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Ny markør ved trombotisk trombocytopenisk purpura

Gøtze, Jens Peter ; Hillarp, Andreas LU ; Lindblom, Anders ; Björk, Peter LU ; Strandberg, Karin LU and Nielsen, Lars Bo LU (2008) In Ugeskrift for Laeger 170(33). p.9-2446
Abstract

Thrombotic microangiopathy can be caused by several conditions which are difficult to diagnose from the clinical presentation alone. Deficient enzyme activity of a newly-discovered enzyme, ADAMTS-13, can lead to thrombotic thrombocytopenic purpura (TTP). Lack of ADAMTS-13 activity causes increased concentrations of high molecular weight von Willebrand factor forms and increased platelet aggregation. Measurement of ADAMTS-13 activity is useful for the diagnosis of TTP and may also be relevant as a prognostic test for recurrent TTP.

Abstract (Swedish)
Der findes flere trombotiske mikroangiopatier, som kan være
svære at adskille ud fra den kliniske præsentation. Mangel på et
nyopdaget enzym, a disintegrin and metalloprotease with throm-
bospondin type 1 motifs (ADAMTS)-13, kan forårsage trombotisk
trombocytopenisk purpura (TTP). Mangel på ADAMTS-13 fører til
øgede koncentrationer af højmolekylære von Willebrand-faktor-
former i plasma og fremmer dannelse af trombose i mikrovasku-
laturen. ADAMTS-13-mangel kan være arvelig eller erhvervet. Nye
metoder til bestemmelse af ADAMTS-13-aktivitet i plasma kan
bidrage i den diagnostiske proces ved mistanke om TTP
Please use this url to cite or link to this publication:
author
; ; ; ; and
organization
alternative title
New marker in thrombotic thrombocytopenic purpura
publishing date
type
Contribution to journal
publication status
published
subject
keywords
ADAM Proteins/blood, ADAMTS13 Protein, Biomarkers/blood, Diagnosis, Differential, Humans, Purpura, Thrombotic Thrombocytopenic/blood, von Willebrand Factor/genetics
in
Ugeskrift for Laeger
volume
170
issue
33
pages
4 pages
publisher
Den Almindelige Danske Lægeforening
external identifiers
  • scopus:49949097955
  • pmid:18761827
ISSN
0041-5782
language
Danish
LU publication?
yes
id
c519a1c7-8c3f-427f-b5e5-794b17d94276
alternative location
https://ugeskriftet.dk/files/scientific_article_files/2013-11//artikel_3626.pdf
date added to LUP
2022-08-29 10:12:35
date last changed
2025-01-12 22:12:39
@article{c519a1c7-8c3f-427f-b5e5-794b17d94276,
  abstract     = {{<p>Thrombotic microangiopathy can be caused by several conditions which are difficult to diagnose from the clinical presentation alone. Deficient enzyme activity of a newly-discovered enzyme, ADAMTS-13, can lead to thrombotic thrombocytopenic purpura (TTP). Lack of ADAMTS-13 activity causes increased concentrations of high molecular weight von Willebrand factor forms and increased platelet aggregation. Measurement of ADAMTS-13 activity is useful for the diagnosis of TTP and may also be relevant as a prognostic test for recurrent TTP.</p>}},
  author       = {{Gøtze, Jens Peter and Hillarp, Andreas and Lindblom, Anders and Björk, Peter and Strandberg, Karin and Nielsen, Lars Bo}},
  issn         = {{0041-5782}},
  keywords     = {{ADAM Proteins/blood; ADAMTS13 Protein; Biomarkers/blood; Diagnosis, Differential; Humans; Purpura, Thrombotic Thrombocytopenic/blood; von Willebrand Factor/genetics}},
  language     = {{dan}},
  month        = {{08}},
  number       = {{33}},
  pages        = {{9--2446}},
  publisher    = {{Den Almindelige Danske Lægeforening}},
  series       = {{Ugeskrift for Laeger}},
  title        = {{Ny markør ved trombotisk trombocytopenisk purpura}},
  url          = {{https://ugeskriftet.dk/files/scientific_article_files/2013-11//artikel_3626.pdf}},
  volume       = {{170}},
  year         = {{2008}},
}