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Who Still Gets Ligated? Reasons for Persistence of Surgical Ligation of the Patent Ductus Arteriosus Following Availability of Transcatheter Device Occlusion for Premature Neonates

Hoffmann, Julia K. ; Khazal, Zahra ; Apers, Wievineke ; Sharma, Puneet ; Weismann, Constance G. LU orcid ; Kaganov, Kira ; Wheeler, Craig R. ; Farias, Michael ; Porras, Diego and Levy, Philip , et al. (2024) In Journal of cardiovascular development and disease 11(5).
Abstract

(1) Background: To identify reasons for the persistence of surgical ligation of the patent ductus arteriosus (PDA) in premature infants after the 2019 Food and Drug Administration (FDA) approval of transcatheter device closure; (2) Methods: We performed a 10-year (2014–2023) single-institution retrospective study of premature infants (<37 weeks) and compared clinical characteristics and neonatal morbidities between neonates that underwent surgical ligation before (epoch 1) and after (epoch 2) FDA approval of transcatheter closure; (3) Results: We identified 120 premature infants that underwent surgical ligation (n = 94 before, n = 26 after FDA approval). Unfavorable PDA morphology, active infection, and recent abdominal pathology... (More)

(1) Background: To identify reasons for the persistence of surgical ligation of the patent ductus arteriosus (PDA) in premature infants after the 2019 Food and Drug Administration (FDA) approval of transcatheter device closure; (2) Methods: We performed a 10-year (2014–2023) single-institution retrospective study of premature infants (<37 weeks) and compared clinical characteristics and neonatal morbidities between neonates that underwent surgical ligation before (epoch 1) and after (epoch 2) FDA approval of transcatheter closure; (3) Results: We identified 120 premature infants that underwent surgical ligation (n = 94 before, n = 26 after FDA approval). Unfavorable PDA morphology, active infection, and recent abdominal pathology were the most common reasons for surgical ligation over device occlusion in epoch 2. There were no differences in demographics, age at closure, or outcomes between infants who received surgical ligation in the two epochs; (4) Conclusions: Despite increasing trends for transcatheter PDA closure in premature infants, surgical ligation persists due to unfavorable ductal morphology, active infection, or abdominal pathology.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
patent ductus arteriosus, PDA, prematurity, surgical ligation
in
Journal of cardiovascular development and disease
volume
11
issue
5
article number
132
publisher
MDPI AG
external identifiers
  • scopus:85193963911
  • pmid:38786954
ISSN
2308-3425
DOI
10.3390/jcdd11050132
language
English
LU publication?
yes
id
c767b71b-cc75-4390-90eb-b89e803e19ae
date added to LUP
2024-06-05 10:52:22
date last changed
2024-06-19 11:39:33
@article{c767b71b-cc75-4390-90eb-b89e803e19ae,
  abstract     = {{<p>(1) Background: To identify reasons for the persistence of surgical ligation of the patent ductus arteriosus (PDA) in premature infants after the 2019 Food and Drug Administration (FDA) approval of transcatheter device closure; (2) Methods: We performed a 10-year (2014–2023) single-institution retrospective study of premature infants (&lt;37 weeks) and compared clinical characteristics and neonatal morbidities between neonates that underwent surgical ligation before (epoch 1) and after (epoch 2) FDA approval of transcatheter closure; (3) Results: We identified 120 premature infants that underwent surgical ligation (n = 94 before, n = 26 after FDA approval). Unfavorable PDA morphology, active infection, and recent abdominal pathology were the most common reasons for surgical ligation over device occlusion in epoch 2. There were no differences in demographics, age at closure, or outcomes between infants who received surgical ligation in the two epochs; (4) Conclusions: Despite increasing trends for transcatheter PDA closure in premature infants, surgical ligation persists due to unfavorable ductal morphology, active infection, or abdominal pathology.</p>}},
  author       = {{Hoffmann, Julia K. and Khazal, Zahra and Apers, Wievineke and Sharma, Puneet and Weismann, Constance G. and Kaganov, Kira and Wheeler, Craig R. and Farias, Michael and Porras, Diego and Levy, Philip and Morton, Sarah U.}},
  issn         = {{2308-3425}},
  keywords     = {{patent ductus arteriosus; PDA; prematurity; surgical ligation}},
  language     = {{eng}},
  number       = {{5}},
  publisher    = {{MDPI AG}},
  series       = {{Journal of cardiovascular development and disease}},
  title        = {{Who Still Gets Ligated? Reasons for Persistence of Surgical Ligation of the Patent Ductus Arteriosus Following Availability of Transcatheter Device Occlusion for Premature Neonates}},
  url          = {{http://dx.doi.org/10.3390/jcdd11050132}},
  doi          = {{10.3390/jcdd11050132}},
  volume       = {{11}},
  year         = {{2024}},
}