Incidence and outcomes of acute mesenteric ischaemia : a systematic review and meta-analysis
Tamme, Kadri ; Reintam Blaser, Annika ; Laisaar, Kaja Triin ; Mändul, Merli ; Kals, Jaak ; Forbes, Alastair ; Kiss, Olga ; Acosta, Stefan LU
; Bjørck, Martin
and Starkopf, Joel
(2022)
In BMJ Open
12(10).
- Abstract
Objective To estimate the incidence of acute mesenteric ischaemia (AMI), proportions of its different forms and short-term and long-term mortality. Design Systematic review and meta-analysis. Data sources MEDLINE (Ovid), Web of Science, Scopus and Cochrane Library were searched until 26 July 2022. Eligibility criteria Studies reporting data on the incidence and outcomes of AMI in adult populations. Data extraction and synthesis Data extraction and quality assessment with modified Newcastle-Ottawa scale were performed using predeveloped standard forms. The outcomes were the incidence of AMI and its different forms in the general population and in patients admitted to hospital, and the mortality of AMI in its different forms. Results From... (More)
Objective To estimate the incidence of acute mesenteric ischaemia (AMI), proportions of its different forms and short-term and long-term mortality. Design Systematic review and meta-analysis. Data sources MEDLINE (Ovid), Web of Science, Scopus and Cochrane Library were searched until 26 July 2022. Eligibility criteria Studies reporting data on the incidence and outcomes of AMI in adult populations. Data extraction and synthesis Data extraction and quality assessment with modified Newcastle-Ottawa scale were performed using predeveloped standard forms. The outcomes were the incidence of AMI and its different forms in the general population and in patients admitted to hospital, and the mortality of AMI in its different forms. Results From 3064 records, 335 full texts were reviewed and 163 included in the quantitative analysis. The mean incidence of AMI was 6.2 (95% CI 1.9 to 12.9) per 100 000 person years. On average 5.0 (95% CI 3.3 to 7.1) of 10 000 hospital admissions were due to AMI. Occlusive arterial AMI was the most common form constituting 68.6% (95% CI 63.7 to 73.2) of all AMI cases, with similar proportions of embolism and thrombosis. Overall short-term mortality (in-hospital or within 30 days) of AMI was 59.6% (95% CI 55.5 to 63.6), being 68.7% (95% CI 60.8 to 74.9) in patients treated before the year 2000 and 55.0% (95% CI 45.5 to 64.1) in patients treated from 2000 onwards (p<0.05). The mid/long-term mortality of AMI was 68.2% (95% CI 60.7 to 74.9). Mortality due to mesenteric venous thrombosis was 24.6% (95% CI 17.0 to 32.9) and of non-occlusive mesenteric ischaemia 58.4% (95% CI 48.6 to 67.7). The short-term mortality of revascularised occlusive arterial AMI was 33.9% (95% CI 30.7 to 37.4). Conclusions In adult patients, AMI is a rarely diagnosed condition with high mortality, although with improvement of treatment results over the last decades. Two thirds of AMI cases are of occlusive arterial origin with potential for better survival if revascularised. PROSPERO registration number CRD42021247148.
(Less)
- author
- Tamme, Kadri
; Reintam Blaser, Annika
; Laisaar, Kaja Triin
; Mändul, Merli
; Kals, Jaak
; Forbes, Alastair
; Kiss, Olga
; Acosta, Stefan
LU
; Bjørck, Martin
and Starkopf, Joel
- organization
- publishing date
- 2022-10
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Adult intensive & critical care, VASCULAR MEDICINE, Vascular surgery
- in
- BMJ Open
- volume
- 12
- issue
- 10
- article number
- e062846
- publisher
- BMJ Publishing Group
- external identifiers
-
- pmid:36283747
- scopus:85140685837
- ISSN
- 2044-6055
- DOI
- 10.1136/bmjopen-2022-062846
- language
- English
- LU publication?
- yes
- id
- c7db88cb-8692-47f1-bcd2-683013e7e5ae
- date added to LUP
- 2022-12-13 12:07:21
- date last changed
- 2024-06-13 21:33:01
@article{c7db88cb-8692-47f1-bcd2-683013e7e5ae,
abstract = {{<p>Objective To estimate the incidence of acute mesenteric ischaemia (AMI), proportions of its different forms and short-term and long-term mortality. Design Systematic review and meta-analysis. Data sources MEDLINE (Ovid), Web of Science, Scopus and Cochrane Library were searched until 26 July 2022. Eligibility criteria Studies reporting data on the incidence and outcomes of AMI in adult populations. Data extraction and synthesis Data extraction and quality assessment with modified Newcastle-Ottawa scale were performed using predeveloped standard forms. The outcomes were the incidence of AMI and its different forms in the general population and in patients admitted to hospital, and the mortality of AMI in its different forms. Results From 3064 records, 335 full texts were reviewed and 163 included in the quantitative analysis. The mean incidence of AMI was 6.2 (95% CI 1.9 to 12.9) per 100 000 person years. On average 5.0 (95% CI 3.3 to 7.1) of 10 000 hospital admissions were due to AMI. Occlusive arterial AMI was the most common form constituting 68.6% (95% CI 63.7 to 73.2) of all AMI cases, with similar proportions of embolism and thrombosis. Overall short-term mortality (in-hospital or within 30 days) of AMI was 59.6% (95% CI 55.5 to 63.6), being 68.7% (95% CI 60.8 to 74.9) in patients treated before the year 2000 and 55.0% (95% CI 45.5 to 64.1) in patients treated from 2000 onwards (p<0.05). The mid/long-term mortality of AMI was 68.2% (95% CI 60.7 to 74.9). Mortality due to mesenteric venous thrombosis was 24.6% (95% CI 17.0 to 32.9) and of non-occlusive mesenteric ischaemia 58.4% (95% CI 48.6 to 67.7). The short-term mortality of revascularised occlusive arterial AMI was 33.9% (95% CI 30.7 to 37.4). Conclusions In adult patients, AMI is a rarely diagnosed condition with high mortality, although with improvement of treatment results over the last decades. Two thirds of AMI cases are of occlusive arterial origin with potential for better survival if revascularised. PROSPERO registration number CRD42021247148.</p>}},
author = {{Tamme, Kadri and Reintam Blaser, Annika and Laisaar, Kaja Triin and Mändul, Merli and Kals, Jaak and Forbes, Alastair and Kiss, Olga and Acosta, Stefan and Bjørck, Martin and Starkopf, Joel}},
issn = {{2044-6055}},
keywords = {{Adult intensive & critical care; VASCULAR MEDICINE; Vascular surgery}},
language = {{eng}},
number = {{10}},
publisher = {{BMJ Publishing Group}},
series = {{BMJ Open}},
title = {{Incidence and outcomes of acute mesenteric ischaemia : a systematic review and meta-analysis}},
url = {{http://dx.doi.org/10.1136/bmjopen-2022-062846}},
doi = {{10.1136/bmjopen-2022-062846}},
volume = {{12}},
year = {{2022}},
}