Disease-specific hospitalizations among 5-year survivors of Wilms tumor : A Nordic population-based cohort study
(2021) In Pediatric Blood and Cancer 68(5).- Abstract
Background: With modern therapy, over 90% of Wilms tumor patients can expect to become long-term survivors, and focus on morbidity and late effects become increasingly important. We provide a novel evaluation and insight to subsequent hospitalizations in 5-year survivors of Wilms tumor. Methods: As part of the Adult Life after Childhood Cancer in Scandinavia (ALiCCS) study, we identified 5-year survivors of Wilms tumor. Based on stratified random sampling, we constructed a population comparison cohort. Outcomes of interest were overall hospitalizations; hospitalizations for specific organ systems and disease-specific categories. Standardized hospitalization rate ratios (SHRR) and absolute excess risks (AER) were calculated. Results: We... (More)
Background: With modern therapy, over 90% of Wilms tumor patients can expect to become long-term survivors, and focus on morbidity and late effects become increasingly important. We provide a novel evaluation and insight to subsequent hospitalizations in 5-year survivors of Wilms tumor. Methods: As part of the Adult Life after Childhood Cancer in Scandinavia (ALiCCS) study, we identified 5-year survivors of Wilms tumor. Based on stratified random sampling, we constructed a population comparison cohort. Outcomes of interest were overall hospitalizations; hospitalizations for specific organ systems and disease-specific categories. Standardized hospitalization rate ratios (SHRR) and absolute excess risks (AER) were calculated. Results: We included 913, 5-year survivors of Wilms tumor and 152 231 population comparisons. Survivors of Wilms tumor had an increased overall risk of being hospitalized (SHRR 1.8; 95% confidence interval (CI) 1.7-2.0). The hospitalization risk was increased within all major organ systems: urinary and genital organs (SHRR 2.5; 95% CI 2.1-3.0), endocrine (SHRR 2.5; 95% CI 1.9-3.3), cardiovascular (SHRR 2.2; 95% CI 1.7-2.9), and gastrointestinal (SHRR 1.5; 95% CI 1.3-1.8). Risks for specific diseases are reported in the study. Conclusions: Survivors of Wilms tumor had higher risks than population comparisons for a wide range of diseases, with the highest risks seen for urinary, endocrine, and cardiovascular disorders. Five to 20 years after the Wilms tumor diagnosis, 43% of survivors had been hospitalized at least once versus 29% of population comparisons. The overall AER was 2.3, which translates into 0.2 extra hospitalizations in 10 years for every Wilms tumor survivor.
(Less)
- author
- organization
- publishing date
- 2021-01-23
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- hospitalization, late effects, morbidity, survivorship, Wilms tumor
- in
- Pediatric Blood and Cancer
- volume
- 68
- issue
- 5
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- pmid:33484071
- scopus:85099771574
- ISSN
- 1545-5009
- DOI
- 10.1002/pbc.28905
- language
- English
- LU publication?
- yes
- id
- c4378e89-c41c-4305-9a8f-e4715e224ea1
- date added to LUP
- 2021-02-04 10:10:10
- date last changed
- 2024-04-18 02:01:14
@article{c4378e89-c41c-4305-9a8f-e4715e224ea1,
abstract = {{<p>Background: With modern therapy, over 90% of Wilms tumor patients can expect to become long-term survivors, and focus on morbidity and late effects become increasingly important. We provide a novel evaluation and insight to subsequent hospitalizations in 5-year survivors of Wilms tumor. Methods: As part of the Adult Life after Childhood Cancer in Scandinavia (ALiCCS) study, we identified 5-year survivors of Wilms tumor. Based on stratified random sampling, we constructed a population comparison cohort. Outcomes of interest were overall hospitalizations; hospitalizations for specific organ systems and disease-specific categories. Standardized hospitalization rate ratios (SHRR) and absolute excess risks (AER) were calculated. Results: We included 913, 5-year survivors of Wilms tumor and 152 231 population comparisons. Survivors of Wilms tumor had an increased overall risk of being hospitalized (SHRR 1.8; 95% confidence interval (CI) 1.7-2.0). The hospitalization risk was increased within all major organ systems: urinary and genital organs (SHRR 2.5; 95% CI 2.1-3.0), endocrine (SHRR 2.5; 95% CI 1.9-3.3), cardiovascular (SHRR 2.2; 95% CI 1.7-2.9), and gastrointestinal (SHRR 1.5; 95% CI 1.3-1.8). Risks for specific diseases are reported in the study. Conclusions: Survivors of Wilms tumor had higher risks than population comparisons for a wide range of diseases, with the highest risks seen for urinary, endocrine, and cardiovascular disorders. Five to 20 years after the Wilms tumor diagnosis, 43% of survivors had been hospitalized at least once versus 29% of population comparisons. The overall AER was 2.3, which translates into 0.2 extra hospitalizations in 10 years for every Wilms tumor survivor.</p>}},
author = {{Høgsholt, Stine and Asdahl, Peter Haubjerg and Bonnesen, Trine Gade and Holmqvist, Anna Sällfors and Madanat-Harjuoja, Laura and Tryggvadottir, Laufey and Bautz, Andrea and Albieri, Vanna and Green, Daniel and Winther, Jeanette Falck and Hasle, Henrik}},
issn = {{1545-5009}},
keywords = {{hospitalization; late effects; morbidity; survivorship; Wilms tumor}},
language = {{eng}},
month = {{01}},
number = {{5}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Pediatric Blood and Cancer}},
title = {{Disease-specific hospitalizations among 5-year survivors of Wilms tumor : A Nordic population-based cohort study}},
url = {{http://dx.doi.org/10.1002/pbc.28905}},
doi = {{10.1002/pbc.28905}},
volume = {{68}},
year = {{2021}},
}