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SARS-CoV-2, Testosterone and frailty in males (PROTEGGIMI) : A multidimensional research project

Salonia, Andrea ; Corona, Giovanni ; Giwercman, Aleksander LU ; Maggi, Mario ; Minhas, Suks ; Nappi, Rossella E. ; Sofikitis, Nikolaos and Vignozzi, Linda (2021) In Andrology 9(1). p.19-22
Abstract

Preliminary published data depicts a much greater prevalence of malewith laboratory-confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) referred for intensive care unit admission and severe sequelae in several countries. In this context, males seem to not only be more susceptible to the infection compared to female subjects, at least in western countries, but their case fatality rate attributable to SARS-CoV-2 infection is also highest. Therefore, we may speculate that the different hormonal milieu could have a more profound pathophysiological role in association with SARS-CoV-2, with endogenous testosterone leaving men more prone to develop more serious complications related to the SARS-CoV-2 infection. Another... (More)

Preliminary published data depicts a much greater prevalence of malewith laboratory-confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) referred for intensive care unit admission and severe sequelae in several countries. In this context, males seem to not only be more susceptible to the infection compared to female subjects, at least in western countries, but their case fatality rate attributable to SARS-CoV-2 infection is also highest. Therefore, we may speculate that the different hormonal milieu could have a more profound pathophysiological role in association with SARS-CoV-2, with endogenous testosterone leaving men more prone to develop more serious complications related to the SARS-CoV-2 infection. Another option is that SARS-CoV-2 infection per se causes an acute stage of male hypogonadism, the depletion of androgenic action triggering serious or an even fatal course of the disease. Therefore, we stongly advocate the development of a prospective multidimensional andrological translational research project in men, which we called the PROTEGGIMI study. In this Opinion Article we will not only highlight novel research activity in this area but also invite other researchers and learned scientific societies to join us in our efforts to understand an important and very newly discovered gap in knowledge, which may have serious implications for the lives of millions of men.

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author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
ACE2, andrology, COVID-19, endocrinology, male infertility, SARS-CoV-2, testosterone, urology
in
Andrology
volume
9
issue
1
pages
19 - 22
publisher
Wiley-Blackwell
external identifiers
  • pmid:32369678
  • scopus:85084616727
ISSN
2047-2927
DOI
10.1111/andr.12811
language
English
LU publication?
yes
id
c76e6730-e5a4-4075-a5de-3449091e2a8d
date added to LUP
2020-06-09 11:33:24
date last changed
2024-05-15 11:53:32
@article{c76e6730-e5a4-4075-a5de-3449091e2a8d,
  abstract     = {{<p>Preliminary published data depicts a much greater prevalence of malewith laboratory-confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) referred for intensive care unit admission and severe sequelae in several countries. In this context, males seem to not only be more susceptible to the infection compared to female subjects, at least in western countries, but their case fatality rate attributable to SARS-CoV-2 infection is also highest. Therefore, we may speculate that the different hormonal milieu could have a more profound pathophysiological role in association with SARS-CoV-2, with endogenous testosterone leaving men more prone to develop more serious complications related to the SARS-CoV-2 infection. Another option is that SARS-CoV-2 infection per se causes an acute stage of male hypogonadism, the depletion of androgenic action triggering serious or an even fatal course of the disease. Therefore, we stongly advocate the development of a prospective multidimensional andrological translational research project in men, which we called the PROTEGGIMI study. In this Opinion Article we will not only highlight novel research activity in this area but also invite other researchers and learned scientific societies to join us in our efforts to understand an important and very newly discovered gap in knowledge, which may have serious implications for the lives of millions of men.</p>}},
  author       = {{Salonia, Andrea and Corona, Giovanni and Giwercman, Aleksander and Maggi, Mario and Minhas, Suks and Nappi, Rossella E. and Sofikitis, Nikolaos and Vignozzi, Linda}},
  issn         = {{2047-2927}},
  keywords     = {{ACE2; andrology; COVID-19; endocrinology; male infertility; SARS-CoV-2; testosterone; urology}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{19--22}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Andrology}},
  title        = {{SARS-CoV-2, Testosterone and frailty in males (PROTEGGIMI) : A multidimensional research project}},
  url          = {{http://dx.doi.org/10.1111/andr.12811}},
  doi          = {{10.1111/andr.12811}},
  volume       = {{9}},
  year         = {{2021}},
}