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Ischemia-induced upregulation of excitatory amino acid transport sites

Anderson, Kevin J. ; Nellgård, Bengt LU and Wieloch, Tadeusz LU (1993) In Brain Research 622(1-2). p.93-98
Abstract

The response of excitatory amino acid transporter binding sites in the rat brain to 10 min of cerebral ischemia induced by bilateral common carotid occlusion combined with hypotension was examined. We observed a transient increase in the density of transporter binding sites that was first noticeable at 5 min post-recovery and persisted for 48 h. The increase in binding sites was found throughout the brain, but was most prevalent in hippocampus and other cortical regions. We conclude that delayed neuronal death following transient cerebral ischemia may not be due to a decrease in the number of excitatory amino acid transport sites.

Please use this url to cite or link to this publication:
author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Aspartate, Excitotoxicity, Glutamate, Ischemia, Neuronal death, Transport
in
Brain Research
volume
622
issue
1-2
pages
93 - 98
publisher
Elsevier
external identifiers
  • scopus:0027216706
  • pmid:7902192
ISSN
0006-8993
DOI
10.1016/0006-8993(93)90806-X
language
English
LU publication?
yes
id
c8ae3b8d-47fb-49d4-9e45-60d27de43c3a
date added to LUP
2019-06-13 16:20:00
date last changed
2024-01-01 10:16:53
@article{c8ae3b8d-47fb-49d4-9e45-60d27de43c3a,
  abstract     = {{<p>The response of excitatory amino acid transporter binding sites in the rat brain to 10 min of cerebral ischemia induced by bilateral common carotid occlusion combined with hypotension was examined. We observed a transient increase in the density of transporter binding sites that was first noticeable at 5 min post-recovery and persisted for 48 h. The increase in binding sites was found throughout the brain, but was most prevalent in hippocampus and other cortical regions. We conclude that delayed neuronal death following transient cerebral ischemia may not be due to a decrease in the number of excitatory amino acid transport sites.</p>}},
  author       = {{Anderson, Kevin J. and Nellgård, Bengt and Wieloch, Tadeusz}},
  issn         = {{0006-8993}},
  keywords     = {{Aspartate; Excitotoxicity; Glutamate; Ischemia; Neuronal death; Transport}},
  language     = {{eng}},
  month        = {{09}},
  number       = {{1-2}},
  pages        = {{93--98}},
  publisher    = {{Elsevier}},
  series       = {{Brain Research}},
  title        = {{Ischemia-induced upregulation of excitatory amino acid transport sites}},
  url          = {{http://dx.doi.org/10.1016/0006-8993(93)90806-X}},
  doi          = {{10.1016/0006-8993(93)90806-X}},
  volume       = {{622}},
  year         = {{1993}},
}