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Molecular imprinting on microgel spheres

Ye, Lei LU ; Cormack, Peter A G and Mosbach, Klaus LU (2001) In Analytica Chimica Acta 435(1). p.187-196
Abstract

Molecularly imprinted polymers have been prepared in various configurations including, for example, polymer beads, monoliths and membranes for different applications. The most common form of imprinted polymer is, however, still the irregularly shaped particle obtained by grinding the traditional, macroporous polymer monolith. We herein present a novel and efficient approach leading to imprinted microspheres, i.e. microgels bearing binding sites specific to target molecules. Imprinted microgels are proposed to be the basic components in previously reported, molecularly imprinted, cross-linked polymers, although the polymers themselves may exist in different forms depending on the preparation method utilised. Chemical modification of the... (More)

Molecularly imprinted polymers have been prepared in various configurations including, for example, polymer beads, monoliths and membranes for different applications. The most common form of imprinted polymer is, however, still the irregularly shaped particle obtained by grinding the traditional, macroporous polymer monolith. We herein present a novel and efficient approach leading to imprinted microspheres, i.e. microgels bearing binding sites specific to target molecules. Imprinted microgels are proposed to be the basic components in previously reported, molecularly imprinted, cross-linked polymers, although the polymers themselves may exist in different forms depending on the preparation method utilised. Chemical modification of the molecularly imprinted microspheres introduces additional functionalities that may be used to couple sensing elements in various assay formats, or for the immobilisation of the imprinted microspheres on various transducers towards the development of biomimetic sensors.

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Contribution to journal
publication status
published
subject
keywords
17β-estradiol, Microgel, Microspheres, Molecular imprinting, Precipitation polymerisation, Theophylline
in
Analytica Chimica Acta
volume
435
issue
1
pages
10 pages
publisher
Elsevier
external identifiers
  • scopus:0035901859
ISSN
0003-2670
DOI
10.1016/S0003-2670(00)01248-4
language
English
LU publication?
yes
id
c77b75cf-40dc-4594-ac92-150521b365de
date added to LUP
2019-06-18 08:56:20
date last changed
2020-11-24 03:55:50
@article{c77b75cf-40dc-4594-ac92-150521b365de,
  abstract     = {<p>Molecularly imprinted polymers have been prepared in various configurations including, for example, polymer beads, monoliths and membranes for different applications. The most common form of imprinted polymer is, however, still the irregularly shaped particle obtained by grinding the traditional, macroporous polymer monolith. We herein present a novel and efficient approach leading to imprinted microspheres, i.e. microgels bearing binding sites specific to target molecules. Imprinted microgels are proposed to be the basic components in previously reported, molecularly imprinted, cross-linked polymers, although the polymers themselves may exist in different forms depending on the preparation method utilised. Chemical modification of the molecularly imprinted microspheres introduces additional functionalities that may be used to couple sensing elements in various assay formats, or for the immobilisation of the imprinted microspheres on various transducers towards the development of biomimetic sensors.</p>},
  author       = {Ye, Lei and Cormack, Peter A G and Mosbach, Klaus},
  issn         = {0003-2670},
  language     = {eng},
  month        = {05},
  number       = {1},
  pages        = {187--196},
  publisher    = {Elsevier},
  series       = {Analytica Chimica Acta},
  title        = {Molecular imprinting on microgel spheres},
  url          = {http://dx.doi.org/10.1016/S0003-2670(00)01248-4},
  doi          = {10.1016/S0003-2670(00)01248-4},
  volume       = {435},
  year         = {2001},
}