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Molecular basis of cell-biomaterial interaction: Insights gained from transcriptomic and proteomic studies

Gallagher, William M.; Lynch, Iseult LU ; Allen, Lorcan T.; Miller, Ian; Penney, Stephen C.; O'Connor, Darran P.; Pennington, Stephen; Keenan, Alan K. and Dawson, Kenneth A. (2006) In Biomaterials 27(35). p.5871-5882
Abstract
With the growing interest in clinical interventions that involve medical devices, the role for new biomaterials in modern medicine is currently expanding at a phenomenal rate. Failure of most implant materials stems from an inability to predict and control biological phenomena, such as protein adsorption and cell interaction, resulting in an inappropriate host response to the materials. Contemporary advances in biological investigation are starting to shift focus in the biomaterials field, in particular with the advent of high-throughput methodologies for gene and protein expression profiling. Here, we examine the role that emerging transcriptomic and proteomic technologies could play in relation to biomaterial development and usage.... (More)
With the growing interest in clinical interventions that involve medical devices, the role for new biomaterials in modern medicine is currently expanding at a phenomenal rate. Failure of most implant materials stems from an inability to predict and control biological phenomena, such as protein adsorption and cell interaction, resulting in an inappropriate host response to the materials. Contemporary advances in biological investigation are starting to shift focus in the biomaterials field, in particular with the advent of high-throughput methodologies for gene and protein expression profiling. Here, we examine the role that emerging transcriptomic and proteomic technologies could play in relation to biomaterial development and usage. Moreover, a number of studies are highlighted which have utilized such approaches in order to try to create a deeper understanding of cell-biomaterial interactions and, hence, improve our ability to predict and control the biocompatibility of new materials. (c) 2006 Elsevier Ltd. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
mass, proteomics, DNA microarrays, biocompatibility, transcriptomics, cell interaction, spectrometry
in
Biomaterials
volume
27
issue
35
pages
5871 - 5882
publisher
Elsevier
external identifiers
  • wos:000241633500001
  • scopus:33748305553
ISSN
1878-5905
DOI
10.1016/j.biomaterials.2006.07.040
language
English
LU publication?
yes
id
c5e65cbc-9804-4b89-9597-7d9046b26418 (old id 384216)
date added to LUP
2007-10-03 08:10:48
date last changed
2019-07-30 01:53:34
@article{c5e65cbc-9804-4b89-9597-7d9046b26418,
  abstract     = {With the growing interest in clinical interventions that involve medical devices, the role for new biomaterials in modern medicine is currently expanding at a phenomenal rate. Failure of most implant materials stems from an inability to predict and control biological phenomena, such as protein adsorption and cell interaction, resulting in an inappropriate host response to the materials. Contemporary advances in biological investigation are starting to shift focus in the biomaterials field, in particular with the advent of high-throughput methodologies for gene and protein expression profiling. Here, we examine the role that emerging transcriptomic and proteomic technologies could play in relation to biomaterial development and usage. Moreover, a number of studies are highlighted which have utilized such approaches in order to try to create a deeper understanding of cell-biomaterial interactions and, hence, improve our ability to predict and control the biocompatibility of new materials. (c) 2006 Elsevier Ltd. All rights reserved.},
  author       = {Gallagher, William M. and Lynch, Iseult and Allen, Lorcan T. and Miller, Ian and Penney, Stephen C. and O'Connor, Darran P. and Pennington, Stephen and Keenan, Alan K. and Dawson, Kenneth A.},
  issn         = {1878-5905},
  keyword      = {mass,proteomics,DNA microarrays,biocompatibility,transcriptomics,cell interaction,spectrometry},
  language     = {eng},
  number       = {35},
  pages        = {5871--5882},
  publisher    = {Elsevier},
  series       = {Biomaterials},
  title        = {Molecular basis of cell-biomaterial interaction: Insights gained from transcriptomic and proteomic studies},
  url          = {http://dx.doi.org/10.1016/j.biomaterials.2006.07.040},
  volume       = {27},
  year         = {2006},
}