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Does depth of anesthesia influence postoperative cognitive dysfunction or inflammatory response following major ent surgery?

Jildenstål, Pether K. LU ; Hallén, Jan L. ; Rawal, Narinder and Berggren, Lars LU (2012) In Journal of Anesthesia and Clinical Research 3(6).
Abstract

The aim of this study was to evaluate the role of depth of anesthesia on POCD after major ENT surgery and to assess changes in postoperative inflammatory markers in patients undergoing major ENT surgery. Thirty two patients aged 40 to 94 yrs, scheduled for surgery under general anesthesia were randomly assigned to one of two groups. In group A (AEP group) depth of anesthesia (DOA) was measured with auditory evoked potential (AEP). In the control group (group C) DOA was monitored according to clinical signs. Cognitive function was evaluated using Mini-Mental State Examination (MMSE), Confusion Assessment Method (CAM) and Cognitive Failure Questionnaire (CFQ). Inflammatory markers were measured before and after anesthesia. Perioperative... (More)

The aim of this study was to evaluate the role of depth of anesthesia on POCD after major ENT surgery and to assess changes in postoperative inflammatory markers in patients undergoing major ENT surgery. Thirty two patients aged 40 to 94 yrs, scheduled for surgery under general anesthesia were randomly assigned to one of two groups. In group A (AEP group) depth of anesthesia (DOA) was measured with auditory evoked potential (AEP). In the control group (group C) DOA was monitored according to clinical signs. Cognitive function was evaluated using Mini-Mental State Examination (MMSE), Confusion Assessment Method (CAM) and Cognitive Failure Questionnaire (CFQ). Inflammatory markers were measured before and after anesthesia. Perioperative requirements for desflurane and fentanyl were significantly lower in group A. On the first postoperative day MMSE changes indicating POCD were noted in 1 patient in group A and 7 patients in group C (P<0.03). One month follow up did not show any difference between the groups regarding POCD. Our study indicates that AEP-guided anesthesia allows dose reduction of anesthetic agents including opioids leading to better cardiovascular stability and less early POCD. Anesthesia depth did not influence the inflammatory response to surgery.

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author
; ; and
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Auditory Evoked Potential (AEP), Cognitive decline, General anesthesia
in
Journal of Anesthesia and Clinical Research
volume
3
issue
6
article number
220
publisher
OMICS Publishing Group
external identifiers
  • scopus:84880002452
ISSN
2155-6148
DOI
10.4172/2155-6148.1000220
language
English
LU publication?
no
id
c47448e6-f943-4ba3-81ef-f40a5c7720c6
date added to LUP
2020-09-27 20:51:20
date last changed
2022-03-03 18:35:36
@article{c47448e6-f943-4ba3-81ef-f40a5c7720c6,
  abstract     = {{<p>The aim of this study was to evaluate the role of depth of anesthesia on POCD after major ENT surgery and to assess changes in postoperative inflammatory markers in patients undergoing major ENT surgery. Thirty two patients aged 40 to 94 yrs, scheduled for surgery under general anesthesia were randomly assigned to one of two groups. In group A (AEP group) depth of anesthesia (DOA) was measured with auditory evoked potential (AEP). In the control group (group C) DOA was monitored according to clinical signs. Cognitive function was evaluated using Mini-Mental State Examination (MMSE), Confusion Assessment Method (CAM) and Cognitive Failure Questionnaire (CFQ). Inflammatory markers were measured before and after anesthesia. Perioperative requirements for desflurane and fentanyl were significantly lower in group A. On the first postoperative day MMSE changes indicating POCD were noted in 1 patient in group A and 7 patients in group C (P&lt;0.03). One month follow up did not show any difference between the groups regarding POCD. Our study indicates that AEP-guided anesthesia allows dose reduction of anesthetic agents including opioids leading to better cardiovascular stability and less early POCD. Anesthesia depth did not influence the inflammatory response to surgery.</p>}},
  author       = {{Jildenstål, Pether K. and Hallén, Jan L. and Rawal, Narinder and Berggren, Lars}},
  issn         = {{2155-6148}},
  keywords     = {{Auditory Evoked Potential (AEP); Cognitive decline; General anesthesia}},
  language     = {{eng}},
  month        = {{06}},
  number       = {{6}},
  publisher    = {{OMICS Publishing Group}},
  series       = {{Journal of Anesthesia and Clinical Research}},
  title        = {{Does depth of anesthesia influence postoperative cognitive dysfunction or inflammatory response following major ent surgery?}},
  url          = {{http://dx.doi.org/10.4172/2155-6148.1000220}},
  doi          = {{10.4172/2155-6148.1000220}},
  volume       = {{3}},
  year         = {{2012}},
}