Genetic mouse models to investigate cell cycle regulation
Li, Weimin LU ; Kotoshiba, Shuhei and Kaldis, Philipp LU
(2009)
In Transgenic Research
18(4).
p.491-498
- Abstract
Early studies on cell cycle regulation were based on experiments in model systems (Yeast, Xenopus, Starfish, Drosophila) and have shaped the way we understand many events that control the cell cycle. Although these model systems are of great value, the last decade was highlighted by studies done in human cells and using in vivo mouse models. Mouse models are irreplaceable tools for understanding the genetics, development, and survival strategies of mammals. New developments in generating targeting vectors and mutant mice have improved our approaches to study cell cycle regulation and cancer. Here we summarize the most recent advances of mouse model approaches in dissecting the mechanisms of cell cycle regulation and the relevance to... (More)
Early studies on cell cycle regulation were based on experiments in model systems (Yeast, Xenopus, Starfish, Drosophila) and have shaped the way we understand many events that control the cell cycle. Although these model systems are of great value, the last decade was highlighted by studies done in human cells and using in vivo mouse models. Mouse models are irreplaceable tools for understanding the genetics, development, and survival strategies of mammals. New developments in generating targeting vectors and mutant mice have improved our approaches to study cell cycle regulation and cancer. Here we summarize the most recent advances of mouse model approaches in dissecting the mechanisms of cell cycle regulation and the relevance to human disease.
(Less)
- author
- Li, Weimin
LU
; Kotoshiba, Shuhei
and Kaldis, Philipp
LU
- publishing date
- 2009-06-01
- type
- Contribution to journal
- publication status
- published
- keywords
- Cell cycle regulation, Cre recombinase, ES cells, Frt recombinase, Genetic mouse models, Homologous recombination
- in
- Transgenic Research
- volume
- 18
- issue
- 4
- pages
- 491 - 498
- publisher
- Springer
- external identifiers
-
- pmid:19418238
- scopus:69449086034
- ISSN
- 0962-8819
- DOI
- 10.1007/s11248-009-9276-x
- language
- English
- LU publication?
- no
- id
- c554e980-ab70-4ebf-950e-1beebec139c8
- date added to LUP
- 2019-09-18 14:09:28
- date last changed
- 2024-01-01 20:38:18
@article{c554e980-ab70-4ebf-950e-1beebec139c8,
abstract = {{<p>Early studies on cell cycle regulation were based on experiments in model systems (Yeast, Xenopus, Starfish, Drosophila) and have shaped the way we understand many events that control the cell cycle. Although these model systems are of great value, the last decade was highlighted by studies done in human cells and using in vivo mouse models. Mouse models are irreplaceable tools for understanding the genetics, development, and survival strategies of mammals. New developments in generating targeting vectors and mutant mice have improved our approaches to study cell cycle regulation and cancer. Here we summarize the most recent advances of mouse model approaches in dissecting the mechanisms of cell cycle regulation and the relevance to human disease.</p>}},
author = {{Li, Weimin and Kotoshiba, Shuhei and Kaldis, Philipp}},
issn = {{0962-8819}},
keywords = {{Cell cycle regulation; Cre recombinase; ES cells; Frt recombinase; Genetic mouse models; Homologous recombination}},
language = {{eng}},
month = {{06}},
number = {{4}},
pages = {{491--498}},
publisher = {{Springer}},
series = {{Transgenic Research}},
title = {{Genetic mouse models to investigate cell cycle regulation}},
url = {{http://dx.doi.org/10.1007/s11248-009-9276-x}},
doi = {{10.1007/s11248-009-9276-x}},
volume = {{18}},
year = {{2009}},
}