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High concentration of immunoglobulin A is associated with temporal lobe epilepsy

Liimatainen, Suvi ; Fallah, Mahdi LU ; Kharazmi, Elham LU ; Haapala, Anna Maija ; Isojärvi, Jouko and Peltola, Jukka (2013) In Epilepsy Research 103(1). p.54-61
Abstract

Introduction: Dysfunction of immunoglobulins (Igs) has been detected in association with antiepileptic drugs (AEDs) and in newly diagnosed epilepsy patients. The aim of this study was to evaluate the effect of clinical features and the current or past use of AEDs on serum Ig concentrations in a well-examined group of patients with refractory epilepsy. Patients and methods: Using a nephelometric method, concentrations of IgA, IgG and IgM were analyzed in the sera of 257 patients with refractory epilepsy, 15 patients with controlled epilepsy and 584 healthy control subjects. Results: A low IgA concentration was found in 8.8% of the patients with epilepsy compared with 1.9% of the control subjects. High concentrations of IgA were... (More)

Introduction: Dysfunction of immunoglobulins (Igs) has been detected in association with antiepileptic drugs (AEDs) and in newly diagnosed epilepsy patients. The aim of this study was to evaluate the effect of clinical features and the current or past use of AEDs on serum Ig concentrations in a well-examined group of patients with refractory epilepsy. Patients and methods: Using a nephelometric method, concentrations of IgA, IgG and IgM were analyzed in the sera of 257 patients with refractory epilepsy, 15 patients with controlled epilepsy and 584 healthy control subjects. Results: A low IgA concentration was found in 8.8% of the patients with epilepsy compared with 1.9% of the control subjects. High concentrations of IgA were associated with temporal lobe epilepsy (TLE) compared with other epilepsy types (p= 0.042). The high concentrations of IgA (p= 0.042), low concentrations of IgG (p= 0.002), and high concentrations of IgG (p= 0.008) were also associated with autoimmune diseases. The use of lamotrigine, nitrazepam, oxcarbazepine, topiramate and valproic acid was associated with alterations in Ig concentrations. Current use of topiramate was associated with high serum IgG and IgM concentrations (OR 10.39; 95% CI: 3.08-35.04 and OR 7.02; 95% CI: 1.25-39.55, respectively). Discussion: The finding of high serum IgA concentration in patients with TLE strengthens the previously found association of immunological activity in the epileptic temporal lobe rather than other brain regions. The newly observed immunological effects of topiramate are important to proper AED choice in patients with refractory epilepsy.

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author
; ; ; ; and
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Immunoglobulin, Immunology, Refractory epilepsy, Temporal lobe epilepsy, Topiramate
in
Epilepsy Research
volume
103
issue
1
pages
54 - 61
publisher
Elsevier
external identifiers
  • pmid:22749917
  • scopus:84872132610
ISSN
0920-1211
DOI
10.1016/j.eplepsyres.2012.06.002
language
English
LU publication?
no
additional info
Funding Information: The study is supported by the grant from the Medical Research Fund of Tampere University Hospital , Finland.
id
c8940d79-dfb5-415a-b1fc-e392a877d00d
date added to LUP
2021-12-16 01:24:06
date last changed
2024-01-05 22:57:36
@article{c8940d79-dfb5-415a-b1fc-e392a877d00d,
  abstract     = {{<p>Introduction: Dysfunction of immunoglobulins (Igs) has been detected in association with antiepileptic drugs (AEDs) and in newly diagnosed epilepsy patients. The aim of this study was to evaluate the effect of clinical features and the current or past use of AEDs on serum Ig concentrations in a well-examined group of patients with refractory epilepsy. Patients and methods: Using a nephelometric method, concentrations of IgA, IgG and IgM were analyzed in the sera of 257 patients with refractory epilepsy, 15 patients with controlled epilepsy and 584 healthy control subjects. Results: A low IgA concentration was found in 8.8% of the patients with epilepsy compared with 1.9% of the control subjects. High concentrations of IgA were associated with temporal lobe epilepsy (TLE) compared with other epilepsy types (p= 0.042). The high concentrations of IgA (p= 0.042), low concentrations of IgG (p= 0.002), and high concentrations of IgG (p= 0.008) were also associated with autoimmune diseases. The use of lamotrigine, nitrazepam, oxcarbazepine, topiramate and valproic acid was associated with alterations in Ig concentrations. Current use of topiramate was associated with high serum IgG and IgM concentrations (OR 10.39; 95% CI: 3.08-35.04 and OR 7.02; 95% CI: 1.25-39.55, respectively). Discussion: The finding of high serum IgA concentration in patients with TLE strengthens the previously found association of immunological activity in the epileptic temporal lobe rather than other brain regions. The newly observed immunological effects of topiramate are important to proper AED choice in patients with refractory epilepsy.</p>}},
  author       = {{Liimatainen, Suvi and Fallah, Mahdi and Kharazmi, Elham and Haapala, Anna Maija and Isojärvi, Jouko and Peltola, Jukka}},
  issn         = {{0920-1211}},
  keywords     = {{Immunoglobulin; Immunology; Refractory epilepsy; Temporal lobe epilepsy; Topiramate}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{54--61}},
  publisher    = {{Elsevier}},
  series       = {{Epilepsy Research}},
  title        = {{High concentration of immunoglobulin A is associated with temporal lobe epilepsy}},
  url          = {{http://dx.doi.org/10.1016/j.eplepsyres.2012.06.002}},
  doi          = {{10.1016/j.eplepsyres.2012.06.002}},
  volume       = {{103}},
  year         = {{2013}},
}