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Ferritin nanocages loaded with gold ions induce oxidative stress and apoptosis in MCF-7 human breast cancer cells

Monti, Daria Maria ; Ferraro, Giarita ; Petruk, Ganna LU orcid ; Maiore, Laura ; Pane, Francesca ; Amoresano, Angela ; Cinellu, Maria Agostina and Merlino, Antonello (2017) In Dalton Transactions 46(44). p.15354-15362
Abstract

Two anticancer gold(iii) compounds, Au2phen and Auoxo4, were encapsulated within a ferritin nanocage. The gold-compound loaded proteins were characterized by UV-Vis spectroscopy, inductively coupled plasma mass spectrometry and circular dichroism. X-ray crystallography shows that the compounds degrade upon encapsulation and gold(i) ions bind Ft within the cage, close to the side chains of Cys126. The gold-encapsulated nanocarriers are cytotoxic to human cancer cells. Au(i)-loaded Ft, obtained upon the encapsulation of Au2phen within the cage, induces oxidative stress activation, which finally leads to apoptosis in MCF-7 cells.

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author
; ; ; ; ; ; and
publishing date
type
Contribution to journal
publication status
published
in
Dalton Transactions
volume
46
issue
44
pages
15354 - 15362
publisher
Royal Society of Chemistry
external identifiers
  • pmid:29072740
  • scopus:85034075066
ISSN
1477-9226
DOI
10.1039/c7dt02370g
language
English
LU publication?
no
additional info
Publisher Copyright: © 2017 The Royal Society of Chemistry.
id
c8b5d01b-8956-4b2b-a59d-2b56a2c7389f
date added to LUP
2025-01-21 15:43:08
date last changed
2025-04-29 22:47:05
@article{c8b5d01b-8956-4b2b-a59d-2b56a2c7389f,
  abstract     = {{<p>Two anticancer gold(iii) compounds, Au<sub>2</sub>phen and Auoxo4, were encapsulated within a ferritin nanocage. The gold-compound loaded proteins were characterized by UV-Vis spectroscopy, inductively coupled plasma mass spectrometry and circular dichroism. X-ray crystallography shows that the compounds degrade upon encapsulation and gold(i) ions bind Ft within the cage, close to the side chains of Cys126. The gold-encapsulated nanocarriers are cytotoxic to human cancer cells. Au(i)-loaded Ft, obtained upon the encapsulation of Au<sub>2</sub>phen within the cage, induces oxidative stress activation, which finally leads to apoptosis in MCF-7 cells.</p>}},
  author       = {{Monti, Daria Maria and Ferraro, Giarita and Petruk, Ganna and Maiore, Laura and Pane, Francesca and Amoresano, Angela and Cinellu, Maria Agostina and Merlino, Antonello}},
  issn         = {{1477-9226}},
  language     = {{eng}},
  number       = {{44}},
  pages        = {{15354--15362}},
  publisher    = {{Royal Society of Chemistry}},
  series       = {{Dalton Transactions}},
  title        = {{Ferritin nanocages loaded with gold ions induce oxidative stress and apoptosis in MCF-7 human breast cancer cells}},
  url          = {{http://dx.doi.org/10.1039/c7dt02370g}},
  doi          = {{10.1039/c7dt02370g}},
  volume       = {{46}},
  year         = {{2017}},
}