Ischemia-induced upregulation of excitatory amino acid transport sites
(1993) In Brain Research 622(1-2). p.93-98- Abstract
The response of excitatory amino acid transporter binding sites in the rat brain to 10 min of cerebral ischemia induced by bilateral common carotid occlusion combined with hypotension was examined. We observed a transient increase in the density of transporter binding sites that was first noticeable at 5 min post-recovery and persisted for 48 h. The increase in binding sites was found throughout the brain, but was most prevalent in hippocampus and other cortical regions. We conclude that delayed neuronal death following transient cerebral ischemia may not be due to a decrease in the number of excitatory amino acid transport sites.
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https://lup.lub.lu.se/record/c8ae3b8d-47fb-49d4-9e45-60d27de43c3a
- author
- Anderson, Kevin J. ; Nellgård, Bengt LU and Wieloch, Tadeusz LU
- organization
- publishing date
- 1993-09-17
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Aspartate, Excitotoxicity, Glutamate, Ischemia, Neuronal death, Transport
- in
- Brain Research
- volume
- 622
- issue
- 1-2
- pages
- 93 - 98
- publisher
- Elsevier
- external identifiers
-
- pmid:7902192
- scopus:0027216706
- ISSN
- 0006-8993
- DOI
- 10.1016/0006-8993(93)90806-X
- language
- English
- LU publication?
- yes
- id
- c8ae3b8d-47fb-49d4-9e45-60d27de43c3a
- date added to LUP
- 2019-06-13 16:20:00
- date last changed
- 2024-01-01 10:16:53
@article{c8ae3b8d-47fb-49d4-9e45-60d27de43c3a, abstract = {{<p>The response of excitatory amino acid transporter binding sites in the rat brain to 10 min of cerebral ischemia induced by bilateral common carotid occlusion combined with hypotension was examined. We observed a transient increase in the density of transporter binding sites that was first noticeable at 5 min post-recovery and persisted for 48 h. The increase in binding sites was found throughout the brain, but was most prevalent in hippocampus and other cortical regions. We conclude that delayed neuronal death following transient cerebral ischemia may not be due to a decrease in the number of excitatory amino acid transport sites.</p>}}, author = {{Anderson, Kevin J. and Nellgård, Bengt and Wieloch, Tadeusz}}, issn = {{0006-8993}}, keywords = {{Aspartate; Excitotoxicity; Glutamate; Ischemia; Neuronal death; Transport}}, language = {{eng}}, month = {{09}}, number = {{1-2}}, pages = {{93--98}}, publisher = {{Elsevier}}, series = {{Brain Research}}, title = {{Ischemia-induced upregulation of excitatory amino acid transport sites}}, url = {{http://dx.doi.org/10.1016/0006-8993(93)90806-X}}, doi = {{10.1016/0006-8993(93)90806-X}}, volume = {{622}}, year = {{1993}}, }