Clinical Outcomes and Follow-Up in Children With Prenatally Detected Unilateral Ureteropelvic Junction Obstruction
Malmström, Tim LU ; Bekassy, Zivile LU ; Salö, Martin LU ; Tjernberg, Anna Röckert and Stenström, Pernilla LU
(2025)
In Acta Paediatrica, International Journal of Paediatrics
114(8).
p.2066-2072
- Abstract
Aim: To explore the possibility of reducing the diagnostic burden in children with prenatally detected unilateral ureteropelvic junction obstruction. Methods: Children with unilateral ureteropelvic junction obstruction (2012–2020) were identified from a prenatal hydronephrosis registry. The frequency of adverse events, predictors for event-free follow-up beyond 1 year of age, and examination burden in children with conservatively managed unilateral ureteropelvic junction obstruction were assessed. Adverse events included febrile urinary tract infections, > 10% decline in differential renal function, or both, leading to surgery. Follow-up ended at clinical conclusion or surgical decision. Results: Forty-seven children were included,... (More)
Aim: To explore the possibility of reducing the diagnostic burden in children with prenatally detected unilateral ureteropelvic junction obstruction. Methods: Children with unilateral ureteropelvic junction obstruction (2012–2020) were identified from a prenatal hydronephrosis registry. The frequency of adverse events, predictors for event-free follow-up beyond 1 year of age, and examination burden in children with conservatively managed unilateral ureteropelvic junction obstruction were assessed. Adverse events included febrile urinary tract infections, > 10% decline in differential renal function, or both, leading to surgery. Follow-up ended at clinical conclusion or surgical decision. Results: Forty-seven children were included, with a follow-up of median 22.5 (2–115, min-max) months. Overall, 43% (20/47) had no adverse events. Adverse events occurred within 2 years in 85% (23/27). Predictors of event-free follow-up beyond 1 year were a postnatal anteroposterior diameter < 15 mm at 12 months (p < 0.001) or a stable anteroposterior diameter during the first year (p = 0.04). Patients without adverse events underwent a median of eight (3–26, min–max) diagnostic imaging examinations. Conclusions: In children with antenatally detected ureteropelvic junction obstruction, 43% had no adverse events, but a substantial examination burden. Predictors of a non-eventful trace, useful in guidelines, were a postnatal anteroposterior diameter < 15 mm or stable at 12 months.
(Less)
- author
- Malmström, Tim
LU
; Bekassy, Zivile
LU
; Salö, Martin
LU
; Tjernberg, Anna Röckert
and Stenström, Pernilla
LU
- organization
- publishing date
- 2025
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- examinations, hydronephrosis, management, obstruction, ureteropelvic junction
- in
- Acta Paediatrica, International Journal of Paediatrics
- volume
- 114
- issue
- 8
- pages
- 7 pages
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:40192470
- scopus:105002124417
- ISSN
- 0803-5253
- DOI
- 10.1111/apa.70086
- language
- English
- LU publication?
- yes
- id
- c5b64451-1e8a-48dd-afd4-1471bce33d61
- date added to LUP
- 2025-09-01 13:52:26
- date last changed
- 2025-09-29 16:49:19
@article{c5b64451-1e8a-48dd-afd4-1471bce33d61,
abstract = {{<p>Aim: To explore the possibility of reducing the diagnostic burden in children with prenatally detected unilateral ureteropelvic junction obstruction. Methods: Children with unilateral ureteropelvic junction obstruction (2012–2020) were identified from a prenatal hydronephrosis registry. The frequency of adverse events, predictors for event-free follow-up beyond 1 year of age, and examination burden in children with conservatively managed unilateral ureteropelvic junction obstruction were assessed. Adverse events included febrile urinary tract infections, > 10% decline in differential renal function, or both, leading to surgery. Follow-up ended at clinical conclusion or surgical decision. Results: Forty-seven children were included, with a follow-up of median 22.5 (2–115, min-max) months. Overall, 43% (20/47) had no adverse events. Adverse events occurred within 2 years in 85% (23/27). Predictors of event-free follow-up beyond 1 year were a postnatal anteroposterior diameter < 15 mm at 12 months (p < 0.001) or a stable anteroposterior diameter during the first year (p = 0.04). Patients without adverse events underwent a median of eight (3–26, min–max) diagnostic imaging examinations. Conclusions: In children with antenatally detected ureteropelvic junction obstruction, 43% had no adverse events, but a substantial examination burden. Predictors of a non-eventful trace, useful in guidelines, were a postnatal anteroposterior diameter < 15 mm or stable at 12 months.</p>}},
author = {{Malmström, Tim and Bekassy, Zivile and Salö, Martin and Tjernberg, Anna Röckert and Stenström, Pernilla}},
issn = {{0803-5253}},
keywords = {{examinations; hydronephrosis; management; obstruction; ureteropelvic junction}},
language = {{eng}},
number = {{8}},
pages = {{2066--2072}},
publisher = {{Wiley-Blackwell}},
series = {{Acta Paediatrica, International Journal of Paediatrics}},
title = {{Clinical Outcomes and Follow-Up in Children With Prenatally Detected Unilateral Ureteropelvic Junction Obstruction}},
url = {{http://dx.doi.org/10.1111/apa.70086}},
doi = {{10.1111/apa.70086}},
volume = {{114}},
year = {{2025}},
}