Family history of cardiometabolic diseases and its association with arterial stiffness in the Malmö Diet Cancer cohort
(2017) In Journal of Hypertension 35(11). p.2262-2267- Abstract
OBJECTIVE:: Arterial stiffening increases with age and is associated with increased cardiovascular risk. Several risk factors have been shown to predict the development of arterial stiffening; however, a positive family history (FH+) of cardiometabolic disease (CMD) and hypertension has not been extensively studied. We hypothesize that FH+ of CMD plays a significant role in the development of arterial stiffening in offspring. METHODS:: We used data from the population-based Malmö Diet Cancer study (n?=?3056) examined in 1992–1996 and again in 2007–2012. Several variables were analysed, including anthropometrics, carotid–femoral pulse wave velocity and FH+. The association between FH+ of CMD and arterial stiffening in the offspring was... (More)
OBJECTIVE:: Arterial stiffening increases with age and is associated with increased cardiovascular risk. Several risk factors have been shown to predict the development of arterial stiffening; however, a positive family history (FH+) of cardiometabolic disease (CMD) and hypertension has not been extensively studied. We hypothesize that FH+ of CMD plays a significant role in the development of arterial stiffening in offspring. METHODS:: We used data from the population-based Malmö Diet Cancer study (n?=?3056) examined in 1992–1996 and again in 2007–2012. Several variables were analysed, including anthropometrics, carotid–femoral pulse wave velocity and FH+. The association between FH+ of CMD and arterial stiffening in the offspring was analysed with analysis of covariance in SPSS. FH+ was subdivided into three categories: family history for cardiovascular events (FH-CVEs), family history for diabetes mellitus type 2 (FH-DM2) and family history for hypertension (FH-HT). The first analysis of covariance-model was adjusted for age, sex, mean arterial pressure and heart rate; the second model additionally adjusted for self-reported medical history in the offspring. RESULTS:: Data indicated that FH-CVE (F?=?14.64, P?<?0.001), FH-DM2 (F?=?18.57, P?<?0.001) and FH-HT (F?=?13.92, P?<?0.001) all significantly increased carotid–femoral pulse wave velocity levels. The results remained when additional adjustment was made for confounders and for self-reported CMD in the index participants, respectively, for FH-CVE (F?=?12.47, P?<?0.001), FH-DM2 (F?=?7.62, P?=?0.006) as well as for FH-HT (F?=?7.30, P?=?0.007). CONCLUSION:: These findings indicate that a FH+ of cardiometabolic conditions and hypertension affects arterial stiffness in offspring independently of haemodynamic factors and self-reported CMD in the offspring without sex differences.
(Less)
- author
- Fatehali, Abd Al Hakim ; Gottsäter, Mikael LU and Nilsson, Peter M. LU
- organization
- publishing date
- 2017-06-28
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Hypertension
- volume
- 35
- issue
- 11
- pages
- 2262 - 2267
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- scopus:85021691949
- pmid:28661959
- wos:000411899000021
- ISSN
- 0263-6352
- DOI
- 10.1097/HJH.0000000000001457
- language
- English
- LU publication?
- yes
- id
- c7bc0fca-3fdf-434a-a940-0ed4af054873
- date added to LUP
- 2017-08-10 11:37:56
- date last changed
- 2024-05-12 18:39:12
@article{c7bc0fca-3fdf-434a-a940-0ed4af054873,
abstract = {{<p>OBJECTIVE:: Arterial stiffening increases with age and is associated with increased cardiovascular risk. Several risk factors have been shown to predict the development of arterial stiffening; however, a positive family history (FH+) of cardiometabolic disease (CMD) and hypertension has not been extensively studied. We hypothesize that FH+ of CMD plays a significant role in the development of arterial stiffening in offspring. METHODS:: We used data from the population-based Malmö Diet Cancer study (n?=?3056) examined in 1992–1996 and again in 2007–2012. Several variables were analysed, including anthropometrics, carotid–femoral pulse wave velocity and FH+. The association between FH+ of CMD and arterial stiffening in the offspring was analysed with analysis of covariance in SPSS. FH+ was subdivided into three categories: family history for cardiovascular events (FH-CVEs), family history for diabetes mellitus type 2 (FH-DM2) and family history for hypertension (FH-HT). The first analysis of covariance-model was adjusted for age, sex, mean arterial pressure and heart rate; the second model additionally adjusted for self-reported medical history in the offspring. RESULTS:: Data indicated that FH-CVE (F?=?14.64, P?<?0.001), FH-DM2 (F?=?18.57, P?<?0.001) and FH-HT (F?=?13.92, P?<?0.001) all significantly increased carotid–femoral pulse wave velocity levels. The results remained when additional adjustment was made for confounders and for self-reported CMD in the index participants, respectively, for FH-CVE (F?=?12.47, P?<?0.001), FH-DM2 (F?=?7.62, P?=?0.006) as well as for FH-HT (F?=?7.30, P?=?0.007). CONCLUSION:: These findings indicate that a FH+ of cardiometabolic conditions and hypertension affects arterial stiffness in offspring independently of haemodynamic factors and self-reported CMD in the offspring without sex differences.</p>}},
author = {{Fatehali, Abd Al Hakim and Gottsäter, Mikael and Nilsson, Peter M.}},
issn = {{0263-6352}},
language = {{eng}},
month = {{06}},
number = {{11}},
pages = {{2262--2267}},
publisher = {{Lippincott Williams & Wilkins}},
series = {{Journal of Hypertension}},
title = {{Family history of cardiometabolic diseases and its association with arterial stiffness in the Malmö Diet Cancer cohort}},
url = {{http://dx.doi.org/10.1097/HJH.0000000000001457}},
doi = {{10.1097/HJH.0000000000001457}},
volume = {{35}},
year = {{2017}},
}