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Spectral Changes of EEG Following a 6-Week Low-Dose Oral Ketamine Treatment in Adults With Major Depressive Disorder and Chronic Suicidality

Anijärv, T E LU ; Can, A T ; Gallay, C C ; Forsyth, G A ; Dutton, M ; Mitchell, J S ; Hermens, D F and Lagopoulos, J (2023) In International Journal of Neuropsychopharmacology 26(4). p.259-267
Abstract

BACKGROUND: Ketamine has considerable therapeutic potential in alleviating major depressive disorder and chronic suicidality. However, the clinical diagnosis of neuropsychiatric disorders requires more robust diagnostic criteria. Electroencephalography (EEG) has shown promise in classifying depressive and suicidal patients from healthy individuals. The present study aimed to identify changes in the spectral properties of EEG in patients with major depressive disorder and chronic suicidality after completing the 6-week Oral Ketamine Trial on Suicidality with follow-up occurring 4 weeks after final ketamine treatment and determine associations between EEG spectral output and clinical symptoms.

METHODS: Participants (n = 25) had... (More)

BACKGROUND: Ketamine has considerable therapeutic potential in alleviating major depressive disorder and chronic suicidality. However, the clinical diagnosis of neuropsychiatric disorders requires more robust diagnostic criteria. Electroencephalography (EEG) has shown promise in classifying depressive and suicidal patients from healthy individuals. The present study aimed to identify changes in the spectral properties of EEG in patients with major depressive disorder and chronic suicidality after completing the 6-week Oral Ketamine Trial on Suicidality with follow-up occurring 4 weeks after final ketamine treatment and determine associations between EEG spectral output and clinical symptoms.

METHODS: Participants (n = 25) had 4-minute eyes closed resting state EEG recorded at frontal, temporal, centro-parietal, and occipital regions. Spectral analysis was performed with Welch's power spectrum density method, and the power of 4 distinct frequency bands was analyzed: theta, alpha, low-beta, and high-beta. Correlation analyses between changes in clinical symptoms and spectral power were conducted using Spearman's ranked correlation.

RESULTS: Between pre- and posttreatment, only centro-parietal alpha power decreased. Between posttreatment and follow-up, centro-parietal alpha increased again in addition to increases in temporal alpha, centro-parietal and temporal theta, and occipital low-beta and decreases in occipital theta and temporal low-beta. Additionally, the decrease of occipital theta positively correlated with clinical subscales for depression and stress.

CONCLUSIONS: EEG spectral analysis revealed significant changes in theta, alpha, and low-beta frequency bands. Alpha band showed initial changes after treatment; however, this trended back toward baseline levels after the treatment cessation. In contrast, theta and low-beta showed significant power changes only after the treatment had ended.

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Please use this url to cite or link to this publication:
author
; ; ; ; ; ; and
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Adult, Humans, Depressive Disorder, Major/drug therapy, Electroencephalography/methods, Ketamine/therapeutic use, Suicidal Ideation, Suicide
in
International Journal of Neuropsychopharmacology
volume
26
issue
4
pages
259 - 267
publisher
Cambridge University Press
external identifiers
  • scopus:85152616068
  • pmid:36789509
ISSN
1469-5111
DOI
10.1093/ijnp/pyad006
language
English
LU publication?
no
additional info
© The Author(s) 2023. Published by Oxford University Press on behalf of CINP.
id
c6436ccb-6840-4cf2-b486-8ed9bafffe1d
date added to LUP
2024-02-01 10:20:45
date last changed
2024-04-18 14:34:12
@article{c6436ccb-6840-4cf2-b486-8ed9bafffe1d,
  abstract     = {{<p>BACKGROUND: Ketamine has considerable therapeutic potential in alleviating major depressive disorder and chronic suicidality. However, the clinical diagnosis of neuropsychiatric disorders requires more robust diagnostic criteria. Electroencephalography (EEG) has shown promise in classifying depressive and suicidal patients from healthy individuals. The present study aimed to identify changes in the spectral properties of EEG in patients with major depressive disorder and chronic suicidality after completing the 6-week Oral Ketamine Trial on Suicidality with follow-up occurring 4 weeks after final ketamine treatment and determine associations between EEG spectral output and clinical symptoms.</p><p>METHODS: Participants (n = 25) had 4-minute eyes closed resting state EEG recorded at frontal, temporal, centro-parietal, and occipital regions. Spectral analysis was performed with Welch's power spectrum density method, and the power of 4 distinct frequency bands was analyzed: theta, alpha, low-beta, and high-beta. Correlation analyses between changes in clinical symptoms and spectral power were conducted using Spearman's ranked correlation.</p><p>RESULTS: Between pre- and posttreatment, only centro-parietal alpha power decreased. Between posttreatment and follow-up, centro-parietal alpha increased again in addition to increases in temporal alpha, centro-parietal and temporal theta, and occipital low-beta and decreases in occipital theta and temporal low-beta. Additionally, the decrease of occipital theta positively correlated with clinical subscales for depression and stress.</p><p>CONCLUSIONS: EEG spectral analysis revealed significant changes in theta, alpha, and low-beta frequency bands. Alpha band showed initial changes after treatment; however, this trended back toward baseline levels after the treatment cessation. In contrast, theta and low-beta showed significant power changes only after the treatment had ended.</p>}},
  author       = {{Anijärv, T E and Can, A T and Gallay, C C and Forsyth, G A and Dutton, M and Mitchell, J S and Hermens, D F and Lagopoulos, J}},
  issn         = {{1469-5111}},
  keywords     = {{Adult; Humans; Depressive Disorder, Major/drug therapy; Electroencephalography/methods; Ketamine/therapeutic use; Suicidal Ideation; Suicide}},
  language     = {{eng}},
  month        = {{04}},
  number       = {{4}},
  pages        = {{259--267}},
  publisher    = {{Cambridge University Press}},
  series       = {{International Journal of Neuropsychopharmacology}},
  title        = {{Spectral Changes of EEG Following a 6-Week Low-Dose Oral Ketamine Treatment in Adults With Major Depressive Disorder and Chronic Suicidality}},
  url          = {{http://dx.doi.org/10.1093/ijnp/pyad006}},
  doi          = {{10.1093/ijnp/pyad006}},
  volume       = {{26}},
  year         = {{2023}},
}