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Microfluidic Platform for the Continuous Production and Characterization of Multilamellar Vesicles : A Synchrotron Small-Angle X-ray Scattering (SAXS) Study

Ghazal, Aghiad ; Gontsarik, Mark ; Kutter, Jörg P. ; Lafleur, Josiane P. ; Ahmadvand, Davoud ; Labrador, Ana LU orcid ; Salentinig, Stefan and Yaghmur, Anan (2017) In Journal of Physical Chemistry Letters 8(1). p.73-79
Abstract

A microfluidic platform combined with synchrotron small-angle X-ray scattering (SAXS) was used for monitoring the continuous production of multilamellar vesicles (MLVs). Their production was fast and started to evolve within less than 0.43 s of contact between the lipids and the aqueous phase. To obtain nanoparticles with a narrow size distribution, it was important to use a modified hydrodynamic flow focusing (HFF) microfluidic device with narrower microchannels than those normally used for SAXS experiments. Monodispersed MLVs as small as 160 nm in size, with a polydispersity index (PDI) of approximately 0.15 were achieved. The nanoparticles produced were smaller and had a narrower size distribution than those obtained via conventional... (More)

A microfluidic platform combined with synchrotron small-angle X-ray scattering (SAXS) was used for monitoring the continuous production of multilamellar vesicles (MLVs). Their production was fast and started to evolve within less than 0.43 s of contact between the lipids and the aqueous phase. To obtain nanoparticles with a narrow size distribution, it was important to use a modified hydrodynamic flow focusing (HFF) microfluidic device with narrower microchannels than those normally used for SAXS experiments. Monodispersed MLVs as small as 160 nm in size, with a polydispersity index (PDI) of approximately 0.15 were achieved. The nanoparticles produced were smaller and had a narrower size distribution than those obtained via conventional bulk mixing methods. This microfluidic platform therefore has a great potential for the continuous production of monodispersed NPs.

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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Physical Chemistry Letters
volume
8
issue
1
pages
7 pages
publisher
The American Chemical Society (ACS)
external identifiers
  • pmid:27936765
  • wos:000391653200013
  • scopus:85018521726
ISSN
1948-7185
DOI
10.1021/acs.jpclett.6b02468
language
English
LU publication?
yes
id
c44624b8-491f-4672-a830-e167d1e9e79e
date added to LUP
2017-05-22 11:26:52
date last changed
2025-01-07 13:55:50
@article{c44624b8-491f-4672-a830-e167d1e9e79e,
  abstract     = {{<p>A microfluidic platform combined with synchrotron small-angle X-ray scattering (SAXS) was used for monitoring the continuous production of multilamellar vesicles (MLVs). Their production was fast and started to evolve within less than 0.43 s of contact between the lipids and the aqueous phase. To obtain nanoparticles with a narrow size distribution, it was important to use a modified hydrodynamic flow focusing (HFF) microfluidic device with narrower microchannels than those normally used for SAXS experiments. Monodispersed MLVs as small as 160 nm in size, with a polydispersity index (PDI) of approximately 0.15 were achieved. The nanoparticles produced were smaller and had a narrower size distribution than those obtained via conventional bulk mixing methods. This microfluidic platform therefore has a great potential for the continuous production of monodispersed NPs.</p>}},
  author       = {{Ghazal, Aghiad and Gontsarik, Mark and Kutter, Jörg P. and Lafleur, Josiane P. and Ahmadvand, Davoud and Labrador, Ana and Salentinig, Stefan and Yaghmur, Anan}},
  issn         = {{1948-7185}},
  language     = {{eng}},
  month        = {{01}},
  number       = {{1}},
  pages        = {{73--79}},
  publisher    = {{The American Chemical Society (ACS)}},
  series       = {{Journal of Physical Chemistry Letters}},
  title        = {{Microfluidic Platform for the Continuous Production and Characterization of Multilamellar Vesicles : A Synchrotron Small-Angle X-ray Scattering (SAXS) Study}},
  url          = {{http://dx.doi.org/10.1021/acs.jpclett.6b02468}},
  doi          = {{10.1021/acs.jpclett.6b02468}},
  volume       = {{8}},
  year         = {{2017}},
}