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Combined diffusion-relaxometry microstructure imaging : Current status and future prospects

Slator, Paddy J. ; Palombo, Marco ; Miller, Karla L. ; Westin, Carl Fredrik ; Laun, Frederik ; Kim, Daeun ; Haldar, Justin P. ; Benjamini, Dan ; Lemberskiy, Gregory and de Almeida Martins, Joao P. LU , et al. (2021) In Magnetic Resonance in Medicine 86(6). p.2987-3011
Abstract

Microstructure imaging seeks to noninvasively measure and map microscopic tissue features by pairing mathematical modeling with tailored MRI protocols. This article reviews an emerging paradigm that has the potential to provide a more detailed assessment of tissue microstructure—combined diffusion-relaxometry imaging. Combined diffusion-relaxometry acquisitions vary multiple MR contrast encodings—such as b-value, gradient direction, inversion time, and echo time—in a multidimensional acquisition space. When paired with suitable analysis techniques, this enables quantification of correlations and coupling between multiple MR parameters—such as diffusivity, (Formula presented.), (Formula presented.), and (Formula presented.). This opens... (More)

Microstructure imaging seeks to noninvasively measure and map microscopic tissue features by pairing mathematical modeling with tailored MRI protocols. This article reviews an emerging paradigm that has the potential to provide a more detailed assessment of tissue microstructure—combined diffusion-relaxometry imaging. Combined diffusion-relaxometry acquisitions vary multiple MR contrast encodings—such as b-value, gradient direction, inversion time, and echo time—in a multidimensional acquisition space. When paired with suitable analysis techniques, this enables quantification of correlations and coupling between multiple MR parameters—such as diffusivity, (Formula presented.), (Formula presented.), and (Formula presented.). This opens the possibility of disentangling multiple tissue compartments (within voxels) that are indistinguishable with single-contrast scans, enabling a new generation of microstructural maps with improved biological sensitivity and specificity.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
diffusion, multidimensional MRI, quantitative MRI, relaxometry
in
Magnetic Resonance in Medicine
volume
86
issue
6
pages
25 pages
publisher
John Wiley & Sons Inc.
external identifiers
  • scopus:85112849426
  • pmid:34411331
ISSN
0740-3194
DOI
10.1002/mrm.28963
language
English
LU publication?
yes
id
c454a7ad-af45-4dff-9b26-943cda5ab9be
date added to LUP
2021-12-09 15:43:44
date last changed
2024-06-17 01:04:33
@article{c454a7ad-af45-4dff-9b26-943cda5ab9be,
  abstract     = {{<p>Microstructure imaging seeks to noninvasively measure and map microscopic tissue features by pairing mathematical modeling with tailored MRI protocols. This article reviews an emerging paradigm that has the potential to provide a more detailed assessment of tissue microstructure—combined diffusion-relaxometry imaging. Combined diffusion-relaxometry acquisitions vary multiple MR contrast encodings—such as b-value, gradient direction, inversion time, and echo time—in a multidimensional acquisition space. When paired with suitable analysis techniques, this enables quantification of correlations and coupling between multiple MR parameters—such as diffusivity, (Formula presented.), (Formula presented.), and (Formula presented.). This opens the possibility of disentangling multiple tissue compartments (within voxels) that are indistinguishable with single-contrast scans, enabling a new generation of microstructural maps with improved biological sensitivity and specificity.</p>}},
  author       = {{Slator, Paddy J. and Palombo, Marco and Miller, Karla L. and Westin, Carl Fredrik and Laun, Frederik and Kim, Daeun and Haldar, Justin P. and Benjamini, Dan and Lemberskiy, Gregory and de Almeida Martins, Joao P. and Hutter, Jana}},
  issn         = {{0740-3194}},
  keywords     = {{diffusion; multidimensional MRI; quantitative MRI; relaxometry}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{2987--3011}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{Magnetic Resonance in Medicine}},
  title        = {{Combined diffusion-relaxometry microstructure imaging : Current status and future prospects}},
  url          = {{http://dx.doi.org/10.1002/mrm.28963}},
  doi          = {{10.1002/mrm.28963}},
  volume       = {{86}},
  year         = {{2021}},
}