Best practices for cystometric evaluation of lower urinary tract function in muriform rodents
Fraser, Matthew O. ; Smith, Phillip P. ; Sullivan, Maryrose P. ; Bjorling, Dale E. ; Campeau, Lysanne ; Andersson, Karl Erik LU
and Yoshiyama, Mitsuharu
(2020)
In Neurourology and Urodynamics
39(6).
p.1868-1884
- Abstract
Aims: Rodent cystometry has provided valuable insights into the impact of the disease, injury, and aging on the cellular and molecular pathways, neurologic processes, and biomechanics of lower urinary tract function. The purpose of this white paper is to highlight the benefits and shortcomings of different experimental methods and strategies and to provide guidance on the proper interpretation of results. Methods: Literature search, selection of articles, and conclusions based on discussions among a panel of workers in the field. Results: A range of cystometric tests and techniques used to explore biological phenomena relevant to the lower urinary tract are described, the advantages and disadvantages of various experimental conditions... (More)
Aims: Rodent cystometry has provided valuable insights into the impact of the disease, injury, and aging on the cellular and molecular pathways, neurologic processes, and biomechanics of lower urinary tract function. The purpose of this white paper is to highlight the benefits and shortcomings of different experimental methods and strategies and to provide guidance on the proper interpretation of results. Methods: Literature search, selection of articles, and conclusions based on discussions among a panel of workers in the field. Results: A range of cystometric tests and techniques used to explore biological phenomena relevant to the lower urinary tract are described, the advantages and disadvantages of various experimental conditions are discussed, and guidance on the practical aspects of experimental execution and proper interpretation of results are provided. Conclusions: Cystometric evaluation of rodents comprises an extensive collection of functional tests that can be performed under a variety of experimental conditions. Decisions regarding which approaches to choose should be determined by the specific questions to be addressed and implementation of the test should follow standardized procedures.
(Less)
- author
- Fraser, Matthew O.
; Smith, Phillip P.
; Sullivan, Maryrose P.
; Bjorling, Dale E.
; Campeau, Lysanne
; Andersson, Karl Erik
LU
and Yoshiyama, Mitsuharu
- organization
- publishing date
- 2020-08
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- preclinical research, rodent cystometry, urethra, urinary bladder, urodynamics, white paper
- in
- Neurourology and Urodynamics
- volume
- 39
- issue
- 6
- pages
- 17 pages
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- scopus:85086085409
- pmid:32511810
- ISSN
- 0733-2467
- DOI
- 10.1002/nau.24415
- language
- English
- LU publication?
- yes
- id
- c4ab7ff6-1a19-4e2e-8491-13fe522fdfbf
- date added to LUP
- 2020-06-29 15:13:40
- date last changed
- 2024-04-03 09:02:42
@article{c4ab7ff6-1a19-4e2e-8491-13fe522fdfbf,
abstract = {{<p>Aims: Rodent cystometry has provided valuable insights into the impact of the disease, injury, and aging on the cellular and molecular pathways, neurologic processes, and biomechanics of lower urinary tract function. The purpose of this white paper is to highlight the benefits and shortcomings of different experimental methods and strategies and to provide guidance on the proper interpretation of results. Methods: Literature search, selection of articles, and conclusions based on discussions among a panel of workers in the field. Results: A range of cystometric tests and techniques used to explore biological phenomena relevant to the lower urinary tract are described, the advantages and disadvantages of various experimental conditions are discussed, and guidance on the practical aspects of experimental execution and proper interpretation of results are provided. Conclusions: Cystometric evaluation of rodents comprises an extensive collection of functional tests that can be performed under a variety of experimental conditions. Decisions regarding which approaches to choose should be determined by the specific questions to be addressed and implementation of the test should follow standardized procedures.</p>}},
author = {{Fraser, Matthew O. and Smith, Phillip P. and Sullivan, Maryrose P. and Bjorling, Dale E. and Campeau, Lysanne and Andersson, Karl Erik and Yoshiyama, Mitsuharu}},
issn = {{0733-2467}},
keywords = {{preclinical research; rodent cystometry; urethra; urinary bladder; urodynamics; white paper}},
language = {{eng}},
number = {{6}},
pages = {{1868--1884}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Neurourology and Urodynamics}},
title = {{Best practices for cystometric evaluation of lower urinary tract function in muriform rodents}},
url = {{http://dx.doi.org/10.1002/nau.24415}},
doi = {{10.1002/nau.24415}},
volume = {{39}},
year = {{2020}},
}