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High exposure to perfluorinated compounds in drinking water and thyroid disease. A cohort study from Ronneby, Sweden

Andersson, Eva M. ; Scott, Kristin LU ; Xu, Yi Yi ; Li, Ying ; Olsson, Daniel S. ; Fletcher, Tony and Jakobsson, Kristina LU (2019) In Environmental Research 176.
Abstract

Per- and polyfluoroalkyl substances (PFAS) are extremely persistent manmade substances. Apart from exposure through food and indoor air and dust, humans can be exposed through drinking water if the surface or groundwater is contaminated. In 2013 very high levels of PFOS and PFHxS were found in the drinking water from one of the two waterworks supplying the municipality of Ronneby, Sweden. A cohort was formed, including all individuals who had lived at least one year in Ronneby during the period 1980–2013 (ñ63,000). Each year, addresses that got their drinking water from the contaminated water works were identified. Through the Swedish personal identity number, each individual was linked to registers providing diagnoses and prescriptions... (More)

Per- and polyfluoroalkyl substances (PFAS) are extremely persistent manmade substances. Apart from exposure through food and indoor air and dust, humans can be exposed through drinking water if the surface or groundwater is contaminated. In 2013 very high levels of PFOS and PFHxS were found in the drinking water from one of the two waterworks supplying the municipality of Ronneby, Sweden. A cohort was formed, including all individuals who had lived at least one year in Ronneby during the period 1980–2013 (ñ63,000). Each year, addresses that got their drinking water from the contaminated water works were identified. Through the Swedish personal identity number, each individual was linked to registers providing diagnoses and prescriptions for hyper- and hypothyroidism. In total, 16,150 individuals had ever been exposed. The hazard ratios did not indicate any excess risk of hyperthyroidism among those with contaminated water. For hypothyroidism, the risk of being prescribed medication was significantly increased among women with exposure during the mid part of the study period (but not men). However, the association with period of exposure was non-monotonic, so the significance is considered to be a chance finding. Our research was limited by the relatively simple exposure assessment.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Cohort study, Drinking water, Per- and polyfluoroalkyl substances (PFAS), Register study, Thyroid disease
in
Environmental Research
volume
176
article number
108540
publisher
Elsevier
external identifiers
  • scopus:85067669285
ISSN
0013-9351
DOI
10.1016/j.envres.2019.108540
language
English
LU publication?
yes
id
c482dce0-3d06-4697-9fb5-686155b2b0b3
date added to LUP
2019-07-04 13:29:25
date last changed
2019-12-03 02:15:59
@article{c482dce0-3d06-4697-9fb5-686155b2b0b3,
  abstract     = {<p>Per- and polyfluoroalkyl substances (PFAS) are extremely persistent manmade substances. Apart from exposure through food and indoor air and dust, humans can be exposed through drinking water if the surface or groundwater is contaminated. In 2013 very high levels of PFOS and PFHxS were found in the drinking water from one of the two waterworks supplying the municipality of Ronneby, Sweden. A cohort was formed, including all individuals who had lived at least one year in Ronneby during the period 1980–2013 (ñ63,000). Each year, addresses that got their drinking water from the contaminated water works were identified. Through the Swedish personal identity number, each individual was linked to registers providing diagnoses and prescriptions for hyper- and hypothyroidism. In total, 16,150 individuals had ever been exposed. The hazard ratios did not indicate any excess risk of hyperthyroidism among those with contaminated water. For hypothyroidism, the risk of being prescribed medication was significantly increased among women with exposure during the mid part of the study period (but not men). However, the association with period of exposure was non-monotonic, so the significance is considered to be a chance finding. Our research was limited by the relatively simple exposure assessment.</p>},
  author       = {Andersson, Eva M. and Scott, Kristin and Xu, Yi Yi and Li, Ying and Olsson, Daniel S. and Fletcher, Tony and Jakobsson, Kristina},
  issn         = {0013-9351},
  language     = {eng},
  publisher    = {Elsevier},
  series       = {Environmental Research},
  title        = {High exposure to perfluorinated compounds in drinking water and thyroid disease. A cohort study from Ronneby, Sweden},
  url          = {http://dx.doi.org/10.1016/j.envres.2019.108540},
  doi          = {10.1016/j.envres.2019.108540},
  volume       = {176},
  year         = {2019},
}