Advanced

Pericytes limit tumor cell metastasis.

Xian, Xiaojie LU ; Hakansson, Joakim; Ståhlberg, Anders; Lindblom, Per; Betsholtz, Christer; Gerhardt, Holger and Semb, Henrik LU (2006) In Journal of Clinical Investigation 116(3). p.642-651
Abstract
Previously we observed that neural cell adhesion molecule (NCAM) deficiency in P tumor cells facilitates metastasis into distant organs and local lymph nodes. Here, we show that NCAM-deficient P cell tumors grew leaky blood vessels with perturbed pericyte-endothelial cell-cell interactions and deficient perivascular deposition of ECM components. Conversely, tumor cell expression of NCAM in a fibrosarcoma model (T241) improved pericyte recruitment and increased perivascular deposition of ECM molecules. Together, these findings suggest that NCAM may limit tumor cell metastasis by stabilizing the microvessel wall. To directly address whether pericyte dysfunction increases the metastatic potential of solid tumors, we studied P cell... (More)
Previously we observed that neural cell adhesion molecule (NCAM) deficiency in P tumor cells facilitates metastasis into distant organs and local lymph nodes. Here, we show that NCAM-deficient P cell tumors grew leaky blood vessels with perturbed pericyte-endothelial cell-cell interactions and deficient perivascular deposition of ECM components. Conversely, tumor cell expression of NCAM in a fibrosarcoma model (T241) improved pericyte recruitment and increased perivascular deposition of ECM molecules. Together, these findings suggest that NCAM may limit tumor cell metastasis by stabilizing the microvessel wall. To directly address whether pericyte dysfunction increases the metastatic potential of solid tumors, we studied P cell tumorigenesis in primary pericyte-deficient Pdgfb(ret/ret) mice. This resulted in beta tumor cell metastases in distant organs and local lymph nodes, demonstrating a role for pericytes in limiting tumor cell metastasis. These data support a new model for how tumor cells trigger metastasis by perturbing pericyte-endothelial cell-cell interactions. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Clinical Investigation
volume
116
issue
3
pages
642 - 651
publisher
Am Soc Clin Investig
external identifiers
  • wos:000235854300015
  • pmid:16470244
  • scopus:33644643376
ISSN
0021-9738
DOI
10.1172/JCI25705
language
English
LU publication?
yes
id
c5fc7ff6-3935-4242-aa2e-3471a51fd50a (old id 153560)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16470244&dopt=Abstract
date added to LUP
2007-07-24 09:51:00
date last changed
2019-10-13 04:12:29
@article{c5fc7ff6-3935-4242-aa2e-3471a51fd50a,
  abstract     = {Previously we observed that neural cell adhesion molecule (NCAM) deficiency in P tumor cells facilitates metastasis into distant organs and local lymph nodes. Here, we show that NCAM-deficient P cell tumors grew leaky blood vessels with perturbed pericyte-endothelial cell-cell interactions and deficient perivascular deposition of ECM components. Conversely, tumor cell expression of NCAM in a fibrosarcoma model (T241) improved pericyte recruitment and increased perivascular deposition of ECM molecules. Together, these findings suggest that NCAM may limit tumor cell metastasis by stabilizing the microvessel wall. To directly address whether pericyte dysfunction increases the metastatic potential of solid tumors, we studied P cell tumorigenesis in primary pericyte-deficient Pdgfb(ret/ret) mice. This resulted in beta tumor cell metastases in distant organs and local lymph nodes, demonstrating a role for pericytes in limiting tumor cell metastasis. These data support a new model for how tumor cells trigger metastasis by perturbing pericyte-endothelial cell-cell interactions.},
  author       = {Xian, Xiaojie and Hakansson, Joakim and Ståhlberg, Anders and Lindblom, Per and Betsholtz, Christer and Gerhardt, Holger and Semb, Henrik},
  issn         = {0021-9738},
  language     = {eng},
  number       = {3},
  pages        = {642--651},
  publisher    = {Am Soc Clin Investig},
  series       = {Journal of Clinical Investigation},
  title        = {Pericytes limit tumor cell metastasis.},
  url          = {http://dx.doi.org/10.1172/JCI25705},
  volume       = {116},
  year         = {2006},
}