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Irreversible Kidney Damage due to Multicentric Castleman's Disease

Kahn, Fredrik LU ; Fagerström, Anna; Segelmark, Mårten LU and Bakoush, Omran LU (2008) In Libyan Journal of Medicine 3(2). p.3-101
Abstract

Castleman's Disease (CD) is a rare lymphoproliferative disorder accompanied by marked systemic inflammatory response. Morphological diagnosis of CD requires biopsy of the whole of the involved lymph node tissue. Three histologic variants have already been described in CD morphology (hyaline vascular, plasma-cell, and mixed). In this study, we report a case of a multicentric Castleman's disease of the plasma cell variant type with negative Herpes Virus 8. The clinical presentation of this patient was of systemic amyloidosis as a result of both a delayed diagnosis and medical management. Previously described cases of CD with secondary amyloidosis have been of the localized type. Regardless, long-standing clinical remission of CD by... (More)

Castleman's Disease (CD) is a rare lymphoproliferative disorder accompanied by marked systemic inflammatory response. Morphological diagnosis of CD requires biopsy of the whole of the involved lymph node tissue. Three histologic variants have already been described in CD morphology (hyaline vascular, plasma-cell, and mixed). In this study, we report a case of a multicentric Castleman's disease of the plasma cell variant type with negative Herpes Virus 8. The clinical presentation of this patient was of systemic amyloidosis as a result of both a delayed diagnosis and medical management. Previously described cases of CD with secondary amyloidosis have been of the localized type. Regardless, long-standing clinical remission of CD by cytotoxic drugs and anti-CD20 antibody therapy was achieved, but the nephrotic syndrome remained irreversible.

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subject
keywords
Journal Article
in
Libyan Journal of Medicine
volume
3
issue
2
pages
3 pages
publisher
Univ Alfateh, Fac Med
ISSN
1993-2820
DOI
10.3402/ljm.v3i2.4766
language
English
LU publication?
no
id
c526411a-2b1a-421c-8c11-b416737448f0
date added to LUP
2017-03-14 14:42:54
date last changed
2017-03-15 10:38:48
@article{c526411a-2b1a-421c-8c11-b416737448f0,
  abstract     = {<p>Castleman's Disease (CD) is a rare lymphoproliferative disorder accompanied by marked systemic inflammatory response. Morphological diagnosis of CD requires biopsy of the whole of the involved lymph node tissue. Three histologic variants have already been described in CD morphology (hyaline vascular, plasma-cell, and mixed). In this study, we report a case of a multicentric Castleman's disease of the plasma cell variant type with negative Herpes Virus 8. The clinical presentation of this patient was of systemic amyloidosis as a result of both a delayed diagnosis and medical management. Previously described cases of CD with secondary amyloidosis have been of the localized type. Regardless, long-standing clinical remission of CD by cytotoxic drugs and anti-CD20 antibody therapy was achieved, but the nephrotic syndrome remained irreversible.</p>},
  author       = {Kahn, Fredrik and Fagerström, Anna and Segelmark, Mårten and Bakoush, Omran},
  issn         = {1993-2820},
  keyword      = {Journal Article},
  language     = {eng},
  month        = {06},
  number       = {2},
  pages        = {3--101},
  publisher    = {Univ Alfateh, Fac Med},
  series       = {Libyan Journal of Medicine},
  title        = {Irreversible Kidney Damage due to Multicentric Castleman's Disease},
  url          = {http://dx.doi.org/10.3402/ljm.v3i2.4766},
  volume       = {3},
  year         = {2008},
}