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Uptake of nanowires by human lung adenocarcinoma cells

Abariute, Laura LU ; Lard, Mercy LU ; Hebisch, Elke LU and Prinz, Christelle N. LU (2019) In PLoS ONE 14(6).
Abstract

Semiconductor nanowires are increasingly used in optoelectronic devices. However, their effects on human health have not been assessed fully. Here, we investigate the effects of gallium phosphide nanowires on human lung adenocarcinoma cells. Four different geometries of nanowires were suspended in the cell culture for 48 hours. We show that cells internalize the nanowires and that the nanowires have no effect on cell proliferation rate, motility, viability and intracellular ROS levels. By blocking specific internalization pathways, we demonstrate that the nanowire uptake is the result of a combination of processes, requiring dynamin and actin polymerization, which suggests an internalization through macropinocytosis and phagocytosis.

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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
PLoS ONE
volume
14
issue
6
article number
e0218122
publisher
Public Library of Science
external identifiers
  • pmid:31226121
  • scopus:85067605289
ISSN
1932-6203
DOI
10.1371/journal.pone.0218122
language
English
LU publication?
yes
id
c88cd6f5-ad90-4f80-a818-a94840087a75
date added to LUP
2019-07-05 11:04:12
date last changed
2020-10-20 02:05:41
@article{c88cd6f5-ad90-4f80-a818-a94840087a75,
  abstract     = {<p>Semiconductor nanowires are increasingly used in optoelectronic devices. However, their effects on human health have not been assessed fully. Here, we investigate the effects of gallium phosphide nanowires on human lung adenocarcinoma cells. Four different geometries of nanowires were suspended in the cell culture for 48 hours. We show that cells internalize the nanowires and that the nanowires have no effect on cell proliferation rate, motility, viability and intracellular ROS levels. By blocking specific internalization pathways, we demonstrate that the nanowire uptake is the result of a combination of processes, requiring dynamin and actin polymerization, which suggests an internalization through macropinocytosis and phagocytosis.</p>},
  author       = {Abariute, Laura and Lard, Mercy and Hebisch, Elke and Prinz, Christelle N.},
  issn         = {1932-6203},
  language     = {eng},
  number       = {6},
  publisher    = {Public Library of Science},
  series       = {PLoS ONE},
  title        = {Uptake of nanowires by human lung adenocarcinoma cells},
  url          = {http://dx.doi.org/10.1371/journal.pone.0218122},
  doi          = {10.1371/journal.pone.0218122},
  volume       = {14},
  year         = {2019},
}