Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Soluble CD163 and glycated haemoglobin were independently associated with the progression of diabetic retinopathy in adult patients with type 1 diabetes

Hector, Sven LU ; Thulesius, Hans Olav LU ; Landin-Olsson, Mona LU ; Hillman, Magnus LU and Melin, Eva Olga LU (2023) In BMJ Open Ophthalmology 8(1).
Abstract

Objective High vitreous levels of soluble (s)CD163 have been demonstrated in severe diabetic retinopathy (DR). The aim of this study was to explore the predictive values of plasma sCD163 and glycated haemoglobin (HbA1c) for DR progression in adults with type 1 diabetes. Methods and analyses The study design was prospective. Fundus photography performed in 2009 and at follow-up (≤12 years later) were compared after being categorised according to the International Clinical Diabetic Retinopathy Disease Severity Scale. 'DR progression at least one level' was calculated. In 2009, data collection (sex, age, diabetes duration, metabolic variables, serum creatinine, macroalbuminuria and lifestyle factors) and biochemical analyses were... (More)

Objective High vitreous levels of soluble (s)CD163 have been demonstrated in severe diabetic retinopathy (DR). The aim of this study was to explore the predictive values of plasma sCD163 and glycated haemoglobin (HbA1c) for DR progression in adults with type 1 diabetes. Methods and analyses The study design was prospective. Fundus photography performed in 2009 and at follow-up (≤12 years later) were compared after being categorised according to the International Clinical Diabetic Retinopathy Disease Severity Scale. 'DR progression at least one level' was calculated. In 2009, data collection (sex, age, diabetes duration, metabolic variables, serum creatinine, macroalbuminuria and lifestyle factors) and biochemical analyses were performed. Plasma sCD163 and HbA1c were divided into quartiles. Logistic regression analyses were performed. Results The prevalence of DR in 2009 versus at follow-up in 270 participants (57% male) were: no apparent 28% vs 18%; mild 20% vs 13%; moderate 24% vs 26%; severe 11% vs 13%; and proliferative DR 17% vs 30% (p<0.001). DR progression occurred in 101 (45%) patients. HbA1c ≥54 mmol/mol (≥7.1%) (>1st quartile) (adjusted odds ratio (AOR) 3.8, p<0.001) and sCD163 ≥343 ng/mL (>1st quartile) (AOR 2.6, p=0.004) were independently associated with DR progression. The associations with DR progression increased significantly from the first to the fourth quartile for HbA1c (AORs: 1; 2.5; 3.6; 7.4), but not for sCD163 (AORs: 1; 2.9; 2.4; 2.4). Conclusion Plasma sCD163 may constitute a valuable biomarker for DR progression in addition to and independent of the well-established biomarker HbA1c.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Biochemical marker - diabetic retinopathy - follow-up study - glycated haemoglobin - inflammation - CD163 protein, human - diabetes mellitus type 1
in
BMJ Open Ophthalmology
volume
8
issue
1
article number
001314
publisher
BMJ Publishing Group
external identifiers
  • pmid:37493689
  • scopus:85165602824
ISSN
2397-3269
DOI
10.1136/bmjophth-2023-001314
language
English
LU publication?
yes
additional info
Funding Information: The research was supported by the Research and Development fund of Region Kronoberg, Växjö, Sweden. Grant numbers 936015 (March 2020) and 969355 (October 2021). The funding source was not involved in the collection, analysis or interpretation of data, in the writing of the report, or in the decision to submit the article for publication. Publisher Copyright: © Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
id
c5032c76-0d72-4def-8f62-ef4558f2d708
date added to LUP
2023-08-22 09:45:58
date last changed
2024-04-20 01:11:37
@article{c5032c76-0d72-4def-8f62-ef4558f2d708,
  abstract     = {{<p>Objective High vitreous levels of soluble (s)CD163 have been demonstrated in severe diabetic retinopathy (DR). The aim of this study was to explore the predictive values of plasma sCD163 and glycated haemoglobin (HbA1c) for DR progression in adults with type 1 diabetes. Methods and analyses The study design was prospective. Fundus photography performed in 2009 and at follow-up (≤12 years later) were compared after being categorised according to the International Clinical Diabetic Retinopathy Disease Severity Scale. 'DR progression at least one level' was calculated. In 2009, data collection (sex, age, diabetes duration, metabolic variables, serum creatinine, macroalbuminuria and lifestyle factors) and biochemical analyses were performed. Plasma sCD163 and HbA1c were divided into quartiles. Logistic regression analyses were performed. Results The prevalence of DR in 2009 versus at follow-up in 270 participants (57% male) were: no apparent 28% vs 18%; mild 20% vs 13%; moderate 24% vs 26%; severe 11% vs 13%; and proliferative DR 17% vs 30% (p&lt;0.001). DR progression occurred in 101 (45%) patients. HbA1c ≥54 mmol/mol (≥7.1%) (&gt;1st quartile) (adjusted odds ratio (AOR) 3.8, p&lt;0.001) and sCD163 ≥343 ng/mL (&gt;1st quartile) (AOR 2.6, p=0.004) were independently associated with DR progression. The associations with DR progression increased significantly from the first to the fourth quartile for HbA1c (AORs: 1; 2.5; 3.6; 7.4), but not for sCD163 (AORs: 1; 2.9; 2.4; 2.4). Conclusion Plasma sCD163 may constitute a valuable biomarker for DR progression in addition to and independent of the well-established biomarker HbA1c.</p>}},
  author       = {{Hector, Sven and Thulesius, Hans Olav and Landin-Olsson, Mona and Hillman, Magnus and Melin, Eva Olga}},
  issn         = {{2397-3269}},
  keywords     = {{Biochemical marker - diabetic retinopathy - follow-up study - glycated haemoglobin - inflammation - CD163 protein; human - diabetes mellitus type 1}},
  language     = {{eng}},
  month        = {{07}},
  number       = {{1}},
  publisher    = {{BMJ Publishing Group}},
  series       = {{BMJ Open Ophthalmology}},
  title        = {{Soluble CD163 and glycated haemoglobin were independently associated with the progression of diabetic retinopathy in adult patients with type 1 diabetes}},
  url          = {{http://dx.doi.org/10.1136/bmjophth-2023-001314}},
  doi          = {{10.1136/bmjophth-2023-001314}},
  volume       = {{8}},
  year         = {{2023}},
}