A Pilot Study Examining Associations between DYRK1A and alpha-Synuclein Dementias
(2012) In Neurodegenerative Diseases 10(1-4). p.229-231- Abstract
- Background: DYRK1A is a kinase targeting several proteins associated with the pathology of dementias, including alpha-synuclein and amyloid precursor protein. It is not clear if DYRK1A genetics are associated with neurodegenerative conditions. Objective: To determine if DYRK1A also has a genetic association with alpha-synuclein dementias such as dementia with Lewy bodies and Parkinson's disease dementia. Methods: DNA samples from prospectively followed cohorts of control and dementia individuals were genotyped for the DYRK1A rs8126696 polymorphism. Results: The rs8126696 polymorphism altered the risk of developing an alpha-synuclein-associated dementia. Conclusion: DYRK1A could prove to be an important therapeutic target as it interacts... (More)
- Background: DYRK1A is a kinase targeting several proteins associated with the pathology of dementias, including alpha-synuclein and amyloid precursor protein. It is not clear if DYRK1A genetics are associated with neurodegenerative conditions. Objective: To determine if DYRK1A also has a genetic association with alpha-synuclein dementias such as dementia with Lewy bodies and Parkinson's disease dementia. Methods: DNA samples from prospectively followed cohorts of control and dementia individuals were genotyped for the DYRK1A rs8126696 polymorphism. Results: The rs8126696 polymorphism altered the risk of developing an alpha-synuclein-associated dementia. Conclusion: DYRK1A could prove to be an important therapeutic target as it interacts with several proteins associated with the development of pathology in dementia. Copyright (C) 2012 S. Karger AG, Basel (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2826896
- author
- Jones, Emma L. ; Aarsland, Dag ; Londos, Elisabet LU and Ballard, Clive
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Dementia with Lewy bodies, Parkinson's disease, Genetic association, alpha-Synuclein, DYRK1A
- in
- Neurodegenerative Diseases
- volume
- 10
- issue
- 1-4
- pages
- 229 - 231
- publisher
- Karger
- external identifiers
-
- wos:000303660600048
- scopus:84860220771
- ISSN
- 1660-2862
- DOI
- 10.1159/000334759
- language
- English
- LU publication?
- yes
- id
- c544053e-504b-40c9-8915-9c46d6c48ebb (old id 2826896)
- date added to LUP
- 2016-04-01 11:03:12
- date last changed
- 2022-01-26 04:59:35
@article{c544053e-504b-40c9-8915-9c46d6c48ebb,
abstract = {{Background: DYRK1A is a kinase targeting several proteins associated with the pathology of dementias, including alpha-synuclein and amyloid precursor protein. It is not clear if DYRK1A genetics are associated with neurodegenerative conditions. Objective: To determine if DYRK1A also has a genetic association with alpha-synuclein dementias such as dementia with Lewy bodies and Parkinson's disease dementia. Methods: DNA samples from prospectively followed cohorts of control and dementia individuals were genotyped for the DYRK1A rs8126696 polymorphism. Results: The rs8126696 polymorphism altered the risk of developing an alpha-synuclein-associated dementia. Conclusion: DYRK1A could prove to be an important therapeutic target as it interacts with several proteins associated with the development of pathology in dementia. Copyright (C) 2012 S. Karger AG, Basel}},
author = {{Jones, Emma L. and Aarsland, Dag and Londos, Elisabet and Ballard, Clive}},
issn = {{1660-2862}},
keywords = {{Dementia with Lewy bodies; Parkinson's disease; Genetic association; alpha-Synuclein; DYRK1A}},
language = {{eng}},
number = {{1-4}},
pages = {{229--231}},
publisher = {{Karger}},
series = {{Neurodegenerative Diseases}},
title = {{A Pilot Study Examining Associations between DYRK1A and alpha-Synuclein Dementias}},
url = {{http://dx.doi.org/10.1159/000334759}},
doi = {{10.1159/000334759}},
volume = {{10}},
year = {{2012}},
}