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Long-term effects on the incidence of second primary cancers in a randomized trial of two and five years of adjuvant tamoxifen

Rosell, Johan; Nordenskjöld, Bo; Bengtsson, Nils-Olof; Fornander, Tommy; Hatschek, Thomas; Lindman, Henrik; Malmström, Per Olof LU ; Wallgren, Arne; Stål, Olle and Carstensen, John (2017) In Acta Oncologica 56(4). p.614-617
Abstract

Background: Tamoxifen is a well established treatment for breast cancer, but its long-term effects on the incidence of secondary cancers are not fully evaluated. Material and methods: We have studied 4128 postmenopausal patients with early stage breast cancer who were alive and free of breast cancer recurrence after two years of tamoxifen, and who were randomized to receive totally two or five years of therapy. Results: Compared to patients randomized to two years of tamoxifen the incidence of contralateral breast cancer [hazard ratio (HR) 0.73; 95% CI 0.56–0.96] and of lung cancer (HR 0.45; 95% CI 0.27–0.77), especially squamous cell and small cell lung cancer, were reduced in the five-year group, and similar results were seen when... (More)

Background: Tamoxifen is a well established treatment for breast cancer, but its long-term effects on the incidence of secondary cancers are not fully evaluated. Material and methods: We have studied 4128 postmenopausal patients with early stage breast cancer who were alive and free of breast cancer recurrence after two years of tamoxifen, and who were randomized to receive totally two or five years of therapy. Results: Compared to patients randomized to two years of tamoxifen the incidence of contralateral breast cancer [hazard ratio (HR) 0.73; 95% CI 0.56–0.96] and of lung cancer (HR 0.45; 95% CI 0.27–0.77), especially squamous cell and small cell lung cancer, were reduced in the five-year group, and similar results were seen when restricting the analysis to the 10-year period after treatment stopped. An increased incidence of endometrial cancer was observed in the five-year group, but the excess risk decreased over time. Conclusion: Further studies of the effects of tamoxifen on the risk of different histological types of lung cancer are needed.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Oncologica
volume
56
issue
4
pages
4 pages
publisher
Taylor & Francis
external identifiers
  • scopus:85009232025
  • wos:000399499600016
ISSN
0284-186X
DOI
10.1080/0284186X.2016.1273547
language
English
LU publication?
yes
id
c5e83e07-66cc-40c0-90e4-25b5e7ffa0fb
date added to LUP
2017-02-10 14:06:15
date last changed
2018-01-07 11:49:15
@article{c5e83e07-66cc-40c0-90e4-25b5e7ffa0fb,
  abstract     = {<p>Background: Tamoxifen is a well established treatment for breast cancer, but its long-term effects on the incidence of secondary cancers are not fully evaluated. Material and methods: We have studied 4128 postmenopausal patients with early stage breast cancer who were alive and free of breast cancer recurrence after two years of tamoxifen, and who were randomized to receive totally two or five years of therapy. Results: Compared to patients randomized to two years of tamoxifen the incidence of contralateral breast cancer [hazard ratio (HR) 0.73; 95% CI 0.56–0.96] and of lung cancer (HR 0.45; 95% CI 0.27–0.77), especially squamous cell and small cell lung cancer, were reduced in the five-year group, and similar results were seen when restricting the analysis to the 10-year period after treatment stopped. An increased incidence of endometrial cancer was observed in the five-year group, but the excess risk decreased over time. Conclusion: Further studies of the effects of tamoxifen on the risk of different histological types of lung cancer are needed.</p>},
  author       = {Rosell, Johan and Nordenskjöld, Bo and Bengtsson, Nils-Olof and Fornander, Tommy and Hatschek, Thomas and Lindman, Henrik and Malmström, Per Olof and Wallgren, Arne and Stål, Olle and Carstensen, John},
  issn         = {0284-186X},
  language     = {eng},
  month        = {01},
  number       = {4},
  pages        = {614--617},
  publisher    = {Taylor & Francis},
  series       = {Acta Oncologica},
  title        = {Long-term effects on the incidence of second primary cancers in a randomized trial of two and five years of adjuvant tamoxifen},
  url          = {http://dx.doi.org/10.1080/0284186X.2016.1273547},
  volume       = {56},
  year         = {2017},
}