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Hyperthyroidism as a late effect in childhood cancer survivors - an Adult Life after Childhood Cancer in Scandinavia (ALiCCS) study

Clausen, Camilla T.; Hasle, Henrik; Holmqvist, Anna S. LU ; Madanat-Harjuoja, Laura; Tryggvadottir, Laufey; Wesenberg, Finn; Bautz, Andrea; Winther, Jeanette F. and Licht, Sofie de Fine (2019) In Acta Oncologica 58(2). p.227-231
Abstract

Background: Hyperthyroidism is a rare disorder which may negatively affect health and quality of life. Its occurrence in childhood cancer survivors has not previously been investigated in detail. Material and methods: In the hospital registers of the five Nordic countries, 32,944 childhood cancer survivors and 212,675 population comparisons were followed for the diagnosis of hyperthyroidism. Hospitalisation rates, standardised hospitalisation rate ratios and absolute excess risks were calculated with 95% confidence intervals (CI). Results: Hyperthyroidism was diagnosed in 131 childhood cancer survivors, yielding an overall relative risk of 1.6 (95% CI: 1.3–1.9) compared with population comparisons. The risk was greatest 1–5 years after... (More)

Background: Hyperthyroidism is a rare disorder which may negatively affect health and quality of life. Its occurrence in childhood cancer survivors has not previously been investigated in detail. Material and methods: In the hospital registers of the five Nordic countries, 32,944 childhood cancer survivors and 212,675 population comparisons were followed for the diagnosis of hyperthyroidism. Hospitalisation rates, standardised hospitalisation rate ratios and absolute excess risks were calculated with 95% confidence intervals (CI). Results: Hyperthyroidism was diagnosed in 131 childhood cancer survivors, yielding an overall relative risk of 1.6 (95% CI: 1.3–1.9) compared with population comparisons. The risk was greatest 1–5 years after the diagnosis of cancer and in survivors of thyroid cancers, neuroblastomas, acute lymphoblastic leukaemia and Hodgkin lymphoma. Sixty-seven percent of survivors with hyperthyroidism had tumours located in the head, neck or upper body and half of survivors with hyperthyroidism were irradiated with 77% of them in the head and neck area. Conclusion: Childhood cancer survivors are at an increased risk of hyperthyroidism, potentially resulting in non-endocrine morbidity.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Oncologica
volume
58
issue
2
pages
227 - 231
publisher
Taylor & Francis
external identifiers
  • scopus:85059102831
ISSN
0284-186X
DOI
10.1080/0284186X.2018.1535187
language
English
LU publication?
yes
id
c478848c-5f11-4a90-8653-43f1f88f58cb
date added to LUP
2019-01-10 12:21:46
date last changed
2019-05-27 18:01:58
@article{c478848c-5f11-4a90-8653-43f1f88f58cb,
  abstract     = {<p>Background: Hyperthyroidism is a rare disorder which may negatively affect health and quality of life. Its occurrence in childhood cancer survivors has not previously been investigated in detail. Material and methods: In the hospital registers of the five Nordic countries, 32,944 childhood cancer survivors and 212,675 population comparisons were followed for the diagnosis of hyperthyroidism. Hospitalisation rates, standardised hospitalisation rate ratios and absolute excess risks were calculated with 95% confidence intervals (CI). Results: Hyperthyroidism was diagnosed in 131 childhood cancer survivors, yielding an overall relative risk of 1.6 (95% CI: 1.3–1.9) compared with population comparisons. The risk was greatest 1–5 years after the diagnosis of cancer and in survivors of thyroid cancers, neuroblastomas, acute lymphoblastic leukaemia and Hodgkin lymphoma. Sixty-seven percent of survivors with hyperthyroidism had tumours located in the head, neck or upper body and half of survivors with hyperthyroidism were irradiated with 77% of them in the head and neck area. Conclusion: Childhood cancer survivors are at an increased risk of hyperthyroidism, potentially resulting in non-endocrine morbidity.</p>},
  author       = {Clausen, Camilla T. and Hasle, Henrik and Holmqvist, Anna S. and Madanat-Harjuoja, Laura and Tryggvadottir, Laufey and Wesenberg, Finn and Bautz, Andrea and Winther, Jeanette F. and Licht, Sofie de Fine},
  issn         = {0284-186X},
  language     = {eng},
  number       = {2},
  pages        = {227--231},
  publisher    = {Taylor & Francis},
  series       = {Acta Oncologica},
  title        = {Hyperthyroidism as a late effect in childhood cancer survivors - an Adult Life after Childhood Cancer in Scandinavia (ALiCCS) study},
  url          = {http://dx.doi.org/10.1080/0284186X.2018.1535187},
  volume       = {58},
  year         = {2019},
}