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Expression of microRNA-1234 related signal transducer and activator of transcription 3 in patients with diffuse large B-cell lymphoma of activated B-cell like type from high and low infectious disease areas

Högfeldt, Therese; Johnsson, Per; Grandér, Dan; Bahnassy, Abeer A.; Porwit, Anna LU ; Eid, Salem; Österborg, Anders; Zekri, Abdel Rahman N.; Lundahl, Joachim and Khaled, Mustafa Hussein, et al. (2014) In Leukemia and Lymphoma 55(5). p.1158-1165
Abstract

Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous disease, and infectious agents are suspected to be involved in the tumorigenesis of DLBCL. MicroRNAs (miRNAs) are non-coding RNAs modulating protein expression. We compared miRNA expression profiles in lymph node tissues of patients with DLBCL of the activated B-cell like (ABC) type from two geographical areas with different background exposures, Sweden and Egypt. We showed previously that DLBCL tissues of the ABC-type in Swedish patients had a higher expression of signal transducer and activator of transcription 3 (STAT3) compared to Egyptian patients. Here, we analyzed the involvement of miRNAs in STAT3 regulation. miR-1234 was significantly up-regulated in Egyptian patients... (More)

Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous disease, and infectious agents are suspected to be involved in the tumorigenesis of DLBCL. MicroRNAs (miRNAs) are non-coding RNAs modulating protein expression. We compared miRNA expression profiles in lymph node tissues of patients with DLBCL of the activated B-cell like (ABC) type from two geographical areas with different background exposures, Sweden and Egypt. We showed previously that DLBCL tissues of the ABC-type in Swedish patients had a higher expression of signal transducer and activator of transcription 3 (STAT3) compared to Egyptian patients. Here, we analyzed the involvement of miRNAs in STAT3 regulation. miR-1234 was significantly up-regulated in Egyptian patients with DLBCL compared to Swedish patients (p < 0.03). The miR-1234 expression level correlated inversely with the expression of STAT3. The Stat3 protein was down-regulated in cells transfected with miR-1234, suggesting that STAT3 might be a potential target for miR-1234. miR-1234 and STAT3 might be involved in the tumorigenesis of DLBCL of ABC type and possibly associated with environmental background exposure.

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publishing date
type
Contribution to journal
publication status
published
keywords
DLBCL, MiRNA, STAT3
in
Leukemia and Lymphoma
volume
55
issue
5
pages
1158 - 1165
publisher
Taylor & Francis
external identifiers
  • scopus:84899753536
ISSN
1042-8194
DOI
10.3109/10428194.2013.824077
language
English
LU publication?
no
id
c79a6494-7296-47b3-a5d4-ec0b20b6ec4e
date added to LUP
2019-05-22 09:52:25
date last changed
2019-07-09 04:46:12
@article{c79a6494-7296-47b3-a5d4-ec0b20b6ec4e,
  abstract     = {<p>Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous disease, and infectious agents are suspected to be involved in the tumorigenesis of DLBCL. MicroRNAs (miRNAs) are non-coding RNAs modulating protein expression. We compared miRNA expression profiles in lymph node tissues of patients with DLBCL of the activated B-cell like (ABC) type from two geographical areas with different background exposures, Sweden and Egypt. We showed previously that DLBCL tissues of the ABC-type in Swedish patients had a higher expression of signal transducer and activator of transcription 3 (STAT3) compared to Egyptian patients. Here, we analyzed the involvement of miRNAs in STAT3 regulation. miR-1234 was significantly up-regulated in Egyptian patients with DLBCL compared to Swedish patients (p &lt; 0.03). The miR-1234 expression level correlated inversely with the expression of STAT3. The Stat3 protein was down-regulated in cells transfected with miR-1234, suggesting that STAT3 might be a potential target for miR-1234. miR-1234 and STAT3 might be involved in the tumorigenesis of DLBCL of ABC type and possibly associated with environmental background exposure.</p>},
  author       = {Högfeldt, Therese and Johnsson, Per and Grandér, Dan and Bahnassy, Abeer A. and Porwit, Anna and Eid, Salem and Österborg, Anders and Zekri, Abdel Rahman N. and Lundahl, Joachim and Khaled, Mustafa Hussein and Mellstedt, Håkan and Moshfegh, Ali},
  issn         = {1042-8194},
  keyword      = {DLBCL,MiRNA,STAT3},
  language     = {eng},
  month        = {01},
  number       = {5},
  pages        = {1158--1165},
  publisher    = {Taylor & Francis},
  series       = {Leukemia and Lymphoma},
  title        = {Expression of microRNA-1234 related signal transducer and activator of transcription 3 in patients with diffuse large B-cell lymphoma of activated B-cell like type from high and low infectious disease areas},
  url          = {http://dx.doi.org/10.3109/10428194.2013.824077},
  volume       = {55},
  year         = {2014},
}