Infertility-Causing Haploinsufficiency Reveals TRIM28/KAP1 Requirement in Spermatogonia
Tan, Joel H L ; Wollmann, Heike ; van Pelt, Ans M M ; Kaldis, Philipp LU
and Messerschmidt, Daniel M
(2020)
In Stem Cell Reports
14(5).
p.818-827
- Abstract
Spermatogenesis relies on exquisite stem cell homeostasis, the carefully balanced self-renewal and differentiation of spermatogonial stem cells (SSCs). Disturbing this equilibrium will likely manifest through sub- or infertility, a global health issue with often idiopathic presentation. In this respect, disease phenotypes caused by haploinsufficiency of otherwise vital developmental genes are of particular interest. Here, we show that mice heterozygous for Trim28, an essential epigenetic regulator, suffer gradual testicular degeneration. Contrary to previous reports we detect Trim28 expression in spermatogonia, albeit at low levels. Further reduction through Trim28 heterozygosity increases the propensity of SSCs to differentiate at the... (More)
Spermatogenesis relies on exquisite stem cell homeostasis, the carefully balanced self-renewal and differentiation of spermatogonial stem cells (SSCs). Disturbing this equilibrium will likely manifest through sub- or infertility, a global health issue with often idiopathic presentation. In this respect, disease phenotypes caused by haploinsufficiency of otherwise vital developmental genes are of particular interest. Here, we show that mice heterozygous for Trim28, an essential epigenetic regulator, suffer gradual testicular degeneration. Contrary to previous reports we detect Trim28 expression in spermatogonia, albeit at low levels. Further reduction through Trim28 heterozygosity increases the propensity of SSCs to differentiate at the cost of self-renewal.
(Less)
- author
- Tan, Joel H L
; Wollmann, Heike
; van Pelt, Ans M M
; Kaldis, Philipp
LU
and Messerschmidt, Daniel M
- publishing date
- 2020-04-01
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Stem Cell Reports
- volume
- 14
- issue
- 5
- pages
- 818 - 827
- publisher
- Cell Press
- external identifiers
-
- scopus:85084694921
- pmid:32302554
- ISSN
- 2213-6711
- DOI
- 10.1016/j.stemcr.2020.03.013
- language
- English
- LU publication?
- no
- additional info
- Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved.
- id
- c49d41b9-3583-4731-9eef-7bf61e75347e
- date added to LUP
- 2020-04-27 14:12:05
- date last changed
- 2024-09-04 20:59:41
@article{c49d41b9-3583-4731-9eef-7bf61e75347e,
abstract = {{<p>Spermatogenesis relies on exquisite stem cell homeostasis, the carefully balanced self-renewal and differentiation of spermatogonial stem cells (SSCs). Disturbing this equilibrium will likely manifest through sub- or infertility, a global health issue with often idiopathic presentation. In this respect, disease phenotypes caused by haploinsufficiency of otherwise vital developmental genes are of particular interest. Here, we show that mice heterozygous for Trim28, an essential epigenetic regulator, suffer gradual testicular degeneration. Contrary to previous reports we detect Trim28 expression in spermatogonia, albeit at low levels. Further reduction through Trim28 heterozygosity increases the propensity of SSCs to differentiate at the cost of self-renewal.</p>}},
author = {{Tan, Joel H L and Wollmann, Heike and van Pelt, Ans M M and Kaldis, Philipp and Messerschmidt, Daniel M}},
issn = {{2213-6711}},
language = {{eng}},
month = {{04}},
number = {{5}},
pages = {{818--827}},
publisher = {{Cell Press}},
series = {{Stem Cell Reports}},
title = {{Infertility-Causing Haploinsufficiency Reveals TRIM28/KAP1 Requirement in Spermatogonia}},
url = {{http://dx.doi.org/10.1016/j.stemcr.2020.03.013}},
doi = {{10.1016/j.stemcr.2020.03.013}},
volume = {{14}},
year = {{2020}},
}