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The hijackers guide to escaping complement : Lessons learned from pathogens

Ermert, D. LU ; Ram, Sanjay and Laabei, Maisem LU (2019) In MOLECULAR IMMUNOLOGY 114. p.49-61
Abstract

Pathogens that invade the human host are confronted by a multitude of defence mechanisms aimed at preventing colonization, dissemination and proliferation. The most frequent outcome of this interaction is microbial elimination, in which the complement system plays a major role. Complement, an essential feature of the innate immune machinery, rapidly identifies and marks pathogens for efficient removal. Consequently, this creates a selective pressure for microbes to evolve strategies to combat complement, permitting host colonization and access to resources. All successful pathogens have developed mechanisms to resist complement activity which are intimately aligned with their capacity to cause disease. In this review, we describe the... (More)

Pathogens that invade the human host are confronted by a multitude of defence mechanisms aimed at preventing colonization, dissemination and proliferation. The most frequent outcome of this interaction is microbial elimination, in which the complement system plays a major role. Complement, an essential feature of the innate immune machinery, rapidly identifies and marks pathogens for efficient removal. Consequently, this creates a selective pressure for microbes to evolve strategies to combat complement, permitting host colonization and access to resources. All successful pathogens have developed mechanisms to resist complement activity which are intimately aligned with their capacity to cause disease. In this review, we describe the successful methods various pathogens use to evade complement activation, shut down inflammatory signalling through complement, circumvent opsonisation and override terminal pathway lysis. This review summarizes how pathogens undermine innate immunity: ‘The Hijackers Guide to Complement’.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
bacteria, Complement System, immune evasion, pathogens
in
MOLECULAR IMMUNOLOGY
volume
114
pages
13 pages
publisher
Pergamon
external identifiers
  • scopus:85069599321
ISSN
0161-5890
DOI
10.1016/j.molimm.2019.07.018
language
English
LU publication?
yes
id
c8b960e3-2dab-4f9c-a454-7583739ec73b
date added to LUP
2019-08-02 13:03:31
date last changed
2019-08-28 04:57:36
@article{c8b960e3-2dab-4f9c-a454-7583739ec73b,
  abstract     = {<p>Pathogens that invade the human host are confronted by a multitude of defence mechanisms aimed at preventing colonization, dissemination and proliferation. The most frequent outcome of this interaction is microbial elimination, in which the complement system plays a major role. Complement, an essential feature of the innate immune machinery, rapidly identifies and marks pathogens for efficient removal. Consequently, this creates a selective pressure for microbes to evolve strategies to combat complement, permitting host colonization and access to resources. All successful pathogens have developed mechanisms to resist complement activity which are intimately aligned with their capacity to cause disease. In this review, we describe the successful methods various pathogens use to evade complement activation, shut down inflammatory signalling through complement, circumvent opsonisation and override terminal pathway lysis. This review summarizes how pathogens undermine innate immunity: ‘The Hijackers Guide to Complement’.</p>},
  author       = {Ermert, D. and Ram, Sanjay and Laabei, Maisem},
  issn         = {0161-5890},
  keyword      = {bacteria,Complement System,immune evasion,pathogens},
  language     = {eng},
  pages        = {49--61},
  publisher    = {Pergamon},
  series       = {MOLECULAR IMMUNOLOGY},
  title        = {The hijackers guide to escaping complement : Lessons learned from pathogens},
  url          = {http://dx.doi.org/10.1016/j.molimm.2019.07.018},
  volume       = {114},
  year         = {2019},
}