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Percutaneous haemodynamic and renal support in patients presenting with decompensated heart failure : A multi-centre efficacy study using the Reitan Catheter Pump (RCP)

Keeble, Thomas R.; Karamasis, Grigoris V.; Rothman, Martin T.; Ricksten, Sven Erik; Ferrari, Markus; Hullin, Roger; Scherstén, Fredrik LU ; Reitan, Oyvind LU ; Kirking, Sebastian T. and Cleland, John G.F., et al. (2019) In International Journal of Cardiology 275. p.53-58
Abstract

Background: Worsening heart failure complicated by congestion, hypotension, and renal dysfunction is difficult to manage, increasingly common and predicts a poor outcome. Novel therapies are required to facilitate diuresis and implementation of disease-modifying interventions in preparation for hospital discharge. Accordingly, we investigated the haemodynamic and renal effects of the Reitan Catheter Pump (RCP) percutaneous support device in patients admitted with decompensated heart failure (DHF). Methods: This was a prospective observational study of 20 patients admitted with DHF, ejection fraction < 30%, and Cardiac index (CI) < 2.1 L/min/m2 in need of inotropic/mechanical support. Results: Patients underwent RCP... (More)

Background: Worsening heart failure complicated by congestion, hypotension, and renal dysfunction is difficult to manage, increasingly common and predicts a poor outcome. Novel therapies are required to facilitate diuresis and implementation of disease-modifying interventions in preparation for hospital discharge. Accordingly, we investigated the haemodynamic and renal effects of the Reitan Catheter Pump (RCP) percutaneous support device in patients admitted with decompensated heart failure (DHF). Methods: This was a prospective observational study of 20 patients admitted with DHF, ejection fraction < 30%, and Cardiac index (CI) < 2.1 L/min/m2 in need of inotropic/mechanical support. Results: Patients underwent RCP support for a mean of 18.3 (±6.3) hours. The RCP increased CI from 1.84 L/min/m2 (±0.27), to 2.41 L/min/m2 (±0.45, p = 0.04), increased urine output (71 mL/h (±65) to 227 ml/h (±179) (p = 0.006) with a concomitant reduction in serum creatinine (188 μmol/L (±87) to 161 μmol/L (±78) (p = 0.0007). There were no clinically significant haemolysis, vascular injury, or thrombo-embolic complications. Conclusions: For patients admitted with DHF, the RCP improves cardiac index, diuresis and renal function without causing important complications.

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publication status
published
subject
keywords
Cardiac support, Congestion, Decompensated heart failure, Renal dysfunction
in
International Journal of Cardiology
volume
275
pages
53 - 58
publisher
Elsevier
external identifiers
  • scopus:85054811365
ISSN
0167-5273
DOI
10.1016/j.ijcard.2018.09.085
language
English
LU publication?
yes
id
c645352e-b510-4a30-a653-9aab2699a237
date added to LUP
2018-10-30 15:43:13
date last changed
2019-02-20 11:34:01
@article{c645352e-b510-4a30-a653-9aab2699a237,
  abstract     = {<p>Background: Worsening heart failure complicated by congestion, hypotension, and renal dysfunction is difficult to manage, increasingly common and predicts a poor outcome. Novel therapies are required to facilitate diuresis and implementation of disease-modifying interventions in preparation for hospital discharge. Accordingly, we investigated the haemodynamic and renal effects of the Reitan Catheter Pump (RCP) percutaneous support device in patients admitted with decompensated heart failure (DHF). Methods: This was a prospective observational study of 20 patients admitted with DHF, ejection fraction &lt; 30%, and Cardiac index (CI) &lt; 2.1 L/min/m<sup>2</sup> in need of inotropic/mechanical support. Results: Patients underwent RCP support for a mean of 18.3 (±6.3) hours. The RCP increased CI from 1.84 L/min/m<sup>2</sup> (±0.27), to 2.41 L/min/m<sup>2</sup> (±0.45, p = 0.04), increased urine output (71 mL/h (±65) to 227 ml/h (±179) (p = 0.006) with a concomitant reduction in serum creatinine (188 μmol/L (±87) to 161 μmol/L (±78) (p = 0.0007). There were no clinically significant haemolysis, vascular injury, or thrombo-embolic complications. Conclusions: For patients admitted with DHF, the RCP improves cardiac index, diuresis and renal function without causing important complications.</p>},
  author       = {Keeble, Thomas R. and Karamasis, Grigoris V. and Rothman, Martin T. and Ricksten, Sven Erik and Ferrari, Markus and Hullin, Roger and Scherstén, Fredrik and Reitan, Oyvind and Kirking, Sebastian T. and Cleland, John G.F. and Smith, Elliot J.},
  issn         = {0167-5273},
  keyword      = {Cardiac support,Congestion,Decompensated heart failure,Renal dysfunction},
  language     = {eng},
  pages        = {53--58},
  publisher    = {Elsevier},
  series       = {International Journal of Cardiology},
  title        = {Percutaneous haemodynamic and renal support in patients presenting with decompensated heart failure : A multi-centre efficacy study using the Reitan Catheter Pump (RCP)},
  url          = {http://dx.doi.org/10.1016/j.ijcard.2018.09.085},
  volume       = {275},
  year         = {2019},
}