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Microfluidic Platform for the Continuous Production and Characterization of Multilamellar Vesicles : A Synchrotron Small-Angle X-ray Scattering (SAXS) Study

Ghazal, Aghiad; Gontsarik, Mark; Kutter, Jörg P.; Lafleur, Josiane P.; Ahmadvand, Davoud; Labrador, Ana LU ; Salentinig, Stefan and Yaghmur, Anan (2017) In Journal of Physical Chemistry Letters 8(1). p.73-79
Abstract

A microfluidic platform combined with synchrotron small-angle X-ray scattering (SAXS) was used for monitoring the continuous production of multilamellar vesicles (MLVs). Their production was fast and started to evolve within less than 0.43 s of contact between the lipids and the aqueous phase. To obtain nanoparticles with a narrow size distribution, it was important to use a modified hydrodynamic flow focusing (HFF) microfluidic device with narrower microchannels than those normally used for SAXS experiments. Monodispersed MLVs as small as 160 nm in size, with a polydispersity index (PDI) of approximately 0.15 were achieved. The nanoparticles produced were smaller and had a narrower size distribution than those obtained via conventional... (More)

A microfluidic platform combined with synchrotron small-angle X-ray scattering (SAXS) was used for monitoring the continuous production of multilamellar vesicles (MLVs). Their production was fast and started to evolve within less than 0.43 s of contact between the lipids and the aqueous phase. To obtain nanoparticles with a narrow size distribution, it was important to use a modified hydrodynamic flow focusing (HFF) microfluidic device with narrower microchannels than those normally used for SAXS experiments. Monodispersed MLVs as small as 160 nm in size, with a polydispersity index (PDI) of approximately 0.15 were achieved. The nanoparticles produced were smaller and had a narrower size distribution than those obtained via conventional bulk mixing methods. This microfluidic platform therefore has a great potential for the continuous production of monodispersed NPs.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Physical Chemistry Letters
volume
8
issue
1
pages
7 pages
publisher
The American Chemical Society
external identifiers
  • scopus:85018521726
  • wos:000391653200013
ISSN
1948-7185
DOI
10.1021/acs.jpclett.6b02468
language
English
LU publication?
yes
id
c44624b8-491f-4672-a830-e167d1e9e79e
date added to LUP
2017-05-22 11:26:52
date last changed
2018-01-07 12:04:41
@article{c44624b8-491f-4672-a830-e167d1e9e79e,
  abstract     = {<p>A microfluidic platform combined with synchrotron small-angle X-ray scattering (SAXS) was used for monitoring the continuous production of multilamellar vesicles (MLVs). Their production was fast and started to evolve within less than 0.43 s of contact between the lipids and the aqueous phase. To obtain nanoparticles with a narrow size distribution, it was important to use a modified hydrodynamic flow focusing (HFF) microfluidic device with narrower microchannels than those normally used for SAXS experiments. Monodispersed MLVs as small as 160 nm in size, with a polydispersity index (PDI) of approximately 0.15 were achieved. The nanoparticles produced were smaller and had a narrower size distribution than those obtained via conventional bulk mixing methods. This microfluidic platform therefore has a great potential for the continuous production of monodispersed NPs.</p>},
  author       = {Ghazal, Aghiad and Gontsarik, Mark and Kutter, Jörg P. and Lafleur, Josiane P. and Ahmadvand, Davoud and Labrador, Ana and Salentinig, Stefan and Yaghmur, Anan},
  issn         = {1948-7185},
  language     = {eng},
  month        = {01},
  number       = {1},
  pages        = {73--79},
  publisher    = {The American Chemical Society},
  series       = {Journal of Physical Chemistry Letters},
  title        = {Microfluidic Platform for the Continuous Production and Characterization of Multilamellar Vesicles : A Synchrotron Small-Angle X-ray Scattering (SAXS) Study},
  url          = {http://dx.doi.org/10.1021/acs.jpclett.6b02468},
  volume       = {8},
  year         = {2017},
}