol, a natural flavonoid present in various fruits and vegetables, has received significant attention in gastrointestinal cancer research due to its varied therapeutic effects. Kaempferol has been proven to alter several molecular mechanisms and pathways, such as the PI3/Akt, mTOR, and Erk/MAPK pathway involved in cancer progression, showing its inhibitory effects on cell proliferation, survival, angiogenesis, metastasis, and migration. Kaempferol is processed in the liver and small intestine, but limited bioavailability has been a major concern in the clinical implications of kaempferol. Nano formulations have been proven to enhance kaempferol’s efficacy in cancer prevention. The synergy of nanotechnology and kaempferol has shown promising results in in vitro studies, highlighting the importance for more in vivo research and clinical trials to determine safety and efficacy. This review aims to focus on the role of kaempferol in various types of gastrointestinal cancer and how the combination of kaempferol with nanotechnology helps in improving therapeutic efficacy in cancer treatment.</p>}},
author = {{Singh, Tejveer and Sharma, Deepika and Sharma, Rishabh and Tuli, Hardeep Singh and Haque, Shafiul and Ramniwas, Seema and Mathkor, Darin Mansor and Yadav, Vikas}},
issn = {{2072-6694}},
keywords = {{apoptosis; cell cycle arrest; colorectal cancer; esophageal cancer; gastric cancer; gastrointestinal cancer; kaempferol; liver cancer; nanotechnology; pancreatic cancer}},
language = {{eng}},
number = {{9}},
publisher = {{MDPI AG}},
series = {{Cancers}},
title = {{The Role of Phytonutrient Kaempferol in the Prevention of Gastrointestinal Cancers : Recent Trends and Future Perspectives}},
url = {{http://dx.doi.org/10.3390/cancers16091711}},
doi = {{10.3390/cancers16091711}},
volume = {{16}},
year = {{2024}},
}