Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits
(2018) In Nature Genetics 50(10). p.1412-1425- Abstract
- High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future. © 2018, The Author(s), under exclusive licence to Springer Nature America, Inc.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/c5a7d8ac-2c4e-4d51-86bd-3eed64603fc0
- author
- Evangelou, Evangelos ; Almgren, Peter LU ; Melander, Olle LU ; Elliott, Paul and Caulfield, Mark J
- author collaboration
- organization
- publishing date
- 2018
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Nature Genetics
- volume
- 50
- issue
- 10
- pages
- 14 pages
- publisher
- Nature Publishing Group
- external identifiers
-
- pmid:30224653
- scopus:85053701561
- ISSN
- 1546-1718
- DOI
- 10.1038/s41588-018-0205-x
- language
- English
- LU publication?
- yes
- additional info
- Export Date: 10 October 2018
- id
- c5a7d8ac-2c4e-4d51-86bd-3eed64603fc0
- date added to LUP
- 2018-10-10 14:14:02
- date last changed
- 2024-01-15 03:00:40
@article{c5a7d8ac-2c4e-4d51-86bd-3eed64603fc0, abstract = {{High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future. © 2018, The Author(s), under exclusive licence to Springer Nature America, Inc.}}, author = {{Evangelou, Evangelos and Almgren, Peter and Melander, Olle and Elliott, Paul and Caulfield, Mark J}}, issn = {{1546-1718}}, language = {{eng}}, number = {{10}}, pages = {{1412--1425}}, publisher = {{Nature Publishing Group}}, series = {{Nature Genetics}}, title = {{Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits}}, url = {{http://dx.doi.org/10.1038/s41588-018-0205-x}}, doi = {{10.1038/s41588-018-0205-x}}, volume = {{50}}, year = {{2018}}, }