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The impact of lymph vascular space invasion on recurrence and survival in patients with early stage endometrial cancer

Loizzi, V. ; Cormio, G. ; Lorusso, M. ; Latorre, D. ; Falagario, M. LU orcid ; Demitri, P. ; Scardigno, D. and Selvaggi, L. E. (2014) In European Journal of Cancer Care 23(3). p.380-384
Abstract

The aim of this study was to determine impact of lymph vascular space involvement (LVSI) on recurrence and survival in early stage of endometrial cancer. From 1991 through 2010, all endometrial cancer patients at University Hospital of Bari, Italy were identified. The Log-rank test and Kaplan-Meyer methods were used for time-to-event analysis to evaluate the effects of on lymph vascular space involvement recurrence rate and survival time. Of the 560 endometrial cancer patients, 525 underwent primary surgery. Of those, 399 had early stage disease. Three hundred and forty women were not found to have LVSI, whereas 59 were found to have lymph vascular space involvement. Forty-nine (12%) patients developed a recurrence and 20 of them showed... (More)

The aim of this study was to determine impact of lymph vascular space involvement (LVSI) on recurrence and survival in early stage of endometrial cancer. From 1991 through 2010, all endometrial cancer patients at University Hospital of Bari, Italy were identified. The Log-rank test and Kaplan-Meyer methods were used for time-to-event analysis to evaluate the effects of on lymph vascular space involvement recurrence rate and survival time. Of the 560 endometrial cancer patients, 525 underwent primary surgery. Of those, 399 had early stage disease. Three hundred and forty women were not found to have LVSI, whereas 59 were found to have lymph vascular space involvement. Forty-nine (12%) patients developed a recurrence and 20 of them showed lymph vascular space involvement. The statistical analysis demonstrated that LVSI was strongly associated with a poor survival (P < 0.0001). Lymph vascular space involvement is associated with a high risk of recurrence and poor overall survival in early stage of endometrial cancer; therefore, the clinical decision to decide whether or not a patient with early stage endometrial cancer should receive adjuvant therapy should be included the evaluation of lymph vascular space involvement.

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author
; ; ; ; ; ; and
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Early stage endometrial cancer, Lymph vascular space invasion, Prognostic factors endometrial cancer
in
European Journal of Cancer Care
volume
23
issue
3
pages
5 pages
publisher
John Wiley & Sons Inc.
external identifiers
  • scopus:84899494335
  • pmid:24112088
ISSN
0961-5423
DOI
10.1111/ecc.12115
language
English
LU publication?
no
id
c4537898-c7d1-4543-ad4b-1df54394f4da
date added to LUP
2019-02-16 08:32:29
date last changed
2024-07-10 09:17:30
@article{c4537898-c7d1-4543-ad4b-1df54394f4da,
  abstract     = {{<p>The aim of this study was to determine impact of lymph vascular space involvement (LVSI) on recurrence and survival in early stage of endometrial cancer. From 1991 through 2010, all endometrial cancer patients at University Hospital of Bari, Italy were identified. The Log-rank test and Kaplan-Meyer methods were used for time-to-event analysis to evaluate the effects of on lymph vascular space involvement recurrence rate and survival time. Of the 560 endometrial cancer patients, 525 underwent primary surgery. Of those, 399 had early stage disease. Three hundred and forty women were not found to have LVSI, whereas 59 were found to have lymph vascular space involvement. Forty-nine (12%) patients developed a recurrence and 20 of them showed lymph vascular space involvement. The statistical analysis demonstrated that LVSI was strongly associated with a poor survival (P &lt; 0.0001). Lymph vascular space involvement is associated with a high risk of recurrence and poor overall survival in early stage of endometrial cancer; therefore, the clinical decision to decide whether or not a patient with early stage endometrial cancer should receive adjuvant therapy should be included the evaluation of lymph vascular space involvement.</p>}},
  author       = {{Loizzi, V. and Cormio, G. and Lorusso, M. and Latorre, D. and Falagario, M. and Demitri, P. and Scardigno, D. and Selvaggi, L. E.}},
  issn         = {{0961-5423}},
  keywords     = {{Early stage endometrial cancer; Lymph vascular space invasion; Prognostic factors endometrial cancer}},
  language     = {{eng}},
  month        = {{01}},
  number       = {{3}},
  pages        = {{380--384}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{European Journal of Cancer Care}},
  title        = {{The impact of lymph vascular space invasion on recurrence and survival in patients with early stage endometrial cancer}},
  url          = {{http://dx.doi.org/10.1111/ecc.12115}},
  doi          = {{10.1111/ecc.12115}},
  volume       = {{23}},
  year         = {{2014}},
}