Associations of depressive symptoms and cortisol with cognitive performance among memory clinic patients
(2025) In International Psychogeriatrics 37(2).- Abstract
OBJECTIVE: Test the hypothesis that depressive symptoms are associated with cognitive performance and that cortisol levels may explain this association independently of Alzheimer's Disease (AD) biomarker levels.
DESIGN: Longitudinal observational study.
SETTING: Memory clinic, Karolinska University Hospital, Stockholm, Sweden.
PARTICIPANTS: Consecutive patients (n = 162) who agreed to take part in the Cortisol and Stress in AD (Co-STAR) study during 2014-2017 and had data available for variables of interest.
MEASUREMENTS: Participants rated their depressive symptoms using the Geriatric Depression Scale (GDS) and collected diurnal salivary cortisol samples at home. Cognitive performance was assessed by... (More)
OBJECTIVE: Test the hypothesis that depressive symptoms are associated with cognitive performance and that cortisol levels may explain this association independently of Alzheimer's Disease (AD) biomarker levels.
DESIGN: Longitudinal observational study.
SETTING: Memory clinic, Karolinska University Hospital, Stockholm, Sweden.
PARTICIPANTS: Consecutive patients (n = 162) who agreed to take part in the Cortisol and Stress in AD (Co-STAR) study during 2014-2017 and had data available for variables of interest.
MEASUREMENTS: Participants rated their depressive symptoms using the Geriatric Depression Scale (GDS) and collected diurnal salivary cortisol samples at home. Cognitive performance was assessed by standardized cognitive tests in the following domains: memory, working memory, processing speed, perceptual reasoning, and general cognitive function. Dementia, mild cognitive impairment (MCI), and subjective cognitive decline (SCD) were diagnosed as part of the clinical work-up. We determined the associations between GDS and cognitive domain scores using linear regressions, including cortisol levels as covariates. We also tested if cerebrospinal fluid (CSF) AD biomarkers amyloid β42 (Aβ42) and tau proteins modified these associations.
RESULTS: The GDS score was negatively associated with performance in working memory and processing speed, independently of cortisol levels. These associations were no longer significant after introducing AD biomarkers as covariates. Baseline GDS score was not associated with change in memory or processing speed at follow-up.
CONCLUSIONS: The underlying amyloid pathology may affect the association between depressive symptoms and cognitive performance in memory clinic patients.
(Less)
- author
- organization
- publishing date
- 2025-03
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Humans, Hydrocortisone/analysis, Male, Female, Aged, Depression/diagnosis, Cognitive Dysfunction/diagnosis, Longitudinal Studies, Biomarkers, Sweden/epidemiology, Saliva/chemistry, Neuropsychological Tests, Alzheimer Disease/diagnosis, Cognition/physiology, Amyloid beta-Peptides/cerebrospinal fluid, Aged, 80 and over, tau Proteins/cerebrospinal fluid, Middle Aged, Memory, Short-Term/physiology
- in
- International Psychogeriatrics
- volume
- 37
- issue
- 2
- article number
- 100009
- publisher
- Cambridge University Press
- external identifiers
-
- pmid:40086903
- scopus:105000486897
- ISSN
- 1741-203X
- DOI
- 10.1016/j.inpsyc.2024.100009
- language
- English
- LU publication?
- yes
- additional info
- Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.
- id
- c634af0b-d02a-435a-87bb-54f0e776e090
- date added to LUP
- 2025-03-20 09:06:54
- date last changed
- 2025-07-14 07:56:00
@article{c634af0b-d02a-435a-87bb-54f0e776e090,
abstract = {{<p>OBJECTIVE: Test the hypothesis that depressive symptoms are associated with cognitive performance and that cortisol levels may explain this association independently of Alzheimer's Disease (AD) biomarker levels.</p><p>DESIGN: Longitudinal observational study.</p><p>SETTING: Memory clinic, Karolinska University Hospital, Stockholm, Sweden.</p><p>PARTICIPANTS: Consecutive patients (n = 162) who agreed to take part in the Cortisol and Stress in AD (Co-STAR) study during 2014-2017 and had data available for variables of interest.</p><p>MEASUREMENTS: Participants rated their depressive symptoms using the Geriatric Depression Scale (GDS) and collected diurnal salivary cortisol samples at home. Cognitive performance was assessed by standardized cognitive tests in the following domains: memory, working memory, processing speed, perceptual reasoning, and general cognitive function. Dementia, mild cognitive impairment (MCI), and subjective cognitive decline (SCD) were diagnosed as part of the clinical work-up. We determined the associations between GDS and cognitive domain scores using linear regressions, including cortisol levels as covariates. We also tested if cerebrospinal fluid (CSF) AD biomarkers amyloid β42 (Aβ42) and tau proteins modified these associations.</p><p>RESULTS: The GDS score was negatively associated with performance in working memory and processing speed, independently of cortisol levels. These associations were no longer significant after introducing AD biomarkers as covariates. Baseline GDS score was not associated with change in memory or processing speed at follow-up.</p><p>CONCLUSIONS: The underlying amyloid pathology may affect the association between depressive symptoms and cognitive performance in memory clinic patients.</p>}},
author = {{Olusegun Adedeji, Dickson and Holleman, Jasper and Johansson, Lena and Kåreholt, Ingemar and Aspö, Malin and Hagman, Göran and Akenine, Ulrika and Overton, Marieclaire and Solomon, Alina and Kivipelto, Miia and Sindi, Shireen and Sacuiu, Simona F}},
issn = {{1741-203X}},
keywords = {{Humans; Hydrocortisone/analysis; Male; Female; Aged; Depression/diagnosis; Cognitive Dysfunction/diagnosis; Longitudinal Studies; Biomarkers; Sweden/epidemiology; Saliva/chemistry; Neuropsychological Tests; Alzheimer Disease/diagnosis; Cognition/physiology; Amyloid beta-Peptides/cerebrospinal fluid; Aged, 80 and over; tau Proteins/cerebrospinal fluid; Middle Aged; Memory, Short-Term/physiology}},
language = {{eng}},
number = {{2}},
publisher = {{Cambridge University Press}},
series = {{International Psychogeriatrics}},
title = {{Associations of depressive symptoms and cortisol with cognitive performance among memory clinic patients}},
url = {{http://dx.doi.org/10.1016/j.inpsyc.2024.100009}},
doi = {{10.1016/j.inpsyc.2024.100009}},
volume = {{37}},
year = {{2025}},
}