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Can the Reactivity to Chromate Be Changed in Patch Testing Using a Barrier Cream?

Lejding, Tina LU orcid ; Bruze, Magnus LU ; Engfeldt, Malin LU ; Isaksson, Marléne LU ; Svedman, Cecilia LU ; Zimerson, Erik LU and Mowitz, Martin LU (2020) In Dermatitis 31(6). p.373-377
Abstract
The persistent, difficult-to-treat, allergic contact dermatitis from hexavalent chromium in European construction workers has diminished significantly since the legislative measurements that came into force in January 2005. However, sensitization to hexavalent chromium continues to be a problem. Barrier creams have been tried for various allergens with divergent results. Objective The aim of the study was to investigate the protective capacity of barrier cream candidates against hexavalent chromium in a patch test situation. Methods An experimental study was performed to investigate the reductive properties of glutathione and iron sulfate on the patch test reactivity in chromium-allergic individuals when exposed to hexavalent chromium. In... (More)
The persistent, difficult-to-treat, allergic contact dermatitis from hexavalent chromium in European construction workers has diminished significantly since the legislative measurements that came into force in January 2005. However, sensitization to hexavalent chromium continues to be a problem. Barrier creams have been tried for various allergens with divergent results. Objective The aim of the study was to investigate the protective capacity of barrier cream candidates against hexavalent chromium in a patch test situation. Methods An experimental study was performed to investigate the reductive properties of glutathione and iron sulfate on the patch test reactivity in chromium-allergic individuals when exposed to hexavalent chromium. In this study, we also investigated the protective properties of a commercially available barrier cream. Conclusions A higher number of volunteers (16/18) showed reactions on the skin treated with the commercially available barrier cream, compared with the untreated skin (13/18) on test reading day 3/4 or day 7. The skin treated with petrolatum or Essex cream showed fewer and less prominent allergic reactions than the skin treated with the commercially available barrier cream. (Less)
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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Dermatitis
volume
31
issue
6
pages
373 - 377
publisher
Lippincott Williams & Wilkins
external identifiers
  • scopus:85096153551
  • pmid:33186332
ISSN
1710-3568
DOI
10.1097/DER.0000000000000539
language
English
LU publication?
yes
id
c6ee3947-dbd1-46f7-a182-d7f47f04a2ed
date added to LUP
2020-11-26 15:31:07
date last changed
2022-04-19 02:24:38
@article{c6ee3947-dbd1-46f7-a182-d7f47f04a2ed,
  abstract     = {{The persistent, difficult-to-treat, allergic contact dermatitis from hexavalent chromium in European construction workers has diminished significantly since the legislative measurements that came into force in January 2005. However, sensitization to hexavalent chromium continues to be a problem. Barrier creams have been tried for various allergens with divergent results. Objective The aim of the study was to investigate the protective capacity of barrier cream candidates against hexavalent chromium in a patch test situation. Methods An experimental study was performed to investigate the reductive properties of glutathione and iron sulfate on the patch test reactivity in chromium-allergic individuals when exposed to hexavalent chromium. In this study, we also investigated the protective properties of a commercially available barrier cream. Conclusions A higher number of volunteers (16/18) showed reactions on the skin treated with the commercially available barrier cream, compared with the untreated skin (13/18) on test reading day 3/4 or day 7. The skin treated with petrolatum or Essex cream showed fewer and less prominent allergic reactions than the skin treated with the commercially available barrier cream.}},
  author       = {{Lejding, Tina and Bruze, Magnus and Engfeldt, Malin and Isaksson, Marléne and Svedman, Cecilia and Zimerson, Erik and Mowitz, Martin}},
  issn         = {{1710-3568}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{373--377}},
  publisher    = {{Lippincott Williams & Wilkins}},
  series       = {{Dermatitis}},
  title        = {{Can the Reactivity to Chromate Be Changed in Patch Testing Using a Barrier Cream?}},
  url          = {{http://dx.doi.org/10.1097/DER.0000000000000539}},
  doi          = {{10.1097/DER.0000000000000539}},
  volume       = {{31}},
  year         = {{2020}},
}