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Change of mammographic density predicts the risk of contralateral breast cancer--a case-control study

Sandberg, Maria E. C. LU ; Li, Jingmei; Hall, Per; Hartman, Mikael; Dos Santos Silva, Isabel; Humphreys, Keith LU and Czene, Kamila (2013) In Breast Cancer Research 15(4). p.1-9
Abstract

INTRODUCTION: Mammographic density is a strong risk factor for breast cancer, but it is unknown whether density at first breast cancer diagnosis and changes during follow-up influences risk of non-simultaneous contralateral breast cancer (CBC).

METHODS: We collected mammograms for CBC-patients (cases, N = 211) and unilateral breast cancer patients (controls, N = 211), individually matched on age and calendar period of first breast cancer diagnosis, type of adjuvant therapy and length of follow-up (mean follow-up time: 8.25 years). The odds of CBC as a function of changes of density during follow-up were investigated using conditional logistic regression, adjusting for non-dense area at diagnosis.

RESULTS: Patients who... (More)

INTRODUCTION: Mammographic density is a strong risk factor for breast cancer, but it is unknown whether density at first breast cancer diagnosis and changes during follow-up influences risk of non-simultaneous contralateral breast cancer (CBC).

METHODS: We collected mammograms for CBC-patients (cases, N = 211) and unilateral breast cancer patients (controls, N = 211), individually matched on age and calendar period of first breast cancer diagnosis, type of adjuvant therapy and length of follow-up (mean follow-up time: 8.25 years). The odds of CBC as a function of changes of density during follow-up were investigated using conditional logistic regression, adjusting for non-dense area at diagnosis.

RESULTS: Patients who experienced ≥10% absolute decrease in percent density had a 55% decreased odds of CBC (OR = 0.45 95% CI: 0.24 to 0.84) relative to patients who had little or no change in density from baseline to first follow-up mammogram (mean = 1.6 (SD = 0.6) years after diagnosis), whereas among those who experienced an absolute increase in percent density we could not detect any effect on the odds of CBC (OR = 0.83 95% CI: 0.24 to 2.87).

CONCLUSION: Decrease of mammographic density within the first two years after first diagnosis is associated with a significantly reduced risk of CBC, this potential new risk predictor can thus contribute to decision-making in follow-up strategies and treatment.

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publication status
published
keywords
Adult, Aged, Aged, 80 and over, Breast Density, Breast Neoplasms, Case-Control Studies, Female, Follow-Up Studies, Humans, Mammary Glands, Human, Mammography, Middle Aged, Odds Ratio, Registries, Risk, Sweden, Journal Article, Research Support, Non-U.S. Gov't
in
Breast Cancer Research
volume
15
issue
4
pages
1 - 9
publisher
BioMed Central
external identifiers
  • scopus:84880336085
ISSN
1465-5411
DOI
10.1186/bcr3451
language
English
LU publication?
no
id
c82be440-ba17-4149-a91a-ae96f8c7af42
date added to LUP
2017-10-16 08:57:22
date last changed
2018-11-21 21:35:18
@article{c82be440-ba17-4149-a91a-ae96f8c7af42,
  abstract     = {<p>INTRODUCTION: Mammographic density is a strong risk factor for breast cancer, but it is unknown whether density at first breast cancer diagnosis and changes during follow-up influences risk of non-simultaneous contralateral breast cancer (CBC).</p><p>METHODS: We collected mammograms for CBC-patients (cases, N = 211) and unilateral breast cancer patients (controls, N = 211), individually matched on age and calendar period of first breast cancer diagnosis, type of adjuvant therapy and length of follow-up (mean follow-up time: 8.25 years). The odds of CBC as a function of changes of density during follow-up were investigated using conditional logistic regression, adjusting for non-dense area at diagnosis.</p><p>RESULTS: Patients who experienced ≥10% absolute decrease in percent density had a 55% decreased odds of CBC (OR = 0.45 95% CI: 0.24 to 0.84) relative to patients who had little or no change in density from baseline to first follow-up mammogram (mean = 1.6 (SD = 0.6) years after diagnosis), whereas among those who experienced an absolute increase in percent density we could not detect any effect on the odds of CBC (OR = 0.83 95% CI: 0.24 to 2.87).</p><p>CONCLUSION: Decrease of mammographic density within the first two years after first diagnosis is associated with a significantly reduced risk of CBC, this potential new risk predictor can thus contribute to decision-making in follow-up strategies and treatment.</p>},
  articleno    = {R57},
  author       = {Sandberg, Maria E. C. and Li, Jingmei and Hall, Per and Hartman, Mikael and Dos Santos Silva, Isabel and Humphreys, Keith and Czene, Kamila},
  issn         = {1465-5411},
  keyword      = {Adult,Aged,Aged, 80 and over,Breast Density,Breast Neoplasms,Case-Control Studies,Female,Follow-Up Studies,Humans,Mammary Glands, Human,Mammography,Middle Aged,Odds Ratio,Registries,Risk,Sweden,Journal Article,Research Support, Non-U.S. Gov't},
  language     = {eng},
  number       = {4},
  pages        = {1--9},
  publisher    = {BioMed Central},
  series       = {Breast Cancer Research},
  title        = {Change of mammographic density predicts the risk of contralateral breast cancer--a case-control study},
  url          = {http://dx.doi.org/10.1186/bcr3451},
  volume       = {15},
  year         = {2013},
}