Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

Evangelou, Evangelos ; Almgren, Peter LU ; Melander, Olle LU orcid ; Elliott, Paul and Caulfield, Mark J (2018) In Nature Genetics 50(10). p.1412-1425
Abstract
High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future. © 2018, The Author(s), under exclusive licence to Springer Nature America, Inc.
Please use this url to cite or link to this publication:
author
; ; ; and
author collaboration
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Nature Genetics
volume
50
issue
10
pages
14 pages
publisher
Nature Publishing Group
external identifiers
  • pmid:30224653
  • scopus:85053701561
ISSN
1546-1718
DOI
10.1038/s41588-018-0205-x
language
English
LU publication?
yes
additional info
Export Date: 10 October 2018
id
c5a7d8ac-2c4e-4d51-86bd-3eed64603fc0
date added to LUP
2018-10-10 14:14:02
date last changed
2024-01-15 03:00:40
@article{c5a7d8ac-2c4e-4d51-86bd-3eed64603fc0,
  abstract     = {{High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future. © 2018, The Author(s), under exclusive licence to Springer Nature America, Inc.}},
  author       = {{Evangelou, Evangelos and Almgren, Peter and Melander, Olle and Elliott, Paul and Caulfield, Mark J}},
  issn         = {{1546-1718}},
  language     = {{eng}},
  number       = {{10}},
  pages        = {{1412--1425}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Nature Genetics}},
  title        = {{Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits}},
  url          = {{http://dx.doi.org/10.1038/s41588-018-0205-x}},
  doi          = {{10.1038/s41588-018-0205-x}},
  volume       = {{50}},
  year         = {{2018}},
}