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Triiodothyronine (T3) levels in relation to mortality from breast cancer and all-causes: a population-based prospective cohort study.

Tosovic, Ada LU ; Bondeson, Anne-Greth LU ; Bondeson, Lennart LU ; Ericsson, Ulla-Britt and Manjer, Jonas LU (2013) In European Journal of Endocrinology1994-01-01+01:00 168(4). p.483-490
Abstract
OBJECTIVE: The potential association between thyroid hormones and breast cancer has been investigated in a large number of studies without conclusive results. This study investigated T3 levels in relation to breast cancer mortality in a population with no breast cancer patients at baseline. An additional aim was to study T3 levels in relation to mortality from other cancers and all-cause mortality. DESIGN AND METHODS: This was a population-based prospective cohort study including 2,185 women in whom T3 levels were measured as part of a preventive health project, i.e. before diagnosis in women who later developed breast cancer. Mean follow-up was 24.1 years and record-linkage to The Swedish Cause-of-Death registry identified 471 women who... (More)
OBJECTIVE: The potential association between thyroid hormones and breast cancer has been investigated in a large number of studies without conclusive results. This study investigated T3 levels in relation to breast cancer mortality in a population with no breast cancer patients at baseline. An additional aim was to study T3 levels in relation to mortality from other cancers and all-cause mortality. DESIGN AND METHODS: This was a population-based prospective cohort study including 2,185 women in whom T3 levels were measured as part of a preventive health project, i.e. before diagnosis in women who later developed breast cancer. Mean follow-up was 24.1 years and record-linkage to The Swedish Cause-of-Death registry identified 471 women who died; 26 out of breast cancer, and 182 from other cancers. Mortality was assessed using a Cox's analysis, yielding hazard ratios (HR), with 95% confidence intervals. Analyses of T3 as a continuous variable were repeated for pre- and peri/postmenopausal women separately. RESULTS: T3 levels were positively associated with the risk of breast cancer specific death in the age-adjusted analysis: HR for T3 as a continuous variable was 2.80 (1.26-6.25). However, the crude analysis did not reach statistical significance. Breast cancer mortality was even higher in postmenopausal women: 3.73 (1.69-8.22), but stratified analyses included few events. There were no statistically significant associations between T3 levels and deaths from other cancers, age-adjusted HR: 1.09 (0.72-1.65) or all-cause mortality (1.25:0.97-1.60). CONCLUSIONS: This study, the first of its kind on prospectively measured T3 levels, indicates that T3 levels are positively associated with breast cancer specific mortality, and that this is not related to a general effect on all-cause mortality. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
European Journal of Endocrinology1994-01-01+01:00
volume
168
issue
4
pages
483 - 490
publisher
Society of the European Journal of Endocrinology
external identifiers
  • wos:000317478700005
  • pmid:23258272
  • scopus:84875134721
ISSN
1479-683X
DOI
10.1530/EJE-12-0564
language
English
LU publication?
yes
id
c7465557-b3cc-41d7-a010-eab33b7f1f2a (old id 3347002)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23258272?dopt=Abstract
date added to LUP
2013-01-02 13:35:33
date last changed
2019-07-28 03:14:17
@article{c7465557-b3cc-41d7-a010-eab33b7f1f2a,
  abstract     = {OBJECTIVE: The potential association between thyroid hormones and breast cancer has been investigated in a large number of studies without conclusive results. This study investigated T3 levels in relation to breast cancer mortality in a population with no breast cancer patients at baseline. An additional aim was to study T3 levels in relation to mortality from other cancers and all-cause mortality. DESIGN AND METHODS: This was a population-based prospective cohort study including 2,185 women in whom T3 levels were measured as part of a preventive health project, i.e. before diagnosis in women who later developed breast cancer. Mean follow-up was 24.1 years and record-linkage to The Swedish Cause-of-Death registry identified 471 women who died; 26 out of breast cancer, and 182 from other cancers. Mortality was assessed using a Cox's analysis, yielding hazard ratios (HR), with 95% confidence intervals. Analyses of T3 as a continuous variable were repeated for pre- and peri/postmenopausal women separately. RESULTS: T3 levels were positively associated with the risk of breast cancer specific death in the age-adjusted analysis: HR for T3 as a continuous variable was 2.80 (1.26-6.25). However, the crude analysis did not reach statistical significance. Breast cancer mortality was even higher in postmenopausal women: 3.73 (1.69-8.22), but stratified analyses included few events. There were no statistically significant associations between T3 levels and deaths from other cancers, age-adjusted HR: 1.09 (0.72-1.65) or all-cause mortality (1.25:0.97-1.60). CONCLUSIONS: This study, the first of its kind on prospectively measured T3 levels, indicates that T3 levels are positively associated with breast cancer specific mortality, and that this is not related to a general effect on all-cause mortality.},
  author       = {Tosovic, Ada and Bondeson, Anne-Greth and Bondeson, Lennart and Ericsson, Ulla-Britt and Manjer, Jonas},
  issn         = {1479-683X},
  language     = {eng},
  number       = {4},
  pages        = {483--490},
  publisher    = {Society of the European Journal of Endocrinology},
  series       = {European Journal of Endocrinology1994-01-01+01:00},
  title        = {Triiodothyronine (T3) levels in relation to mortality from breast cancer and all-causes: a population-based prospective cohort study.},
  url          = {http://dx.doi.org/10.1530/EJE-12-0564},
  volume       = {168},
  year         = {2013},
}