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Assessment of denosumab treatment effects and imaging response in patients with giant cell tumor of bone 11 Medical and Health Sciences 1103 Clinical Sciences

Engellau, Jacob LU ; Seeger, Leanne ; Grimer, Robert ; Henshaw, Robert ; Gelderblom, Hans ; Choy, Edwin ; Chawla, Sant ; Reichardt, Peter ; O'Neal, Michael and Feng, Amy , et al. (2018) In World Journal of Surgical Oncology 16(1).
Abstract

Background: Denosumab has been shown to reduce tumor size and progression, reform mineralized bone, and increase intralesional bone density in patients with giant cell tumor of bone (GCTB); however, radiologic assessment of tumors in bone is challenging. The study objective was to assess tumor response to denosumab using three different imaging parameters in a prespecified analysis in patients with GCTB from two phase 2 studies. Methods: The studies enrolled adults and adolescents (skeletally mature and at least 12 years of age) with radiographically measurable GCTB that were given denosumab 120 mg every 4 weeks, with additional doses on days 8 and 15 of cycle 1. The proportion of patients with an objective tumor response was assessed... (More)

Background: Denosumab has been shown to reduce tumor size and progression, reform mineralized bone, and increase intralesional bone density in patients with giant cell tumor of bone (GCTB); however, radiologic assessment of tumors in bone is challenging. The study objective was to assess tumor response to denosumab using three different imaging parameters in a prespecified analysis in patients with GCTB from two phase 2 studies. Methods: The studies enrolled adults and adolescents (skeletally mature and at least 12 years of age) with radiographically measurable GCTB that were given denosumab 120 mg every 4 weeks, with additional doses on days 8 and 15 of cycle 1. The proportion of patients with an objective tumor response was assessed using either Response Evaluation Criteria in Solid Tumors version 1.1 (RECIST), European Organisation for Research and Treatment of Cancer response criteria (positron emission tomography [PET] scan criteria), or inverse Choi density/size (ICDS) criteria. Target lesions were measured by computed tomography or magnetic resonance imaging (both studies), PET (study 2 only), or plain film radiograph (study 2 only). Results: Most patients (71.6%) had an objective tumor response by at least one response criteria. Per RECIST, 25.1% of patients had a response; per PET scan criteria, 96.2% had a response; per ICDS, 76.1% had a response. 68.5% had an objective tumor response ≥ 24 weeks. Using any criteria, crude incidence of response ranged from 56% (vertebrae/skull) to 91% (lung/soft tissue), and 98.2% had tumor control ≥ 24 weeks. Reduced PET avidity appeared to be an early sign of response to denosumab treatment. Conclusion: Modified PET scan criteria and ICDS criteria indicate that most patients show responses and higher benefit rates than modified RECIST, and therefore may be useful for early assessment of response to denosumab. Trial registration: ClinicalTrials.gov Clinical Trials Registry NCT00396279 (retrospectively registered November 6, 2006) and NCT00680992 (retrospectively registered May 20, 2008).

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publishing date
type
Contribution to journal
publication status
published
subject
keywords
Denosumab, Giant cell tumor of bone, Objective tumor response, RANKL
in
World Journal of Surgical Oncology
volume
16
issue
1
article number
191
publisher
BioMed Central (BMC)
external identifiers
  • scopus:85053658309
  • pmid:30231890
ISSN
1477-7819
DOI
10.1186/s12957-018-1478-3
language
English
LU publication?
no
id
c525b35f-4564-4270-aa09-1929bdd54cda
date added to LUP
2018-10-11 07:48:58
date last changed
2024-05-27 18:35:06
@article{c525b35f-4564-4270-aa09-1929bdd54cda,
  abstract     = {{<p>Background: Denosumab has been shown to reduce tumor size and progression, reform mineralized bone, and increase intralesional bone density in patients with giant cell tumor of bone (GCTB); however, radiologic assessment of tumors in bone is challenging. The study objective was to assess tumor response to denosumab using three different imaging parameters in a prespecified analysis in patients with GCTB from two phase 2 studies. Methods: The studies enrolled adults and adolescents (skeletally mature and at least 12 years of age) with radiographically measurable GCTB that were given denosumab 120 mg every 4 weeks, with additional doses on days 8 and 15 of cycle 1. The proportion of patients with an objective tumor response was assessed using either Response Evaluation Criteria in Solid Tumors version 1.1 (RECIST), European Organisation for Research and Treatment of Cancer response criteria (positron emission tomography [PET] scan criteria), or inverse Choi density/size (ICDS) criteria. Target lesions were measured by computed tomography or magnetic resonance imaging (both studies), PET (study 2 only), or plain film radiograph (study 2 only). Results: Most patients (71.6%) had an objective tumor response by at least one response criteria. Per RECIST, 25.1% of patients had a response; per PET scan criteria, 96.2% had a response; per ICDS, 76.1% had a response. 68.5% had an objective tumor response ≥ 24 weeks. Using any criteria, crude incidence of response ranged from 56% (vertebrae/skull) to 91% (lung/soft tissue), and 98.2% had tumor control ≥ 24 weeks. Reduced PET avidity appeared to be an early sign of response to denosumab treatment. Conclusion: Modified PET scan criteria and ICDS criteria indicate that most patients show responses and higher benefit rates than modified RECIST, and therefore may be useful for early assessment of response to denosumab. Trial registration: ClinicalTrials.gov Clinical Trials Registry NCT00396279 (retrospectively registered November 6, 2006) and NCT00680992 (retrospectively registered May 20, 2008).</p>}},
  author       = {{Engellau, Jacob and Seeger, Leanne and Grimer, Robert and Henshaw, Robert and Gelderblom, Hans and Choy, Edwin and Chawla, Sant and Reichardt, Peter and O'Neal, Michael and Feng, Amy and Jacobs, Ira and Roberts, Zachary J. and Braun, Ada and Bach, Bruce A.}},
  issn         = {{1477-7819}},
  keywords     = {{Denosumab; Giant cell tumor of bone; Objective tumor response; RANKL}},
  language     = {{eng}},
  month        = {{09}},
  number       = {{1}},
  publisher    = {{BioMed Central (BMC)}},
  series       = {{World Journal of Surgical Oncology}},
  title        = {{Assessment of denosumab treatment effects and imaging response in patients with giant cell tumor of bone 11 Medical and Health Sciences 1103 Clinical Sciences}},
  url          = {{http://dx.doi.org/10.1186/s12957-018-1478-3}},
  doi          = {{10.1186/s12957-018-1478-3}},
  volume       = {{16}},
  year         = {{2018}},
}