The impact of lymph vascular space invasion on recurrence and survival in patients with early stage endometrial cancer
(2014) In European Journal of Cancer Care 23(3). p.380-384- Abstract
The aim of this study was to determine impact of lymph vascular space involvement (LVSI) on recurrence and survival in early stage of endometrial cancer. From 1991 through 2010, all endometrial cancer patients at University Hospital of Bari, Italy were identified. The Log-rank test and Kaplan-Meyer methods were used for time-to-event analysis to evaluate the effects of on lymph vascular space involvement recurrence rate and survival time. Of the 560 endometrial cancer patients, 525 underwent primary surgery. Of those, 399 had early stage disease. Three hundred and forty women were not found to have LVSI, whereas 59 were found to have lymph vascular space involvement. Forty-nine (12%) patients developed a recurrence and 20 of them showed... (More)
The aim of this study was to determine impact of lymph vascular space involvement (LVSI) on recurrence and survival in early stage of endometrial cancer. From 1991 through 2010, all endometrial cancer patients at University Hospital of Bari, Italy were identified. The Log-rank test and Kaplan-Meyer methods were used for time-to-event analysis to evaluate the effects of on lymph vascular space involvement recurrence rate and survival time. Of the 560 endometrial cancer patients, 525 underwent primary surgery. Of those, 399 had early stage disease. Three hundred and forty women were not found to have LVSI, whereas 59 were found to have lymph vascular space involvement. Forty-nine (12%) patients developed a recurrence and 20 of them showed lymph vascular space involvement. The statistical analysis demonstrated that LVSI was strongly associated with a poor survival (P < 0.0001). Lymph vascular space involvement is associated with a high risk of recurrence and poor overall survival in early stage of endometrial cancer; therefore, the clinical decision to decide whether or not a patient with early stage endometrial cancer should receive adjuvant therapy should be included the evaluation of lymph vascular space involvement.
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- author
- Loizzi, V. ; Cormio, G. ; Lorusso, M. ; Latorre, D. ; Falagario, M. LU ; Demitri, P. ; Scardigno, D. and Selvaggi, L. E.
- publishing date
- 2014-01-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Early stage endometrial cancer, Lymph vascular space invasion, Prognostic factors endometrial cancer
- in
- European Journal of Cancer Care
- volume
- 23
- issue
- 3
- pages
- 5 pages
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- pmid:24112088
- scopus:84899494335
- ISSN
- 0961-5423
- DOI
- 10.1111/ecc.12115
- language
- English
- LU publication?
- no
- id
- c4537898-c7d1-4543-ad4b-1df54394f4da
- date added to LUP
- 2019-02-16 08:32:29
- date last changed
- 2024-08-20 10:43:43
@article{c4537898-c7d1-4543-ad4b-1df54394f4da, abstract = {{<p>The aim of this study was to determine impact of lymph vascular space involvement (LVSI) on recurrence and survival in early stage of endometrial cancer. From 1991 through 2010, all endometrial cancer patients at University Hospital of Bari, Italy were identified. The Log-rank test and Kaplan-Meyer methods were used for time-to-event analysis to evaluate the effects of on lymph vascular space involvement recurrence rate and survival time. Of the 560 endometrial cancer patients, 525 underwent primary surgery. Of those, 399 had early stage disease. Three hundred and forty women were not found to have LVSI, whereas 59 were found to have lymph vascular space involvement. Forty-nine (12%) patients developed a recurrence and 20 of them showed lymph vascular space involvement. The statistical analysis demonstrated that LVSI was strongly associated with a poor survival (P < 0.0001). Lymph vascular space involvement is associated with a high risk of recurrence and poor overall survival in early stage of endometrial cancer; therefore, the clinical decision to decide whether or not a patient with early stage endometrial cancer should receive adjuvant therapy should be included the evaluation of lymph vascular space involvement.</p>}}, author = {{Loizzi, V. and Cormio, G. and Lorusso, M. and Latorre, D. and Falagario, M. and Demitri, P. and Scardigno, D. and Selvaggi, L. E.}}, issn = {{0961-5423}}, keywords = {{Early stage endometrial cancer; Lymph vascular space invasion; Prognostic factors endometrial cancer}}, language = {{eng}}, month = {{01}}, number = {{3}}, pages = {{380--384}}, publisher = {{John Wiley & Sons Inc.}}, series = {{European Journal of Cancer Care}}, title = {{The impact of lymph vascular space invasion on recurrence and survival in patients with early stage endometrial cancer}}, url = {{http://dx.doi.org/10.1111/ecc.12115}}, doi = {{10.1111/ecc.12115}}, volume = {{23}}, year = {{2014}}, }