Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Repeated seasonal influenza vaccination among elderly in Europe: Effects on laboratory confirmed hospitalised influenza

Rondy, Marc ; Launay, Odile ; Castilla, Jesus ; Costanzo, Simona ; Puig-Barbera, Joan ; Gefenaite, Giedre LU orcid ; Laururi, Amparo ; Rizzo, Caterina ; Pitigoi, Daniela and K. Syrjänen, Ritva , et al. (2017) In Vaccine 35(34). p.4298-4306
Abstract
In Europe, annual influenza vaccination is recommended to elderly. From 2011 to 2014 and in 2015-16, we conducted a multicentre test negative case control study in hospitals of 11 European countries to measure influenza vaccine effectiveness (IVE) against laboratory confirmed hospitalised influenza among people aged ≥65years. We pooled four seasons data to measure IVE by past exposures to influenza vaccination. We swabbed patients admitted for clinical conditions related to influenza with onset of severe acute respiratory infection ≤7days before admission. Cases were patients RT-PCR positive for influenza virus and controls those negative for any influenza virus. We documented seasonal vaccination status for the current season and the two... (More)
In Europe, annual influenza vaccination is recommended to elderly. From 2011 to 2014 and in 2015-16, we conducted a multicentre test negative case control study in hospitals of 11 European countries to measure influenza vaccine effectiveness (IVE) against laboratory confirmed hospitalised influenza among people aged ≥65years. We pooled four seasons data to measure IVE by past exposures to influenza vaccination. We swabbed patients admitted for clinical conditions related to influenza with onset of severe acute respiratory infection ≤7days before admission. Cases were patients RT-PCR positive for influenza virus and controls those negative for any influenza virus. We documented seasonal vaccination status for the current season and the two previous seasons. We recruited 5295 patients over the four seasons, including 465A(H1N1)pdm09, 642A(H3N2), 278 B case-patients and 3910 controls. Among patients unvaccinated in both previous two seasons, current seasonal IVE (pooled across seasons) was 30% (95%CI: -35 to 64), 8% (95%CI: -94 to 56) and 33% (95%CI: -43 to 68) against influenza A(H1N1)pdm09, A(H3N2) and B respectively. Among patients vaccinated in both previous seasons, current seasonal IVE (pooled across seasons) was -1% (95%CI: -80 to 43), 37% (95%CI: 7-57) and 43% (95%CI: 1-68) against influenza A(H1N1)pdm09, A(H3N2) and B respectively. Our results suggest that, regardless of patients' recent vaccination history, current seasonal vaccine conferred some protection to vaccinated patients against hospitalisation with influenza A(H3N2) and B. Vaccination of patients already vaccinated in both the past two seasons did not seem to be effective against A(H1N1)pdm09. To better understand the effect of repeated vaccination, engaging in large cohort studies documenting exposures to vaccine and natural infection is needed. (Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; ; ; and , et al. (More)
; ; ; ; ; ; ; ; ; ; ; ; ; ; and (Less)
publishing date
type
Contribution to journal
publication status
published
subject
in
Vaccine
volume
35
issue
34
pages
4298 - 4306
publisher
Elsevier
external identifiers
  • scopus:85022092145
ISSN
1873-2518
DOI
10.1016/j.vaccine.2017.06.088
project
Infectious diseases surveillance, vaccine effectiveness and determinants of acceptance
language
English
LU publication?
no
id
c53d1eaa-fcb7-40ff-ac32-1d6c8114aaea
date added to LUP
2022-02-01 12:10:01
date last changed
2023-02-02 17:43:14
@article{c53d1eaa-fcb7-40ff-ac32-1d6c8114aaea,
  abstract     = {{In Europe, annual influenza vaccination is recommended to elderly. From 2011 to 2014 and in 2015-16, we conducted a multicentre test negative case control study in hospitals of 11 European countries to measure influenza vaccine effectiveness (IVE) against laboratory confirmed hospitalised influenza among people aged ≥65years. We pooled four seasons data to measure IVE by past exposures to influenza vaccination. We swabbed patients admitted for clinical conditions related to influenza with onset of severe acute respiratory infection ≤7days before admission. Cases were patients RT-PCR positive for influenza virus and controls those negative for any influenza virus. We documented seasonal vaccination status for the current season and the two previous seasons. We recruited 5295 patients over the four seasons, including 465A(H1N1)pdm09, 642A(H3N2), 278 B case-patients and 3910 controls. Among patients unvaccinated in both previous two seasons, current seasonal IVE (pooled across seasons) was 30% (95%CI: -35 to 64), 8% (95%CI: -94 to 56) and 33% (95%CI: -43 to 68) against influenza A(H1N1)pdm09, A(H3N2) and B respectively. Among patients vaccinated in both previous seasons, current seasonal IVE (pooled across seasons) was -1% (95%CI: -80 to 43), 37% (95%CI: 7-57) and 43% (95%CI: 1-68) against influenza A(H1N1)pdm09, A(H3N2) and B respectively. Our results suggest that, regardless of patients' recent vaccination history, current seasonal vaccine conferred some protection to vaccinated patients against hospitalisation with influenza A(H3N2) and B. Vaccination of patients already vaccinated in both the past two seasons did not seem to be effective against A(H1N1)pdm09. To better understand the effect of repeated vaccination, engaging in large cohort studies documenting exposures to vaccine and natural infection is needed.}},
  author       = {{Rondy, Marc and Launay, Odile and Castilla, Jesus and Costanzo, Simona and Puig-Barbera, Joan and Gefenaite, Giedre and Laururi, Amparo and Rizzo, Caterina and Pitigoi, Daniela and K. Syrjänen, Ritva and Machado, Ausenda and Kurečić Filipović, S. and Horvath, Judit and Paradowska-Stankiewicz, Iwona and Marbus, Sierk and Moren, Alain}},
  issn         = {{1873-2518}},
  language     = {{eng}},
  month        = {{08}},
  number       = {{34}},
  pages        = {{4298--4306}},
  publisher    = {{Elsevier}},
  series       = {{Vaccine}},
  title        = {{Repeated seasonal influenza vaccination among elderly in Europe: Effects on laboratory confirmed hospitalised influenza}},
  url          = {{http://dx.doi.org/10.1016/j.vaccine.2017.06.088}},
  doi          = {{10.1016/j.vaccine.2017.06.088}},
  volume       = {{35}},
  year         = {{2017}},
}