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Laser-based gas absorption spectroscopy in decaying hip bone : water vapor as a predictor of osteonecrosis

Chen, Delong ; Li, Wansha ; He, Wei ; Zhang, Hao ; Zhang, Qingwen ; Lin, Huiying ; Svanberg, Sune LU ; Svanberg, Katarina LU and Chen, Peng (2019) In Journal of Biomedical Optics 24(6). p.1-6
Abstract

Affluent blood flow through a complicated net of vessels supplies skeletal bone tissue with oxygen and nutrients. Due to accidental events or physiological processes, the blood supply might be deficient or even disrupted, and the healthy bone decays in a process that, for the hip location, is denoted as osteonecrosis of the femoral head (ONFH) or avascular femoral head necrosis. Early diagnosis is important for the prognosis. X-ray-based imaging, such as CT or MRI, is not of much value for the early detection. As the decay theoretically is associated with the development of gas-filled pores, gas analysis should have diagnostic value. We have introduced gas in scattering media absorption spectroscopy, as a complementary modality.... (More)

Affluent blood flow through a complicated net of vessels supplies skeletal bone tissue with oxygen and nutrients. Due to accidental events or physiological processes, the blood supply might be deficient or even disrupted, and the healthy bone decays in a process that, for the hip location, is denoted as osteonecrosis of the femoral head (ONFH) or avascular femoral head necrosis. Early diagnosis is important for the prognosis. X-ray-based imaging, such as CT or MRI, is not of much value for the early detection. As the decay theoretically is associated with the development of gas-filled pores, gas analysis should have diagnostic value. We have introduced gas in scattering media absorption spectroscopy, as a complementary modality. Eighteen extracted femoral joint heads, diseased as well as normal, were investigated. Diseased samples are associated with clear signals due to water vapor, whereas the normal ones largely lack such features. The results suggest that free water vapor could serve as an early indicator of pore development and thus as a promising predictor of ONFH pathological changes, once the technique has been fully refined.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
free water vapor, laser spectroscopy, osteonecrosis of the femoral head, predictor
in
Journal of Biomedical Optics
volume
24
issue
6
article number
065001
pages
6 pages
publisher
Published by SPIE--the International Society for Optical Engineering in cooperation with International Biomedical Optics Society
external identifiers
  • pmid:31230426
  • scopus:85068584715
ISSN
1083-3668
DOI
10.1117/1.JBO.24.6.065001
language
English
LU publication?
yes
id
c7bba10a-cc6f-40b3-90e1-fd62f9c2fab1
date added to LUP
2019-07-17 10:53:02
date last changed
2020-01-13 02:14:05
@article{c7bba10a-cc6f-40b3-90e1-fd62f9c2fab1,
  abstract     = {<p>Affluent blood flow through a complicated net of vessels supplies skeletal bone tissue with oxygen and nutrients. Due to accidental events or physiological processes, the blood supply might be deficient or even disrupted, and the healthy bone decays in a process that, for the hip location, is denoted as osteonecrosis of the femoral head (ONFH) or avascular femoral head necrosis. Early diagnosis is important for the prognosis. X-ray-based imaging, such as CT or MRI, is not of much value for the early detection. As the decay theoretically is associated with the development of gas-filled pores, gas analysis should have diagnostic value. We have introduced gas in scattering media absorption spectroscopy, as a complementary modality. Eighteen extracted femoral joint heads, diseased as well as normal, were investigated. Diseased samples are associated with clear signals due to water vapor, whereas the normal ones largely lack such features. The results suggest that free water vapor could serve as an early indicator of pore development and thus as a promising predictor of ONFH pathological changes, once the technique has been fully refined.</p>},
  author       = {Chen, Delong and Li, Wansha and He, Wei and Zhang, Hao and Zhang, Qingwen and Lin, Huiying and Svanberg, Sune and Svanberg, Katarina and Chen, Peng},
  issn         = {1083-3668},
  language     = {eng},
  month        = {06},
  number       = {6},
  pages        = {1--6},
  publisher    = {Published by SPIE--the International Society for Optical Engineering in cooperation with International Biomedical Optics Society},
  series       = {Journal of Biomedical Optics},
  title        = {Laser-based gas absorption spectroscopy in decaying hip bone : water vapor as a predictor of osteonecrosis},
  url          = {http://dx.doi.org/10.1117/1.JBO.24.6.065001},
  doi          = {10.1117/1.JBO.24.6.065001},
  volume       = {24},
  year         = {2019},
}