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Experimental toolkit to study the oncogenic role of WNT signaling in colorectal cancer

Dash, Pujarini LU ; Yadav, Vikas LU orcid ; Das, Biswajit and Satapathy, Shakti Ranjan LU (2025) In Biochimica et Biophysica Acta - Reviews on Cancer 1880(4). p.1-23
Abstract
Colorectal cancer (CRC) is linked to the WNT/β-catenin signaling as its primary driver. Aberrant activation of WNT/β-catenin signaling is closely correlated with increased incidence, malignancy, poorer prognosis, and even higher cancer-related death. Research over the years has postulated various experimental models that have facilitated an understanding of the complex mechanisms underlying WNT signaling in CRC. In the present review, we have comprehensively summarized the in vitro, in vivo, patient-derived, and computational models used to study the role of WNT signaling in CRC. We discuss the use of CRC cell lines and organoids in capturing the molecular intricacies of WNT signaling and implementing xenograft and genetically engineered... (More)
Colorectal cancer (CRC) is linked to the WNT/β-catenin signaling as its primary driver. Aberrant activation of WNT/β-catenin signaling is closely correlated with increased incidence, malignancy, poorer prognosis, and even higher cancer-related death. Research over the years has postulated various experimental models that have facilitated an understanding of the complex mechanisms underlying WNT signaling in CRC. In the present review, we have comprehensively summarized the in vitro, in vivo, patient-derived, and computational models used to study the role of WNT signaling in CRC. We discuss the use of CRC cell lines and organoids in capturing the molecular intricacies of WNT signaling and implementing xenograft and genetically engineered mouse models to mimic the tumor microenvironment. Patient-derived models, including xenografts and organoids, provide valuable insights into personalized medicine approaches. Additionally, we elaborated on the role of computational models in simulating WNT signaling dynamics and predicting therapeutic outcomes. By evaluating the advantages and limitations of each model, this review highlights the critical contributions of these systems to our understanding of WNT signaling in CRC. We emphasize the need to integrate diverse model systems to enhance translational research and clinical applications, which is the primary goal of this review. (Less)
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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Biochimica et Biophysica Acta - Reviews on Cancer
volume
1880
issue
4
article number
189354
pages
1 - 23
publisher
Elsevier
external identifiers
  • pmid:40414319
ISSN
0304-419X
DOI
10.1016/j.bbcan.2025.189354
language
English
LU publication?
yes
id
c6d49b73-9a01-470b-8e79-a24d7033b533
date added to LUP
2025-05-29 17:20:11
date last changed
2025-06-02 09:05:59
@article{c6d49b73-9a01-470b-8e79-a24d7033b533,
  abstract     = {{Colorectal cancer (CRC) is linked to the WNT/β-catenin signaling as its primary driver. Aberrant activation of WNT/β-catenin signaling is closely correlated with increased incidence, malignancy, poorer prognosis, and even higher cancer-related death. Research over the years has postulated various experimental models that have facilitated an understanding of the complex mechanisms underlying WNT signaling in CRC. In the present review, we have comprehensively summarized the in vitro, in vivo, patient-derived, and computational models used to study the role of WNT signaling in CRC. We discuss the use of CRC cell lines and organoids in capturing the molecular intricacies of WNT signaling and implementing xenograft and genetically engineered mouse models to mimic the tumor microenvironment. Patient-derived models, including xenografts and organoids, provide valuable insights into personalized medicine approaches. Additionally, we elaborated on the role of computational models in simulating WNT signaling dynamics and predicting therapeutic outcomes. By evaluating the advantages and limitations of each model, this review highlights the critical contributions of these systems to our understanding of WNT signaling in CRC. We emphasize the need to integrate diverse model systems to enhance translational research and clinical applications, which is the primary goal of this review.}},
  author       = {{Dash, Pujarini and Yadav, Vikas and Das, Biswajit and Satapathy, Shakti Ranjan}},
  issn         = {{0304-419X}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{1--23}},
  publisher    = {{Elsevier}},
  series       = {{Biochimica et Biophysica Acta - Reviews on Cancer}},
  title        = {{Experimental toolkit to study the oncogenic role of WNT signaling in colorectal cancer}},
  url          = {{http://dx.doi.org/10.1016/j.bbcan.2025.189354}},
  doi          = {{10.1016/j.bbcan.2025.189354}},
  volume       = {{1880}},
  year         = {{2025}},
}