Reverse pharmacology and the de-orphanization of 7TM receptors
(2004) In Drug Discovery Today: Technologies 2(1). p.99-104- Abstract
- Approximately 800 genes coding for seven-transmembrane, G-protein-coupled receptors have so far been recognized. In spite of this, many of these receptors are defined by their sequence only, and are therefore classified as orphan receptors. Without knowing what their endogenous ligands are, we lack the information needed to understand their physiological role and hence cannot make use of them as drug targets. In this communication, we discuss different strategies, as well as difficulties in the deorphanizing process.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1129094
- author
- Kotarsky, Knut LU and Nilsson, Niclas E
- organization
- publishing date
- 2004
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Drug Discovery Today: Technologies
- volume
- 2
- issue
- 1
- pages
- 99 - 104
- publisher
- Elsevier
- external identifiers
-
- scopus:13244253657
- ISSN
- 1740-6749
- DOI
- 10.1016/j.ddtec.2004.07.003
- language
- English
- LU publication?
- yes
- id
- c5941581-3f1d-42f2-ba4a-2e153b5f921c (old id 1129094)
- date added to LUP
- 2016-04-01 15:30:28
- date last changed
- 2022-01-28 05:43:32
@article{c5941581-3f1d-42f2-ba4a-2e153b5f921c, abstract = {{Approximately 800 genes coding for seven-transmembrane, G-protein-coupled receptors have so far been recognized. In spite of this, many of these receptors are defined by their sequence only, and are therefore classified as orphan receptors. Without knowing what their endogenous ligands are, we lack the information needed to understand their physiological role and hence cannot make use of them as drug targets. In this communication, we discuss different strategies, as well as difficulties in the deorphanizing process.}}, author = {{Kotarsky, Knut and Nilsson, Niclas E}}, issn = {{1740-6749}}, language = {{eng}}, number = {{1}}, pages = {{99--104}}, publisher = {{Elsevier}}, series = {{Drug Discovery Today: Technologies}}, title = {{Reverse pharmacology and the de-orphanization of 7TM receptors}}, url = {{http://dx.doi.org/10.1016/j.ddtec.2004.07.003}}, doi = {{10.1016/j.ddtec.2004.07.003}}, volume = {{2}}, year = {{2004}}, }