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Ontogenetic patterns of thyrotropin-releasing hormone-like material in rat hypothalamus, pancreas, and retina : Selective effect of light deprivation

Martino, E. ; Seo, H. ; Lernmark, A. LU orcid and Refetoff, S. (1980) In Proceedings of the National Academy of Sciences of the United States of America 77(7 II). p.4345-4348
Abstract

Recent observations have shown the presence of thyrotropin-releasing hormone-like material (TRH-LM) in rat pancreatic islets and in retina. Its immunological and biological properties are identical to those of synthetic thyrotropin-releasing hormone (thyroliberin). This communication deals with the ontogenesis of TRH-LM in rat pancreas and retina as compared to that of rat hypothalamus. Effects of sex and exposure to constant dark were also studied. Results show that asynchronous changes in the concentration of TRH-LM occur during the postnatal maturation of these tissues, presumably mediated by organ-specific control mechanisms - e.g., light affects only the accumulation of TRH-LM in the retina. TRH-LM may act as neurotransmitter in... (More)

Recent observations have shown the presence of thyrotropin-releasing hormone-like material (TRH-LM) in rat pancreatic islets and in retina. Its immunological and biological properties are identical to those of synthetic thyrotropin-releasing hormone (thyroliberin). This communication deals with the ontogenesis of TRH-LM in rat pancreas and retina as compared to that of rat hypothalamus. Effects of sex and exposure to constant dark were also studied. Results show that asynchronous changes in the concentration of TRH-LM occur during the postnatal maturation of these tissues, presumably mediated by organ-specific control mechanisms - e.g., light affects only the accumulation of TRH-LM in the retina. TRH-LM may act as neurotransmitter in the regulation of pancreatic islet cell function and in the development of photoreception in the retina. Increases in hypothalamic TRH-LM seem to parallel the development of the pituitary-thyroid secretory activity, but the function of extrahypothalamic TRH-LM remains speculative.

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author
; ; and
publishing date
type
Contribution to journal
publication status
published
in
Proceedings of the National Academy of Sciences of the United States of America
volume
77
issue
7 II
pages
4345 - 4348
publisher
National Academy of Sciences
external identifiers
  • scopus:3643071406
  • pmid:6776526
ISSN
0027-8424
DOI
10.1073/pnas.77.7.4345
language
English
LU publication?
no
id
c832e2a2-9784-4971-820a-6e952d611bbf
date added to LUP
2019-09-16 15:36:52
date last changed
2025-01-24 02:39:45
@article{c832e2a2-9784-4971-820a-6e952d611bbf,
  abstract     = {{<p>Recent observations have shown the presence of thyrotropin-releasing hormone-like material (TRH-LM) in rat pancreatic islets and in retina. Its immunological and biological properties are identical to those of synthetic thyrotropin-releasing hormone (thyroliberin). This communication deals with the ontogenesis of TRH-LM in rat pancreas and retina as compared to that of rat hypothalamus. Effects of sex and exposure to constant dark were also studied. Results show that asynchronous changes in the concentration of TRH-LM occur during the postnatal maturation of these tissues, presumably mediated by organ-specific control mechanisms - e.g., light affects only the accumulation of TRH-LM in the retina. TRH-LM may act as neurotransmitter in the regulation of pancreatic islet cell function and in the development of photoreception in the retina. Increases in hypothalamic TRH-LM seem to parallel the development of the pituitary-thyroid secretory activity, but the function of extrahypothalamic TRH-LM remains speculative.</p>}},
  author       = {{Martino, E. and Seo, H. and Lernmark, A. and Refetoff, S.}},
  issn         = {{0027-8424}},
  language     = {{eng}},
  month        = {{12}},
  number       = {{7 II}},
  pages        = {{4345--4348}},
  publisher    = {{National Academy of Sciences}},
  series       = {{Proceedings of the National Academy of Sciences of the United States of America}},
  title        = {{Ontogenetic patterns of thyrotropin-releasing hormone-like material in rat hypothalamus, pancreas, and retina : Selective effect of light deprivation}},
  url          = {{http://dx.doi.org/10.1073/pnas.77.7.4345}},
  doi          = {{10.1073/pnas.77.7.4345}},
  volume       = {{77}},
  year         = {{1980}},
}