Urodynamic factors influence the duration of Escherichia coli bacteriuria in deliberately colonized cases
(1998) In Journal of Urology 159(6). p.2057-2062- Abstract
Purpose: We evaluated the influence of urodynamic factors on the establishment of bacteriuria, after deliberate intravesical inoculation with Escherichia coli. Materials and Methods: Nine women and 7 men with recurrent symptomatic urinary tract infections underwent intravesical injection of E. coli 83972. This strain had documented ability to persist in the urinary tract and it lacks expressed virulence factors associated with urinary tract infection. Results: Successful long-term colonization (5 months to 3 years) was achieved in 6 of 12 patients with neurogenic bladder disorder, including normal or high bladder capacity, normal or low detrusor pressure and residual urine. Short-term bacteriuria (13 days) occurred in 1 but long-term... (More)
Purpose: We evaluated the influence of urodynamic factors on the establishment of bacteriuria, after deliberate intravesical inoculation with Escherichia coli. Materials and Methods: Nine women and 7 men with recurrent symptomatic urinary tract infections underwent intravesical injection of E. coli 83972. This strain had documented ability to persist in the urinary tract and it lacks expressed virulence factors associated with urinary tract infection. Results: Successful long-term colonization (5 months to 3 years) was achieved in 6 of 12 patients with neurogenic bladder disorder, including normal or high bladder capacity, normal or low detrusor pressure and residual urine. Short-term bacteriuria (13 days) occurred in 1 but long-term bacteriuria was not established in the 4 patients with normal lower urinary tract function. Occasionally urine samples from the colonized patients contained other bacterial strains, which cleared spontaneously except for a Klebsiella strain that became established in 2 and subsequently eliminated E. coli 83972. Conclusions: E. coli 83972 bacteriuria could only be established in a subset of patients with defective bladder voiding, suggesting that urodynamic defects permit a nonvirulent strain to establish in the urinary tract, but that additional host factors determine if bacteriuria will persist.
(Less)
- author
- Wullt, Björn LU ; Connell, Hugh LU ; Röllano, Piotr ; Månsson, Wiking LU ; Colleen, Stig LU and Svanborg, Catharina LU
- publishing date
- 1998-06
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Bacteriuria, Bladder, Escherichia coli, Urinary tract infections, Urodynamics
- in
- Journal of Urology
- volume
- 159
- issue
- 6
- pages
- 6 pages
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- scopus:0032413751
- pmid:9598517
- ISSN
- 0022-5347
- DOI
- 10.1016/S0022-5347(01)63246-4
- language
- English
- LU publication?
- no
- id
- c75b97a6-cafe-4a54-afe5-300792e18bc8
- date added to LUP
- 2019-06-19 14:09:13
- date last changed
- 2025-01-09 15:18:16
@article{c75b97a6-cafe-4a54-afe5-300792e18bc8,
abstract = {{<p>Purpose: We evaluated the influence of urodynamic factors on the establishment of bacteriuria, after deliberate intravesical inoculation with Escherichia coli. Materials and Methods: Nine women and 7 men with recurrent symptomatic urinary tract infections underwent intravesical injection of E. coli 83972. This strain had documented ability to persist in the urinary tract and it lacks expressed virulence factors associated with urinary tract infection. Results: Successful long-term colonization (5 months to 3 years) was achieved in 6 of 12 patients with neurogenic bladder disorder, including normal or high bladder capacity, normal or low detrusor pressure and residual urine. Short-term bacteriuria (13 days) occurred in 1 but long-term bacteriuria was not established in the 4 patients with normal lower urinary tract function. Occasionally urine samples from the colonized patients contained other bacterial strains, which cleared spontaneously except for a Klebsiella strain that became established in 2 and subsequently eliminated E. coli 83972. Conclusions: E. coli 83972 bacteriuria could only be established in a subset of patients with defective bladder voiding, suggesting that urodynamic defects permit a nonvirulent strain to establish in the urinary tract, but that additional host factors determine if bacteriuria will persist.</p>}},
author = {{Wullt, Björn and Connell, Hugh and Röllano, Piotr and Månsson, Wiking and Colleen, Stig and Svanborg, Catharina}},
issn = {{0022-5347}},
keywords = {{Bacteriuria; Bladder; Escherichia coli; Urinary tract infections; Urodynamics}},
language = {{eng}},
number = {{6}},
pages = {{2057--2062}},
publisher = {{Lippincott Williams & Wilkins}},
series = {{Journal of Urology}},
title = {{Urodynamic factors influence the duration of Escherichia coli bacteriuria in deliberately colonized cases}},
url = {{http://dx.doi.org/10.1016/S0022-5347(01)63246-4}},
doi = {{10.1016/S0022-5347(01)63246-4}},
volume = {{159}},
year = {{1998}},
}