The role of T cells and myeloid-derived suppressor cells in refractory immune thrombocytopenia
(2023) In British Journal of Haematology 203(1). p.54-61- Abstract
Immune thrombocytopenia (ITP) is characterized by a dysregulated immune response against platelets, affecting both their destruction and production. A role for an abnormal T-cell compartment has been established in ITP pathogenesis and treatments that increase platelet counts in patients with ITP have shown improvements in T-cell profiles. On the other hand, patients who were refractory to treatment appear to retain the T-cell abnormalities as before. Myeloid-derived suppressive cells (MDSCs) are also emerging as key contributors to the immune pathology of ITP and response to treatment. In this review, we will discuss how various treatments affect the T-cell and MDSC compartments in ITP. The review will focus on studies that have... (More)
Immune thrombocytopenia (ITP) is characterized by a dysregulated immune response against platelets, affecting both their destruction and production. A role for an abnormal T-cell compartment has been established in ITP pathogenesis and treatments that increase platelet counts in patients with ITP have shown improvements in T-cell profiles. On the other hand, patients who were refractory to treatment appear to retain the T-cell abnormalities as before. Myeloid-derived suppressive cells (MDSCs) are also emerging as key contributors to the immune pathology of ITP and response to treatment. In this review, we will discuss how various treatments affect the T-cell and MDSC compartments in ITP. The review will focus on studies that have examined the underlying mechanisms and/or genetic basis responsible for refractoriness to a given treatment and highlight remaining challenges in identifying factors and mechanisms to predict response to treatment.
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- author
- Yazdanbakhsh, Karina ; Provan, Drew and Semple, John W. LU
- organization
- publishing date
- 2023-10
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- myeloid-derived suppressive cells, refractory immune thrombocytopenia, responder/non-responder, role of T cells, T regulatory, thrombopoietin receptor agonists
- in
- British Journal of Haematology
- volume
- 203
- issue
- 1
- pages
- 8 pages
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:37735552
- scopus:85171829779
- ISSN
- 0007-1048
- DOI
- 10.1111/bjh.19079
- language
- English
- LU publication?
- yes
- id
- c4dfbc94-cbc0-4f77-bf3a-63297cc354c5
- date added to LUP
- 2023-12-07 09:32:37
- date last changed
- 2024-04-20 03:54:40
@article{c4dfbc94-cbc0-4f77-bf3a-63297cc354c5,
abstract = {{<p>Immune thrombocytopenia (ITP) is characterized by a dysregulated immune response against platelets, affecting both their destruction and production. A role for an abnormal T-cell compartment has been established in ITP pathogenesis and treatments that increase platelet counts in patients with ITP have shown improvements in T-cell profiles. On the other hand, patients who were refractory to treatment appear to retain the T-cell abnormalities as before. Myeloid-derived suppressive cells (MDSCs) are also emerging as key contributors to the immune pathology of ITP and response to treatment. In this review, we will discuss how various treatments affect the T-cell and MDSC compartments in ITP. The review will focus on studies that have examined the underlying mechanisms and/or genetic basis responsible for refractoriness to a given treatment and highlight remaining challenges in identifying factors and mechanisms to predict response to treatment.</p>}},
author = {{Yazdanbakhsh, Karina and Provan, Drew and Semple, John W.}},
issn = {{0007-1048}},
keywords = {{myeloid-derived suppressive cells; refractory immune thrombocytopenia; responder/non-responder; role of T cells; T regulatory; thrombopoietin receptor agonists}},
language = {{eng}},
number = {{1}},
pages = {{54--61}},
publisher = {{Wiley-Blackwell}},
series = {{British Journal of Haematology}},
title = {{The role of T cells and myeloid-derived suppressor cells in refractory immune thrombocytopenia}},
url = {{http://dx.doi.org/10.1111/bjh.19079}},
doi = {{10.1111/bjh.19079}},
volume = {{203}},
year = {{2023}},
}