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Biphasic blood pressure response to neuropeptide Y in anesthetized rats

Grundemar, L LU ; Wahlestedt, C ; Shen, G H ; Zukowska-Grojec, Z and Håkanson, R LU (1990) In European Journal of Pharmacology 179(1-2). p.83-87
Abstract

The effects of neuropeptide Y (NPY) on systemic arterial blood pressure and heart rate were studied in anesthetized intact and pithed rats. I.v. doses of NPY (0.3-30 nmol/kg) raised the mean arterial blood pressure dose dependently. At doses of greater than or equal to 3.0 nmol/kg, the initial pressor response was followed by a dose-dependent fall in blood pressure in intact and pithed rats. The depressor response was accompanied 1-2 min after the NPY injection by a slight increase in heart rate in pithed rats but not in intact rats, and 10 min after the injection by a decrease in heart rate in intact rats. After repeated injections of NPY, the depressor effect vanished, whereas the integrated pressor response over time was markedly... (More)

The effects of neuropeptide Y (NPY) on systemic arterial blood pressure and heart rate were studied in anesthetized intact and pithed rats. I.v. doses of NPY (0.3-30 nmol/kg) raised the mean arterial blood pressure dose dependently. At doses of greater than or equal to 3.0 nmol/kg, the initial pressor response was followed by a dose-dependent fall in blood pressure in intact and pithed rats. The depressor response was accompanied 1-2 min after the NPY injection by a slight increase in heart rate in pithed rats but not in intact rats, and 10 min after the injection by a decrease in heart rate in intact rats. After repeated injections of NPY, the depressor effect vanished, whereas the integrated pressor response over time was markedly enhanced. After pretreatment with the histamine H1-receptor antagonist, mepyramine, or with the histamine liberator, compound 48/80, the pressor response to NPY remained but the depressor response disappeared. We suggest that the marked fall in blood pressure can be attributed to NPY-evoked histamine release from mast cells.

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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Anesthesia, Animals, Blood Pressure/drug effects, Decerebrate State, Heart Rate/drug effects, Injections, Intravenous, Male, Neuropeptide Y/administration & dosage, Pyrilamine/pharmacology, Rats, Rats, Inbred Strains
in
European Journal of Pharmacology
volume
179
issue
1-2
pages
83 - 87
publisher
Elsevier
external identifiers
  • scopus:0025325999
  • pmid:2364989
ISSN
0014-2999
DOI
10.1016/0014-2999(90)90404-t
language
English
LU publication?
yes
id
c60a2c51-40b7-4c10-b925-3323a09b4a81
date added to LUP
2019-09-03 14:13:08
date last changed
2024-01-01 18:56:55
@article{c60a2c51-40b7-4c10-b925-3323a09b4a81,
  abstract     = {{<p>The effects of neuropeptide Y (NPY) on systemic arterial blood pressure and heart rate were studied in anesthetized intact and pithed rats. I.v. doses of NPY (0.3-30 nmol/kg) raised the mean arterial blood pressure dose dependently. At doses of greater than or equal to 3.0 nmol/kg, the initial pressor response was followed by a dose-dependent fall in blood pressure in intact and pithed rats. The depressor response was accompanied 1-2 min after the NPY injection by a slight increase in heart rate in pithed rats but not in intact rats, and 10 min after the injection by a decrease in heart rate in intact rats. After repeated injections of NPY, the depressor effect vanished, whereas the integrated pressor response over time was markedly enhanced. After pretreatment with the histamine H1-receptor antagonist, mepyramine, or with the histamine liberator, compound 48/80, the pressor response to NPY remained but the depressor response disappeared. We suggest that the marked fall in blood pressure can be attributed to NPY-evoked histamine release from mast cells.</p>}},
  author       = {{Grundemar, L and Wahlestedt, C and Shen, G H and Zukowska-Grojec, Z and Håkanson, R}},
  issn         = {{0014-2999}},
  keywords     = {{Anesthesia; Animals; Blood Pressure/drug effects; Decerebrate State; Heart Rate/drug effects; Injections, Intravenous; Male; Neuropeptide Y/administration & dosage; Pyrilamine/pharmacology; Rats; Rats, Inbred Strains}},
  language     = {{eng}},
  month        = {{04}},
  number       = {{1-2}},
  pages        = {{83--87}},
  publisher    = {{Elsevier}},
  series       = {{European Journal of Pharmacology}},
  title        = {{Biphasic blood pressure response to neuropeptide Y in anesthetized rats}},
  url          = {{http://dx.doi.org/10.1016/0014-2999(90)90404-t}},
  doi          = {{10.1016/0014-2999(90)90404-t}},
  volume       = {{179}},
  year         = {{1990}},
}