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Influence of nanomechanical stress induced by ZnO nanoparticles of different shapes on the viability of cells

Matuła, Kinga; Richter, Łukasz; Adamkiewicz, Witold; Åkerström, Bo LU ; Paczesny, Jan and Hołyst, Robert (2016) In Soft Matter 12(18). p.4162-4169
Abstract

There is growing interest in nanostructures interacting with living organisms. However, there are still no general rules for the design of biocompatible nanodevices. Here, we present a step towards understanding the interactions between nanostructures and living cells. We study the influence of nanomechanical stress induced by zinc oxide (ZnO) nanostructures of different shapes on the viability of both prokaryotic (Gram-negative bacteria: Escherichia coli and Enterobacter aerogenes, and Gram-positive bacteria: Staphylococcus epidermidis and Corynebacterium glutamicum) and eukaryotic cells (yeast Saccharomyces cerevisiae and liver cancer cell line HepG2). Nanoparticles (NPs) and nanorods (NRs) of matching crystallographic... (More)

There is growing interest in nanostructures interacting with living organisms. However, there are still no general rules for the design of biocompatible nanodevices. Here, we present a step towards understanding the interactions between nanostructures and living cells. We study the influence of nanomechanical stress induced by zinc oxide (ZnO) nanostructures of different shapes on the viability of both prokaryotic (Gram-negative bacteria: Escherichia coli and Enterobacter aerogenes, and Gram-positive bacteria: Staphylococcus epidermidis and Corynebacterium glutamicum) and eukaryotic cells (yeast Saccharomyces cerevisiae and liver cancer cell line HepG2). Nanoparticles (NPs) and nanorods (NRs) of matching crystallographic structure (P63mc) and active surface area (in the order of 5 × 10-2 μm2) are almost non-toxic for cells under static conditions. However, under conditions that enable collisions between ZnO nanostructures and cells, NRs appear to be more damaging compared to NPs. This is due to the increased probability of mechanical damage caused by nanorods upon puncturing of the cell wall and membranes. Gram-positive bacteria, which have thicker cell walls, are more resistant to nanomechanical stress induced by NRs compared to Gram-negative strains and eukaryotic cells. The presented results may be exploited to improve the properties of nanotechnology based products such as implants, drug delivery systems, antibacterial emulsions and cosmetics.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Soft Matter
volume
12
issue
18
pages
8 pages
publisher
Royal Society of Chemistry
external identifiers
  • scopus:84968741456
  • wos:000375800500011
ISSN
1744-683X
DOI
10.1039/c6sm00336b
language
English
LU publication?
yes
id
c5bce8f5-84d6-4f54-b39e-6c8b76bcfe6b
date added to LUP
2017-02-22 13:08:24
date last changed
2017-09-18 11:34:27
@article{c5bce8f5-84d6-4f54-b39e-6c8b76bcfe6b,
  abstract     = {<p>There is growing interest in nanostructures interacting with living organisms. However, there are still no general rules for the design of biocompatible nanodevices. Here, we present a step towards understanding the interactions between nanostructures and living cells. We study the influence of nanomechanical stress induced by zinc oxide (ZnO) nanostructures of different shapes on the viability of both prokaryotic (Gram-negative bacteria: Escherichia coli and Enterobacter aerogenes, and Gram-positive bacteria: Staphylococcus epidermidis and Corynebacterium glutamicum) and eukaryotic cells (yeast Saccharomyces cerevisiae and liver cancer cell line HepG<sub>2</sub>). Nanoparticles (NPs) and nanorods (NRs) of matching crystallographic structure (P6<sub>3</sub>mc) and active surface area (in the order of 5 × 10<sup>-2</sup> μm<sup>2</sup>) are almost non-toxic for cells under static conditions. However, under conditions that enable collisions between ZnO nanostructures and cells, NRs appear to be more damaging compared to NPs. This is due to the increased probability of mechanical damage caused by nanorods upon puncturing of the cell wall and membranes. Gram-positive bacteria, which have thicker cell walls, are more resistant to nanomechanical stress induced by NRs compared to Gram-negative strains and eukaryotic cells. The presented results may be exploited to improve the properties of nanotechnology based products such as implants, drug delivery systems, antibacterial emulsions and cosmetics.</p>},
  author       = {Matuła, Kinga and Richter, Łukasz and Adamkiewicz, Witold and Åkerström, Bo and Paczesny, Jan and Hołyst, Robert},
  issn         = {1744-683X},
  language     = {eng},
  number       = {18},
  pages        = {4162--4169},
  publisher    = {Royal Society of Chemistry},
  series       = {Soft Matter},
  title        = {Influence of nanomechanical stress induced by ZnO nanoparticles of different shapes on the viability of cells},
  url          = {http://dx.doi.org/10.1039/c6sm00336b},
  volume       = {12},
  year         = {2016},
}