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Growth hormone is secreted by normal breast epithelium upon progesterone stimulation and increases proliferation of stem/progenitor cells

Lombardi, Sara; Honeth, Gabriella LU ; Ginestier, Christophe; Shinomiya, Ireneusz; Marlow, Rebecca; Buchupalli, Bharath; Gazinska, Patrycja; Brown, John; Catchpole, Steven and Liu, Suling, et al. (2014) In Stem Cell Reports 2(6). p.93-780
Abstract

Using in vitro and in vivo experimental systems and in situ analysis, we show that growth hormone (GH) is secreted locally by normal human mammary epithelial cells upon progesterone stimulation. GH increases proliferation of a subset of cells that express growth hormone receptor (GHR) and have functional properties of stem and early progenitor cells. In 72% of ductal carcinoma in situ lesions, an expansion of the cell population that expresses GHR was observed, suggesting that GH signaling may contribute to breast cancer development.

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publication status
published
keywords
Cell Proliferation, Cells, Cultured, Human Growth Hormone, Humans, Mammary Glands, Human, Progesterone, Stem Cells, Journal Article, Research Support, Non-U.S. Gov't
in
Stem Cell Reports
volume
2
issue
6
pages
14 pages
publisher
Cell Press
external identifiers
  • scopus:84902204202
ISSN
2213-6711
DOI
10.1016/j.stemcr.2014.05.005
language
English
LU publication?
no
id
c587f856-f990-4dbc-ae05-22dc3c73f9f9
date added to LUP
2016-11-25 16:49:36
date last changed
2017-10-22 05:22:36
@article{c587f856-f990-4dbc-ae05-22dc3c73f9f9,
  abstract     = {<p>Using in vitro and in vivo experimental systems and in situ analysis, we show that growth hormone (GH) is secreted locally by normal human mammary epithelial cells upon progesterone stimulation. GH increases proliferation of a subset of cells that express growth hormone receptor (GHR) and have functional properties of stem and early progenitor cells. In 72% of ductal carcinoma in situ lesions, an expansion of the cell population that expresses GHR was observed, suggesting that GH signaling may contribute to breast cancer development.</p>},
  author       = {Lombardi, Sara and Honeth, Gabriella and Ginestier, Christophe and Shinomiya, Ireneusz and Marlow, Rebecca and Buchupalli, Bharath and Gazinska, Patrycja and Brown, John and Catchpole, Steven and Liu, Suling and Barkan, Ariel and Wicha, Max and Purushotham, Anand and Burchell, Joy and Pinder, Sarah and Dontu, Gabriela},
  issn         = {2213-6711},
  keyword      = {Cell Proliferation,Cells, Cultured,Human Growth Hormone,Humans,Mammary Glands, Human,Progesterone,Stem Cells,Journal Article,Research Support, Non-U.S. Gov't},
  language     = {eng},
  month        = {06},
  number       = {6},
  pages        = {93--780},
  publisher    = {Cell Press},
  series       = {Stem Cell Reports},
  title        = {Growth hormone is secreted by normal breast epithelium upon progesterone stimulation and increases proliferation of stem/progenitor cells},
  url          = {http://dx.doi.org/10.1016/j.stemcr.2014.05.005},
  volume       = {2},
  year         = {2014},
}